Background. Stem cells have an essential role in homeostasis, repair, and regeneration of a tissue or organ. The adult skin is home to largest collection of multipotent stem cells, which are immature cells with unlimited ability to self-renew and capacity to differentiate into different skin cell lineages. Read more
Background. Approximately 0.4% of adult human cells undergo regulated cell death (RCD) daily, primarily through apoptosis. To prevent excessive inflammation, these dead cells must be cleared in an immunologically silent manner—a process known as efferocytosis. Read more
Background. For neurodegenerative diseases such as Parkinson’s disease, where a specific cell type is lost, it is possible to consider replacing these cells to restore the lost function. Read more
Mesenchymal stem cells (MSCs) are responsible for the repair of damaged tissue following injury and disease as well as moderating innate and adaptive immune responses and regulation of self-tolerance and tissue homeostasis. Read more
Whether a cell dies or not has profound consequences on health and disease. In healthy tissue, cells that acquire high levels of genetic damage are safely removed via a process of programmed cell death. Read more
Single-cell multiomics technologies enable the profiling of different components of transcriptional machinery at single-cell resolution, such as paired RNA and chromatin accessibility. Read more
We are seeking PhD candidates who are passionate about exploring scientific questions at the intersection of physics, biology, and data science to join our new research team in “Physics of Life” at the School of Mathematical and Physical Sciences, University of Sheffield. Read more
iCASE Project - MRC’s iCASE awards provide students with experience of collaborative research with a non-academic partner, enabling the student to spend a period of time with the partner (usually no less than three months over the lifetime of the PhD). Read more
About the Project. Additional supervisor - Prof. Raj Kalaria (Newcastle University). Background. Dementia, affecting nearly 1 million people in the UK, leads to progressive cognitive decline and impairment in daily activites. Read more
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