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We have 18 epilepsy PhD Projects, Programmes & Scholarships for Self-funded Students

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epilepsy PhD Projects, Programmes & Scholarships for Self-funded Students

We have 18 epilepsy PhD Projects, Programmes & Scholarships for Self-funded Students

Epilepsy and the ageing brain

Our ability to remember ‘where I put my car keys today’ instead of ‘where I put them yesterday’ depends on a computational process called pattern separation. Read more

Using microRNA inhibitors to boost GABAergic inhibition as a genetic therapy for epilepsy

Epilepsy is a chronic neurological disease characterised by recurrent spontaneous seizures and cognitive co-morbidities. Current small molecule approaches to treating epilepsy are ineffective in a significant portion of cases, and are associated with substantial adverse effects. Read more

The breakdown of neurovascular coupling in the diseased state specifically Epilepsy and Alzheimer’s disease

Epilepsy is the most common neurological condition in the UK, affecting 1 – 2 % of the population. Epilepsies often involve only a small area of the brain - the epileptic focus – and the abnormal activity can propagate out from there. Read more

Investigation into the antiepileptic efficacy and mechanism of combination vitamin D and Ganoderma Lucidum polysaccharides

Epilepsy, caused by abnormal firing of neurons in the brain, affects 50 million people globally [1]. Almost one-third of epileptic patients do not respond well to antiepileptic drugs, and their side effects are associated with cognitive impairment, psychiatric problems, and recurrent epileptic adverse reactions [2, 3]. Read more

Vascularising human mini-brains in a dish

Blood vessels play a pivotal role in brain development and function. They promote tissue growth and survival by supplying nutrients and oxygen to surrounding tissues, signals to progenitor populations, as well as guiding neuronal migration. Read more

In silico modelling of endocannabinoid evolution

In the brain, the endocannabinoid (eCB) system maintains adequate neurotransmission (Lu and Mackie 2016). Indeed, the eCB system provides a negative feedback mechanism, preventing over-activation of synaptic transmission. Read more

Self funded MSc by Research or PhD in Biology: Ion channel signalling in cancer cells

Lead supervisor: Dr W Brackenbury. The student will be registered with the Department of Biology. Our cells constantly sense and transport ions present in their environment. Read more

Developing a clinical pathway to support nurse led whole genome sequencing for neurological diseases

In this project we will develop pathways to enable specialist nurses to request whole genome sequencing (WGS) for adult neurology patients throughout the NHS; improving the efficiency of the process, freeing consultant neurologist time and improving equity of access. Read more

Understanding how mutations in the kinase TLK2 cause a neurodevelopmental disorder

Tousled-like kinase 2 (TLK2) was recently identified as a novel genetic locus for a neurodevelopmental disorder. Patients predominantly possess de novo mutations in TLK2, leading to a reduction in its expression or kinase activity. Read more

Ion channel signalling in cancer cells

Our cells constantly sense and transport ions present in their environment. From embryonic development to epilepsy to heart disease to cancer, our cells’ ability to respond to changes in the ionic microenvironment is essential for healthy ageing. Read more

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