Accumulation of misfolded proteins and aberrant protein aggregates are hallmarks of a wide range of pathologies such as neurodegenerative diseases and cancer. Read more
The deposition of misfolded proteins is a defining feature of many age-dependent human diseases, including the increasingly prevalent neurodegenerative diseases. Read more
In psychiatry, the selection of antipsychotics and antidepressants is led by a trial-and-error approach. The prescribing of these medications is complicated by sub-optimal efficacy and high rates of adverse drug reactions (ADRs). Read more
Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more
The application of emerging technologies such as artificial intelligence, digital twin, blockchain, and the internet of things are growing fast, and their integration with complex manufacturing systems enables effective digitalisation and automation transition. Read more
Supervisor. Prof. Rita Horvath . Co-supervisor: Dr. Daniel Lagos . Mitochondria are specialised cell organelles which transform nutrients into energy. Read more
Inflammatory arthritis (IA) can result from non-autoimmune diseases (like crystal arthritis) and from autoimmune diseases like rheumatoid arthritis (RA) and spondyloarthropathies (inc. Read more
This project is one of a number that are in competition for funding from the GW4 BioMed2 MRC Doctoral Training Partnership which is offering up to 21 studentships for entry in September 2025. Read more
Membrane fouling – the deposition of organic and inorganic matter on the membrane surface – is a major technical obstacle affecting membrane-based water treatment processes. Read more
The MRC Protein Phosphorylation and Ubiquitylation Unit is a world-famous centre for the study of cell signaling and how disruption to signaling pathways causes human disease. Read more
Solid state device fabrication underpinning semiconductor and quantum technology [1] relies heavily on etching and deposition techniques based on plasma chemical vapour deposition (CVD) [2,3]. Read more
Ubiquitination is a fundamental post-translational modification (PTM) crucial for a wide range of cellular processes, including protein degradation, localization, quality control, DNA repair, cell signalling, and immune responses. Read more
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