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metabolism PhD Projects, Programmes & Scholarships

We have 131 metabolism PhD Projects, Programmes & Scholarships

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We have 131 metabolism PhD Projects, Programmes & Scholarships

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Design, synthesis and evaluation of protease-activated anti-cancer prodrugs

  Research Group: Institute of Cancer Therapeutics
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more

Deciphering the role of white and brown adipocytes in metabolic disease

Our work focuses on understanding how obesity drives the development of type 2 diabetes and cardiovascular disease. Specifically, it aims to decipher molecular determinants of adipocyte number and distribution within the body; key factors of susceptibility to obesity-associated cardiometabolic diseases. Read more

Evaluation of MCT1s role in chromatin remodelling and metabolomics changes involved in cancer progression

Monocarboxylate transporter 1 (MCT1) is a transmembrane protein involved in cell metabolism and mediates transport of monocarboxylates (such as pyruvate {a metabolic substrate} and lactate {a metabolic by product}) in and out of the cell. Read more

Cutting off the fuel supply to calcium pumps in pancreatic cancer: a novel therapeutic strategy

Background and Rationale. Pancreatic ductal adenocarcinoma (PDAC) has the poorest survival and limited treatment options. Therefore, the search for novel therapeutic targets and drugs designed to selectively kill PDAC cells must remain a central research strategy. Read more

Targeting the MAPK scaffold protein KSR1 for the treatment of prostate cancer

  Research Group: Institute of Cancer Therapeutics
Prostate cancer is one of the leading causes of male cancer deaths. It arises when individual cells escape their normal growth control mechanisms and proliferate in an uncontrolled fashion. Read more

Development of a Long Acting Parathyroid Hormone Fusion for the Treatment of Hypoparathyroidism

Parathyroid hormone (PTH) is an 84 aa peptide produced by the parathyroid glands and is responsible for calcium homeostasis. Hypoparathyroidism is a rare condition in which the parathyroid glands are either absent or damaged and therefore cannot produce any or sufficient amounts of parathyroid hormone. Read more

Chrono-Vac: Harnessing the chronobiology of skin dendritic cells to boost vaccine efficacy

Project Description. How an individual responds to a vaccine can depend on what time of day that individual was vaccinated. This is evident across a number of vaccines for infectious disease including the COVID-19 vaccines. Read more

Laser Spectrometry Development for Isotopic Analysis in Environmental and Medical Applications

Summary. This is a fully-funded PhD opportunity based at NPL (London) that will investigate and establish laser spectrometry for measurement of stable isotope ratios and radiocarbon in carbon dioxide and methane, relevant for environmental monitoring and drug discovery applications. Read more

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