A 2025 Crick PhD project with Aleksey Chudnovskiy. Cancer treatment has advanced with the introduction of checkpoint inhibitor drugs, which enhance the body's immune response to tumours. Read more
Background. HIV-1 remains a major global health challenge, infecting over 88 million people and causing more than 42 million deaths since its discovery. Read more
One potential approach to eliminating HTLV-1 infected cells is based on the evidence that retroviral infection can cause cellular metabolic dysregulation. Read more
A 2025 Crick PhD project with Dinis Calado. A major interest of the Immunity and Cancer Lab is to understand how healthy cells become cancerous. Read more
A 2025 Crick PhD project with Robin Lovell-Badge. Organs are made through the correct differentiation and spatial organisation of progenitor cells, where the latter can be anything from self-renewing stem cells through to committed intermediate cell types. Read more
Mesenchymal stem cells (MSCs) are responsible for the repair of damaged tissue following injury and disease as well as moderating innate and adaptive immune responses and regulation of self-tolerance and tissue homeostasis. Read more
Immunological memory of antibody responses is critical for the ability of the host to cope with secondary infections and is the basis for the development of most current vaccines. Read more
TGF-beta is a mammalian cytokine which has a large range of effects on different cells in the body. it is involved in development, immunosuppression, cancer progression and fibrosis, amongst many other pathways. Read more
A 2025 Crick-Imperial Joint PhD project with Andreas Wack (Crick) and Leticia Monin Aldama (Imperial). Please note. candidates will need to be eligible for home tuition fees to apply for this position. Read more
Project Background. Intra-tumour heterogeneity (both genetic and transcriptomic) poses one of the biggest challenges in the treatment of cancer treatment. Read more
Background & preliminary data. Dengue virus (DENV) co-circulates as four serotypes (DENV1-4) and causes symptoms ranging from uncomplicated febrile illness to lifethreatening severe dengue (SD) characterized by plasma leakage, haemorrhage and hypovolemic shock. Read more
Cancers of B cells and plasma cells, lymphomas and multiple myeloma, can be very aggressive, and often the cancer rapidly reoccurs after standard therapy. Read more
Neuroblastoma (NB) is the most common extracranial solid tumor in infants, arising from the oncogenic transformation of trunk neural crest (NC) cells—multipotent embryonic cells that develop into the adrenal gland and sympathetic neurons. Read more
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