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We have 38 neurodegeneration PhD Projects, Programmes & Scholarships for Self-funded Students

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neurodegeneration PhD Projects, Programmes & Scholarships for Self-funded Students

We have 38 neurodegeneration PhD Projects, Programmes & Scholarships for Self-funded Students

Investigating lysosomal (dys)function in ageing and neurodegeneration

Project Overview. Ageing is associated with a decline in the functions of an organism (López-Otín, C. et al. Cell, 2023) and correlates with an increased risk of developing diseases in the later life (Niccoli, T. Read more

Exosome biogenesis and organelle trafficking in neurodegeneration.

Scientific summary. Intracellular transport pathways are fundamental for cell structure and function. Due to their longevity, complex morphology (long axonal and dendritic extensions) and requirement to maintain synaptic transmission, neurons are heavily dependent upon intracellular transport. Read more

Applied optogenetics to study the influence of neuronal activity on neurodegeneration

Neurodegenerative diseases represent a significant and growing challenge to global health, affecting millions worldwide. Despite extensive research efforts, the underlying mechanisms of neurodegeneration are not fully understood, and there is a critical lack of effective treatments. Read more

Ion channel regulation in models of neurodegeneration

Ion channels are important regulators of cellular physiology. There is now growing awareness that these proteins are invovled in pathological states, with relation to neurodegeneration voltage-gated potassium and voltage-gated calicum channels have been implicated. Read more

Investigating Lysosomal Dysfunction in Ageing and Neurodegeneration

Lysosomes are key cellular organelles that degrade and recycle macromolecules, act as signalling hubs and are implicated in many diseases including Parkinson’s disease (PD) and Alzheimer’s dementia (AD) where old age is a major risk factor. Read more

Investigating how mitochondrial dynamics control mtDNA homeostasis and engineering tools to visualise mtDNA molecules

Mitochondria are dynamic organelles forming a specific network by membrane remodeling events according to cellular needs1. Mitochondria contain multiple copies of their own genome, mtDNA, a circular molecule that encodes essential proteins involved in cellular energy production. Read more

Investigating how mitochondrial dynamics control mtDNA homeostasis and engineering tools to visualise mtDNA molecules

Mitochondria are dynamic organelles forming a specific network by membrane remodeling events according to cellular needs1. Mitochondria contain multiple copies of their own genome, mtDNA, a circular molecule that encodes essential proteins involved in cellular energy production. Read more

MScR: Probing the projections of different types of dopamine neurons

What makes one neuron different from another? How can we define different “types” of cells? Are cell types important?. In Parkinson’s disease some dopamine neurons seem to be more vulnerable to neurodegeneration. Read more

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