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cardiomyopathy PhD Projects, Programs & Scholarships

We have 10 cardiomyopathy PhD Projects, Programs & Scholarships

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We have 10 cardiomyopathy PhD Projects, Programs & Scholarships

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Elucidating the role of disease modifying gene variants in inherited cardiomyopathies using induced pluripotent stem cell derived cardiomyocytes and CRISPR/Cas-9.

Our group is interested in uncovering and understanding key mechanisms of disease that affect cardiac muscle function. We have a particular interest in understanding how regulation of cardiac muscle contraction is altered in common acquired and inherited cardiovascular diseases. Read more

Unravelling drug-gene-phenotype interactions in complex cardiovascular diseases (iCASE)

Globally, cardiovascular disease is the leading cause of death, with underlying genetic mutations, comorbidities and drug-induced off-target cardiotoxicity being especially troublesome. Read more

Unravelling drug-gene-phenotype interactions in complex cardiovascular diseases: A PhD studentship co-sponsored iCASE with AstraZeneca (AZ) & GlaxoSmithKline (GSK)

PhD Studentship in Stem Cell Biology, Disease Modelling and Drug Development. Joint between academia and industry. Supervisors. Chris Denning, Mattea Finelli (University of Nottingham), Davor Pavlovic (University of Birmingham), Amy Pointon (AstraZeneca), Will Stebbeds (GlaxoSmithKline). Read more

Understanding the role of alpha-actinin in cardiac disease: from molecules to in vivo models

In the heart and skeletal muscle, the Z-disc is a crucial structure to anchor thin filaments of the contractile units. Moreover, the Z-disc is recognised as a signalling hub, sensing and responding to changes in the environment. Read more

Cellular protein quality control in diabetes-associated heart disease: The insight into mechanisms and therapeutic potentials

Cardiovascular complications are the leading causes of diabetes mortality. With the exception of vascular and valvular injuries, diabetic cardiomyopathy (DCM) is a distinct myocardial disease, which is characterised by abnormal cellular metabolism and defects in organelles function, leading to impaired cardiac function. Read more

Epigenetic regulation in heart failure and cardiac sudden death

A large proportion of heart failure patients die from cardiac sudden death (SCD), a direct result of lethal ventricular arrhythmias, which is the principal cause of mortality from heart disease worldwide and remains a major unresolved public health problem. Read more

PMCA1 – a potential target for the treatment of heart failure

Our research group is focused on understanding the molecular mechanisms underlying the development and progression of heart failure and in doing so identifying potential new targets for its treatment. Read more
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