mouse PhD Projects, Programmes & Scholarships for Self-funded Students

We have 93 mouse PhD Projects, Programmes & Scholarships for Self-funded Students

Relationship between IFNγ-dependent tumour escape and immunotherapy

University of Oxford Kennedy Institute of Rheumatology

Tumours actively escape the immune system by inducing an immunosuppressive state whereby intra-tumoural CD8 T-cells are “exhausted”, lacking effector functions. Read more

Supervisors: Dr A Gérard, Dr C Leung

3 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Activity driven mechanisms of cerebral cortex development in the pathogenesis of intellectual disabilities and schizophrenia

Cardiff University Cardiff School of Medicine

Hodge Centre for Translational Neuroscience. “Towards innovative treatments for mental illness”. Cardiff University Neuroscience and Mental Health Innovation Institute. Read more

Supervisor: Dr FB Bedogni

7 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Development of LA1011 for high affinity binding to Hsp90 for use towards healthy ageing in patients showing Alzheimer’s symptoms

University of Sussex School of Life Sciences

Research Group: Biochemistry

With 50 million global cases of Alzheimer’s disease (AD) and care costs of 1 trillion UK pounds (expected to triple by 2050), there is a pressing need to slow disease progression, sustain productive lives and reduce costs. Read more

Supervisor: Dr C Prodromou

5 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Translating protection of cell-surface receptor LRP1 into potential disease-modifying therapies for osteoarthritis.

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Osteoarthritis (OA) causes pain and disability and is the most prevalent age-related joint disorder worldwide but there are no disease-modifying drugs available. Read more

Supervisors: Dr K Yamamoto, Prof G Bou-Gharios

Year round applications PhD Research Project Self-Funded PhD Students Only

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Elucidation of a new pathological mechanism for brittle bone disease

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

The incidence of the brittle bone disease osteogenesis imperfecta (OI) is estimated to be around 1 in 10,000 individuals. The phenotypic spectrum of OI ranges from mild to perinatal lethal and includes extra-skeletal connective tissue manifestations. Read more

Supervisor: Dr EG Laird

Year round applications PhD Research Project Self-Funded PhD Students Only

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Alterations in reparative dentinogenesis with ageing, gender and genetic predisposition

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Dental pulp exposure caused by tooth decay or injury can lead to life-threatening infections. Following injury, reparative dentinogenesis serves a vital purpose through the accelerated generation of tertiary dentine, comprising mineral and type I collagen. Read more

Supervisors: Dr EG Laird, Dr N Longridge, Prof FJ Jarad

Year round applications PhD Research Project Self-Funded PhD Students Only

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Uncovering the mechanochemical signalling inputs that drive gastruloid axial patterning

University of Liverpool Institute of Life Course and Medical Sciences

How the early mammalian embryo converts a mass of identical cells in an organism with multiple axes of symmetry (anteroposterior, dorsoventral, mediolateral) is a critical question in developmental biology. Read more

Supervisor: Dr D Turner

Year round applications PhD Research Project Self-Funded PhD Students Only

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Is there a Role for Activated Akt in Palatogenesis?

University of Dundee Dental School

Main Aim. The project will use a medial edge epithelial (MEE) cell line as an in vitro model. These cells will be used to investigate the effects of exogenous TGFβ-3 and activation of Akt on cell migration, epithelial to mesenchymal transition (EMT) and apoptosis. Read more

Supervisors: Dr S. J. Jones, Dr M Islam

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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Interdisciplinary investigation of the role of amino acids in immunometabolic responses to metformin in human cells

University of Dundee School of Medicine

There is overwhelming evidence that inflammation contributes to the development of cardiovascular disease (CVD) but counterbalancing this is evidence from meta-analysis of randomised control trials that many existing anti-inflammatory drugs, such as COX2 inhibitors and anti-TNF drugs, tend if anything to exacerbate risk of CVD. Read more

Supervisors: Prof G Rena, Prof C Lang

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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Computational modelling to understand the key drivers of placental evolution

University of Southampton Faculty of Engineering and Physical Sciences

Supervisory Team. Bram Sengers (SoE), Rohan Lewis (Medicine). Project description. This project will use computational modelling in combination with 3D multiscale multimodal imaging to improve our understanding of placental evolution, in close collaboration between Engineering and Medicine. Read more

Supervisor: Dr B Sengers

31 August 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Role of primary cilia in skeletal muscle stem cells and muscle regeneration

University of Sheffield School of Biosciences

Primary cilia are cellular organelles present at the surface of many cell types in vertebrates. In recent years, they have been shown to play essential roles in relaying signalling information from the environment to the cell. Read more

Supervisor: Dr A G Borycki

Year round applications PhD Research Project Self-Funded PhD Students Only

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Control of skeletal muscle regeneration and aging by cell signalling

University of Sheffield School of Biosciences

The ability of skeletal muscles to regenerate in response to injury, exercise, growth or disease depends on a population of adult skeletal muscle stem cells. Read more

Supervisor: Dr A G Borycki

Year round applications PhD Research Project Self-Funded PhD Students Only

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Therapeutic resolution of pulmonary arterial hypertension (PAH) by natural products

University of Bradford Faculty of Life Sciences

Research Group: Pharmacology and Experimental Therapeutics

Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death. Read more

Supervisors: Dr T Nasim, Prof C Wright

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identifying cognitive and biochemical changes underlying lifestyle risk factors for dementia

University of Bradford Faculty of Life Sciences

Research Group: Pharmacology and Experimental Therapeutics

Dementia describes a group of age-associated conditions of which cognitive decline is a major feature. Alzheimer’s disease (AD) is the most common cause of dementia and is characterised by the onset of a gradual cognitive decline. Read more

Supervisors: Dr S McLean, Dr R Williamson

Year round applications PhD Research Project Self-Funded PhD Students Only

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Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer

University of Bradford Faculty of Life Sciences

Research Group: Institute of Cancer Therapeutics

Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up of resistance to cancer drugs during treatment (‘acquired resistance’) such that over time the drugs stop working. Read more

Supervisors: Dr S Shnyder, Dr S Kantamneni

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 93 mouse PhD Projects, Programmes & Scholarships for Self-funded Students

mouse PhD Projects, Programmes & Scholarships for Self-funded Students

We have 93 mouse PhD Projects, Programmes & Scholarships for Self-funded Students

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