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We have 54 mice PhD Projects, Programmes & Scholarships for Self-funded Students

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mice PhD Projects, Programmes & Scholarships for Self-funded Students

We have 54 mice PhD Projects, Programmes & Scholarships for Self-funded Students

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Study of early pathological changes in calcified cartilage in osteoarthritis and alkaptonuria

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
We are seeking a motivated individual to work on this exciting project investigating the role that the calcified cartilage has in rare and common joint osteoarthritis, using novel approaches such as gene silencing and establishment of a 3D chondrocyte cell culture model. Read more
 Supervisor: Dr JH Hughes
 10 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Delineating the IRF6 regulatory network driving periderm formation and function

The University of Manchester Faculty of Biology, Medicine and Health
During development, the ectoderm passes through a series of cell states to produce a self-replenishing, multi-layered epidermis. Initial stratification forms a single-cell layer of flattened periderm cells which act as a barrier to prevent pathological adhesions during embryogenesis. Read more
 Supervisors: Prof M Dixon, Dr J Dixon
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Urokinase-plasminogen activator as a target to block osteoarthritic cartilage destruction

University of Liverpool Institute of Life Course and Medical Sciences
Osteoarthritis (OA) is one of the major causes of disability globally, which is particularly significant in an ageing population. Read more
 Supervisor: Dr D Wilkinson
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc By Research: Using hypomethylating agents to prevent respiratory infections in older adults

Aberdeen University School of Medicine, Medical Sciences & Nutrition
The MSc by Research programme at the University of Aberdeen is for students interested in a research-intensive master's degree. It is designed specifically to enhance your skills for a PhD or research career. Read more
 Supervisors: Dr c Quin, Prof H Wilson
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The Role of Reactive Sulfur Species in the Ageing Heart

University of Leicester Molecular and Cell Biology
Second Supervisor. Prof Melanie Madhani, University of Birmingham. Background . Ageing is a natural and complex biological process that involves the gradual deterioration of cells, tissues, and organ systems over time, thus leading to an increased susceptibility to diseases and mortality. Read more
 Supervisor: Dr C Switzer
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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The effect of early-life stress on cardiac function in later life

University of Dundee School of Medicine
Stressful experiences in early childhood can increase the risk of cardiovascular disease (CVD) in later life. How early-life stress (ELS) influences susceptibility to CVD onset remains largely unknown. Read more
 Supervisors: Dr N Fraser, Dr C Murdoch, Prof T Hales
 30 June 2024  PhD Research Project  Self-Funded PhD Students Only
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How does early life influence the brain and behavioural profile of a mouse model for schizophrenia

Cardiff University Cardiff School of Medicine
Hodge Centre for Translational Neuroscience. “Towards innovative treatments for mental illness”. Cardiff University Neuroscience and Mental Health Innovation Institute. Read more
 Supervisor: Prof A R Isles
 7 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Protecting cells from mechanical stress: A novel role of cell-surface receptor LRP1 in extracellular matrix- nuclei communication.

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
Cellular adaptation to mechanical strain (mechano-adaptation) is increasingly understood to be conferred by Lamin intermediate filament proteins located within the nuclear lamina. Read more
 Supervisor: Dr K Yamamoto
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Funded PhD - Determining the genetic and circadian basis of bipolar disorder

University of Bristol School of Physiology, Pharmacology & Neuroscience
This project will be part of the University of Bristol - University of Kent Cotutelle Programme. It will be jointly supervised by Prof James Hodge (http://www.bristol.ac.uk/phys-pharm-neuro/people-new/hodge/) and Dr Alice French at the University of Bristol, and by Prof Gurprit Lall at University of Kent. Read more
 Supervisors: Prof J Hodge, Dr AF French
 12 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Treatment of Breast Cancer and Preventing Relapse

Medical University of Vienna Institute for Pathophysiologie and Allergy
The doctoral candidate (DC) The DC will perform biological basic research on cancer in vitro and in vivo at the CIMUS-University of Santiago de Compostela (Spain). Read more
 Supervisor: Prof RPF Pérez-Fernández
 29 April 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Investigations into the protective actions of CBD in the early synaptic deficits in dementia.

University of Dundee School of Medicine
Accumulation of hyper-phosphorylated tau is a key event in Alzheimer’s disease (AD). Aberrant changes in tau cause synaptic abnormalities and cognitive deficits in early AD. Read more
 Supervisor: Prof J Harvey
 30 June 2024  PhD Research Project  Self-Funded PhD Students Only
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Translating protection of cell-surface receptor LRP1 into potential disease-modifying therapies for osteoarthritis.

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
Osteoarthritis (OA) causes pain and disability and is the most prevalent age-related joint disorder worldwide but there are no disease-modifying drugs available. Read more
 Supervisors: Dr K Yamamoto, Prof G Bou-Gharios
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Exploring tyrosine metabolism as a source of oxidative stress

University of Liverpool Institute of Life Course and Medical Sciences
We are seeking a motivated researcher to work on a pioneering project investigating the role of oxidative stress associated with tyrosine metabolism. Read more
 Supervisors: Dr BN Norman, Dr JH Hughes, Prof L Ranganath
 Year round applications  PhD Research Project  Funded PhD Project (UK Students Only)
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Endothelial glycocalyx damage as a therapeutic target in sepsis-associated Acute Kidney Injury

University of Bristol Bristol Medical School
Sepsis is the leading cause of acute kidney injury (sAKI), associated with high morbidity and mortality.1,2 Unfortunately, there is no treatment for sAKI, current therapies are nonspecific and supportive of the vital organ systems in the hope the kidney will recover. Read more
 Supervisor: Prof S Satchell
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the cellular functions of Trappc9 in brain development and microcephaly

University of Liverpool Institute of Systems, Molecular and Integrative Biology
This PhD project will investigate the cellular functions of the Trafficking protein particle complex subunit 9 (Trappc9) and its roles in brain development. Read more
 Supervisors: Dr A Plagge, Dr T Zech
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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