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metabolism PhD Projects, Programs & Scholarships

We have 171 metabolism PhD Projects, Programs & Scholarships

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We have 171 metabolism PhD Projects, Programs & Scholarships

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Investigating metabolism in cardiac disease using human pluripotent stem cells

Background. Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Cardiomyocytes rely on specialised metabolism to meet the high energy demand of the heart. Read more
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Precision Medicine DTP - The long-term impact of acute respiratory viral infection: Using macrophage metabolism as a stratification tool

Background. Several acute lung infections leave a long-term impact on the lung, altering future susceptibility to disease. Previous infection history is therefore a key component of our individual response to new infection, and an important contributor to personalised medicine. Read more

Targeting steroid metabolism to block colorectal cancer proliferation

Our group is a world leader in targeting specific aspects of steroid metabolism to block cancer growth. Our research has been instrumental in the successful pre-clinical and clinical development of various novel anti-cancer compounds. Read more

Investigating the Role of the Methyl Citrate Cycle in Mycobacterial Energy Metabolism and Potential Value as a Novel Target for Antimicrobial Inhibition

Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex, is a disease of global importance1. TB remains the leading cause of death from any single infectious pathogen, and despite control efforts, there is rising incidence of multi-drug resistance (MDR). Read more

Non-invasive cardiac metabolism assessment using ultra-high field (7T) MR Spectroscopy

My group at the Oxford Centre for Clinical Magnetic Resonance Research (OCMR) is focused on development of new methods for cardiac metabolism assessment using magnetic resonance spectroscopy (MRS). Read more

Rhythmic control of energy balance - to understand how our internal clocks regulate energy metabolism

24-hour rhythms are present in virtually all aspects of our behaviour and physiology. These rhythms are underpinned by circadian clocks that run throughout the body, and act within each tissue to orchestrate many organ functions and rhythmic activities (e.g. Read more

How regulatory immunological cues (re)programme cellular metabolism to control effector T cell behaviour and function

Upon activation a T cell transitions from a state of semi-quiescence to a state of high activity. During the process of activation the T cell therefore needs to up regulate metabolic pathways to acquire the energy and nutrients required to facilitate the behavioural changes associated with its new functional state. Read more

Mechanistic computational modelling of human glioblastoma metabolism

Glioblastoma is the most common and the most lethal malignant brain tumor. In vitro cell culture of glioma cells is essential for the discovery and development of novel anticancer treatments. Read more

A role for cholesterol metabolism in neurodevelopmental disorder

Microdeletions and duplications of the chromosome 15q11.2 region have been identified as a high penetrant risk copy number variance (CNV) to autism and schizophrenia. CYFIP1 (Cytoplasmic FMR1-interacting protein 1) is generally believed to be the causal risk gene in this CNV. Read more

Immunotherapy: Manipulating T cell metabolism to improve anti-tumour immunity

The induction of immune responses to tumours can provide long-lasting protection from cancer. In this regard, T cells can suppress tumour growth by directly killing cancer cells and by producing inflammatory cytokines. Read more

Cancer: Inhibiting cell metabolism to enhance tumour cell death

All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. Read more

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