Heterozygous mutations in HNF1B are the commonest genetic cause of human kidney malformations. Moreover, postnatally, kidney tubule physiology is deficient characterised by electrolyte (Mg2+ and K+)wasting into the urine. Read more
Background. Rare inflammatory diseases affecting the kidney, called glomerulonephritis, are a leading cause of kidney failure and current treatments are unable to achieve disease control in everyone. Read more
Chronic kidney disease (CKD) is a major public health emergency. 7 million people in the UK have CKD, numbers are expected to increase over the next 10 years, with a major impact on the UK health economy (1). Read more
Research interests/description of main research theme. Patients with chronic kidney disease are 40% more likely to develop cardiovascular disease, however, mechanisms driving the cardiovascular pathogenesis are unclear. Read more
Steroid Resistant Nephrotic syndrome (SRNS) is a rare kidney condition which causes excess fluid to be retained in the body which causes swelling (oedema). Read more
Eukaryotic cells employ a carefully coordinated network of signalling and repair proteins to resolve DNA damage, known as the DNA damage response (DDR). Read more
Patients with end stage kidney disease receiving haemodialysis treatment have the highest rates of mortality, cardiovascular disease (CVD), and symptom burden across all of the stages of chronic kidney disease (CKD). Read more
Myxozoan parasites are an unusual group of basal metazoan parasites causing severe disease in farmed fish species. Tetracapsuloides bryosalmonae causes proliferative kidney disease (PKD) in salmonid fish throughout Europe and USA. Read more
'TO APPLY, PLEASE CLICK INSTITUTION WEBSITE'. Project background. The management of chronic diseases, including diabetes, accounts for 50% of clinical biochemistry testing. Read more
'TO APPLY, PLEASE CLICK INSTITUTION WEBSITE'. Outline & aim. To cure human disease, models are needed to provide better understanding, and to identify possible treatments. Read more
Obesity is a risk factor for many chronic metabolic diseases including heart failure and chronic kidney disease. Our lab demonstrated a tight association between increased deposition of extracellular matrix components (e.g. Read more
'TO APPLY, PLEASE CLICK INSTITUTION WEBSITE'. Background. Despite major advances in cardiovascular health, hypertension remains the risk factor contributing most to the overall burden of disease globally. Read more
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