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enzyme PhD Projects, Programmes & Scholarships for Self-funded Students

We have 69 enzyme PhD Projects, Programmes & Scholarships for Self-funded Students

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Enzyme Cascades controlled in the Electrochemical Leaf for Discovery in Antimicrobial Strategy

The University of Manchester Department of Chemistry
Antibiotic discovery is usually aimed at single entities, for example a bacterial enzyme or efflux protein. This also means that antimicrobial resistance (AMR) mechanisms are considered in terms of the individual response, for example, mutations in a single target enzyme, affording resistance to the drug. Read more
 Supervisor: Dr C Megarity
 30 April 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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New Methods for modelling cofactor-dependent enzyme structure and function

The University of Manchester Department of Chemistry
Enzymes are Nature’s catalysts and many used cofactors and/or coenzymes to catalyse their reactions. While AI and homology methods now often allow the useful prediction of protein structure from amino acid sequence, this can be more challenging when the protein/enzyme contain cofactors. Read more
 Supervisor: Prof S Hay
 27 October 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Development of chemical tools and bioactive compounds to explore the importance of enzyme activity in cancer diseases

University of Bradford Faculty of Life Sciences
Diversity-oriented synthesis (DOS) is a modern chemical methodology, which aims to synthesise small molecules that cover new chemical space with the possibility of finding unexplored biological targets or pathways that may be important for disease progression. Read more
 Supervisors: Prof K Pors, Dr V Vangala
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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PBPK modelling of disease-drug interactions using transporter and enzyme biomarker data

The University of Manchester Faculty of Biology, Medicine and Health
Precision dosing strategies require accounting for between-patient variability in pharmacokinetics. Read more
 Supervisors: Dr A Galetin, Dr Daniel Scotcher, Prof A Rostami
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Development of molecularly imprinted polymers (MIPs) assisted analytical methods for detection and monitoring of protein/enzyme biomarkers

Kingston University Faculty of Health, Science, Social Care and Education
Biomarkers have been used prolifically in the field of medicine to provide a rapid and easy method of monitoring many normal biochemical pathways and many pathological conditions without the need for any invasive procedures [1,2]. . Read more
 Supervisor: Prof J Barker
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Wearable Sample Collection for Biosensing

University of Birmingham School of Chemistry
Measurement of low abundance proteins is key for enabling early detection of diseases [1]. A widely used method for the measurement of low abundance proteins is enzyme-linked immunosorbent assay (ELISA) [2]. Read more
 Supervisor: Dr R Gupta
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Sustainable Commodity Chemicals through Enzyme Engineering & Design (SuCCEED) - 4 posts available

The University of Manchester Department of Chemistry
SuCCEED is a BBSRC-funded Prosperity Partnership multi-million project between The University of Manchester and Shell. Commodity chemicals are produced on a global scale and normally derived from finite geological sources. Read more
 Supervisors: Dr N Dixon, Dr J Esteban Serrano, Prof A Green, Prof D Leys, Dr V Spallina, Prof M Turner, Dr J Winterburn
 30 June 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Structure and function of enzyme complexes involved in post-transcriptional gene regulation

University of Nottingham School of Pharmacy
Many proteins in human cells function as part of high molecular weight multi-subunit assemblies. The structure and function of such large molecular machines is often difficult to characterise due to their complexity, low abundance and structural dynamics. Read more
 Supervisor: Dr G S Winkler
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Enzyme-responsive peptide hydrogels as in situ forming long-acting drug delivery implants

Queen’s University Belfast School of Pharmacy
One of the key issues in the treatment and prevention of disease is that patients struggle to adhere to the complex dosage regimens of therapies, which often require multiple dosing at very specific times each day. Read more
 Supervisor: Dr G Laverty
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the Roles for deSUMOylation Enzyme SENP3 in Autophagy Impaired by α-synuclein

University of Sheffield School of Biosciences
Aggregation of α-synuclein protein in neuronal cells has been strongly implicated in the pathogenesis of neurodegenerative disorders (Synucleinopathies) including Parkinson's disease and dementia with Lewy bodies. Read more
 Supervisor: Dr C Guo
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Revealing Reactivity in Cancer-Associated Heme Proteins: Novel Time-Resolved Structural Approaches

University of Leicester Molecular and Cell Biology
Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme involved in the degradation of tryptophan to kynurenine. Cancer cells upregulate IDO1 to escape normal immune responses and, in many cases, a high expression of IDO1 is connected to poor prognosis. Read more
 Supervisors: Dr HK Kwon, Dr P A Ash
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Design and Evolution of Enzymes with New Catalytic Functions

The University of Manchester Department of Chemistry
A fully funded studentship is available, based at the Manchester Institute of Biotechnology under the supervision of Prof Anthony Green. Read more
 Supervisor: Prof A Green
 31 May 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Building Enzymes with New Catalytic Functions & Design and Evolution of Enzymes with New Catalytic Functions

The University of Manchester Department of Chemistry
A fully funded studentship is available, based at the Manchester Institute of Biotechnology under the supervision of Prof Anthony Green. Read more
 Supervisor: Prof A Green
 31 May 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Clinical Gastroenterology: The regulation of GDH expression in Clostridioides difficile

University of Leeds Faculty of Medicine and Health
Clostridioides difficile infection (CDI), the most common cause of infective antibiotic-associated diarrhea in the western world, is diagnosed by a combination of tests that firstly detect the organism, then the toxins that it produces (Planche 2013). Read more
 Supervisors: Prof M Wilcox, Dr K Davies, Dr A Buckley
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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(MRC DTP CASE) Prediction of substrate binding geometry and strength in promiscuous enzymes: computational chemistry applicable to the design of pharmaceuticals and agrochemicals

The University of Manchester Faculty of Biology, Medicine and Health
We are often taught about the power of enzymes to select particular substrates from the biological milieu and of their ability to perform highly selective reactions on those substrates. Read more
 Supervisors: Dr A Leach, Dr S De Visser, Dr C Trujillo
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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