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We have 232 vivo PhD Projects, Programmes & Scholarships for Self-funded Students

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vivo PhD Projects, Programmes & Scholarships for Self-funded Students

We have 232 vivo PhD Projects, Programmes & Scholarships for Self-funded Students

Investigating the mechanisms for cardiac fibrosis development and reversal

Research interests/description of main research theme. Fibrosis is a hard to treat condition of major socioeconomic importance, with ~45% of all deaths in the developed world being attributed to some type of chronic fibro-proliferative disease and is exemplified by heart disease. Read more

Cancer: Characterization of EGFR signaling activated by the endothelium in the process of breast cancer metastasis to the brain

The Epidermal Growth Factor Receptor (EGFR) is important in normal physiology regulating epithelial development and homeostasis. In cancer, deregulation resulting from mutation, amplification or transcriptional upregulation promotes tumorigenesis. Read more

Molecular mechanisms underlying the anti-atherogenic actions of natural products

Atherosclerosis, the underlying cause of myocardial infarction, stroke and peripheral vascular disease, is responsible for most deaths in the western world with mortality increasing at a marked rate in developing. Read more

Feeding microbes to protect the brain: does the gut microbiota mediate the risk-reducing effects of a healthy diet on Alzheimer’s disease?

Background. Ways of reducing the risk of developing Alzheimer’s disease (AD) and other dementias are critically needed, given the almost total lack of truly effective therapeutic options, even despite newer anti-amyloid drugs1. Read more

Cancer: Inhibiting cell metabolism to enhance tumour cell death

All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. Read more

Investigating how mitochondrial dynamics control mtDNA homeostasis and engineering tools to visualise mtDNA molecules

Mitochondria are dynamic organelles forming a specific network by membrane remodeling events according to cellular needs1. Mitochondria contain multiple copies of their own genome, mtDNA, a circular molecule that encodes essential proteins involved in cellular energy production. Read more

Investigating how mitochondrial dynamics control mtDNA homeostasis and engineering tools to visualise mtDNA molecules

Mitochondria are dynamic organelles forming a specific network by membrane remodeling events according to cellular needs1. Mitochondria contain multiple copies of their own genome, mtDNA, a circular molecule that encodes essential proteins involved in cellular energy production. Read more

Neurovascular coupling in cerebral hypoperfusion

There are almost a million people living with dementia in the UK. Most of these cases comprise Alzheimer’s Disease (AD), vascular dementia (VaD) or, as is increasingly recognised, a mixed picture phenotype with evidence of the two conditions co-existent in the same patient. Read more

Untangling how Shelterin safeguards telomere structure and stability - one molecule at a time

Background. Telomeres solve two problems with linear chromosomes. the end-replication problem, DNA loss from the end of chromosomes every replication cycle; and the end-protection problem, protection of the chromosome ends to prevent chromosome fusions. Read more

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