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rnai PhD Projects, Programmes & Scholarships
We have 15 rnai PhD Projects, Programmes & Scholarships
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SELF-FUNDING MSc BY RESEARCH PROJECT: In vivo characterisation of novel risk genes for Alzheimers disease identified by Genome Wide Association Studies
Genome Wide Association Studies (GWAS) for Alzheimer’s disease (AD) have identified a number of genes that are significantly associated with the disease (van der Kant et al., 2019). Read more
MSc by Research: Genetic interactions and novel genes that regulate lignin biosynthesis and straw quality in barley
Lignin is a major component of plant cell walls, and has a significant influence on the digestibility and uses of plant biomass. The lignin biosynthesis pathway has been one of the most intensively studied plant metabolic pathways over the past two decades. Read more
Deciphering a novel anti-ageing epigenetic programme
Over two decades of intense research in the field of epigenetics have produced compelling evidence that chromatin modifications are crucial for processes such as DNA repair, transcription, splicing, mitosis, meiosis, and in the preservation of the epigenetic memory of cells. Read more
Understanding regulation of gene expression during development via an integrated computational analysis of ‘omics data
Embryonic development requires exquisite control of the expression of large numbers of genes, integrating components from the genome, transcriptome and proteome. Read more
Secrets of secretion: the role of Klu-targets in entero-endocrine cell differentiation in flies and humans
The entero-endocrine cells of the gut make up the largest endocrine organ. The hormones produced by these cells play a pivotal role in the overall regulation of organism physiology. Read more
Identifying novel regulators of haematopoiesis using flies
Supervisors. Iwan Evans (primary supervisor); Steve Brown (Biosciences, secondary supervisor). Project details. Control of blood cell proliferation, survival and activation is critical to the health of an organism. Read more
Investigating the cell biology of Neoparamoeba perurans, a causative agent of Amoebic Gill Disease, and its endosymbiont kinetoplastid, Perkinsela.
Amoebic gill disease (AGD), caused by the opportunistic amoebozoan parasite Neoparamoeba perurans, is a major disease in salmonid aquaculture [1-3] and there is an urgent need to mitigate the impact parasitic infections have on both fish welfare and sustainable growth in the sector. Read more
To investigate novel interacting drug combinations in the treatment of Ovarian Cancer
Ovarian cancer (OC), the most lethal gynaecological cancer, will result in ~13,000 deaths in the UK this year. At time of diagnosis most patients (58%)… Read more
How does twitchy link to ciliary function in sperm cells
Cilia are hair-like structures that project from the surface of cells and act as “cellular antennae,” sensing and relaying information from the environment. Read more
Basal stem cells in the lung and their recognition of dying cells
Stem cell division and differentiation is critical for barrier repair following inflammation, but the initial trigger for this process is unknown. Read more
Regulation of variant antigen gene expression in African trypanosomes
We investigate the molecular biology of African trypanosomes, with a particular focus on the epigenetic control of gene expression. Trypanosomes are… Read more
Towards the application of triplex-forming oligonucleotides as therapeutic agents
Synthetic oligonucleotides are short strands of DNA that can be used to treat or manage a wide range of diseases, for example by gene silencing. Read more
Preparing the acid bath: how epidermal growth factor receptor (EGFR) controls its own down-regulation
Signalling by cell surface receptors determines nearly every aspect of the cell’s response to its environment. Endosomes are hubs for regulating these signalling pathways. Read more
Characterisation of enhanced bacterial immunotherapy to treat colorectal cancer
Theoretically, RNA interference to reduce oncogene expression is an attractive therapeutic intervention to reduce tumour burden. Read more
Cell biology of influenza A virus infections: Mechanistic research at the interface of virus entry and host proteins and processes.
Viruses are obligatory parasites that hijack cellular functions to survive. Virus entry - the steps before viral replication begins -is regulated by multitude of host proteins and processes that interact with the incoming virus. Read more
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