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Biochemistry PhD Projects, Programs & Scholarships in Sheffield

We have 47 Biochemistry PhD Projects, Programs & Scholarships in Sheffield

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  Investigating the role of N-type glycosylation in protein-ligand interactions using a unique commercial microarray technology
  Dr J Pandhal, Prof MJ Dickman
Applications accepted all year round

Funding Type

PhD Type

Over recent years microarray technology has been instrumental in expanding knowledge of the interactions between proteins and both synthetic and natural ligands, contributing to substantial advances in the global biopharmaceutical industry.
  Early Stage Researcher (PhD Student) position in ecology and ecotoxicology.
  Prof L L Maltby, Prof P Warren
Application Deadline: 31 May 2020

Funding Type

PhD Type

Understanding the potentially negative impacts of chemicals on ecosystems is essential to managing them sustainably. In particular, we need to understand the effects of chemicals on the direct and indirect contributions that ecosystems make to human well-being (i.e.
  Designing new molecules against Alzheimer’s disease using artificial intelligence techniques
  Dr A de la Vega de Leon, Prof B Chen
Application Deadline: 1 June 2020

Funding Type

PhD Type

The Sheffield Chemoinformatics Research Group is pleased to offer a fully-funded 3.5 year PhD studentship.
  Treating cancer by targeting the mechanical properties of cells
  Dr A Gad
Applications accepted all year round

Funding Type

PhD Type

Cancer development is marked by massive increase of matrix fibres around tumor cells, which changes the mechanical properties of the tissue and is used to diagnose tumours by manual palpation.
  EPSRC CDT in Advanced Biomedical Materials

Funding Type

PhD Type

Applications are invited from qualified graduates for fully-funded four-year PhD studentships in the area of Advanced Biomedical Materials.
  Disease phenomics - quantifying the development of disease symptoms in infected plants
  Dr S A Rolfe
Applications accepted all year round

Funding Type

PhD Type

Biology is undergoing a revolution as ‘omic technologies allow us to make hundreds or thousands of measurements on large populations of plants.
  How does clubroot obtain nutrients from its living plant host?
  Dr S A Rolfe
Applications accepted all year round

Funding Type

PhD Type

Clubroot is an important pathogen of Brassica crops. The disease is found throughout the world and causes severe economic losses.
  Addressing the functional significance of distinct paths to catalytic sites within the exosome
  Dr P Mitchell
Applications accepted all year round

Funding Type

PhD Type

The exosome RNase complex contains two associated catalytic subunits, one of which has two distinct catalytic sites (Mitchell, 2014).
  Analysis of the exoribonuclease Rex1
  Dr P Mitchell
Applications accepted all year round

Funding Type

PhD Type

Inhibition of one exosome catalytic subunit renders cells dependent upon another RNase called Rex1.
  Bactofilins and the bacterial cytoskeleton
  Dr E Hoiczyk
Applications accepted all year round

Funding Type

PhD Type

Newly developed light and electron microscopy methods are revolutionising our understanding of bacterial cells. Once thought to be simple, bacteria have now been recognised at highly organised cells using many elements previously only known from eukaryotes.
  Dissecting the mechanisms of antibiotic resistance in Clostridium difficile
  Dr R Fagan
Applications accepted all year round

Funding Type

PhD Type

Antibiotic resistance in pathogenic bacteria is one of the greatest health challenges facing humanity today.
  Gliding motility in bacteria
  Dr E Hoiczyk
Applications accepted all year round

Funding Type

PhD Type

Motility is important for bacterial survival and facilitates colonisation and dispersal of bacteria. While swimming and type IV pili-based swarming is relatively well understood, gliding or adventurous motility, a form of surface-associated motility is still enigmatic.
  Investigating the molecular basis of this adhesion and the development of tetraspanin-based reagents for preventing bacterial infections
  Dr L J Partridge
Applications accepted all year round

Funding Type

PhD Type

The tetraspanins are a diverse, conserved family of eukaryotic membrane proteins. Their principal feature is the ability to form dynamic multi-molecular assemblies in cell membranes known as tetraspanin enriched microdomains (TEM).
  Optimisation of gene expression routes for heterologous protein expression in CHO cells
  Dr P Mitchell
Applications accepted all year round

Funding Type

PhD Type

CHO cells are commonly used as a vehicle for the production of heterologous proteins in the biopharmaceutical industry. We are currently using gene knock down and knock in approaches to increase the expression level of target recombinant proteins for potential use in industrial scale applications.
  Photoreceptor regulation of plant development
  Dr S Casson
Applications accepted all year round

Funding Type

PhD Type

Plant growth and development is highly dependent on the light environment. Light provides energy to drive photosynthesis but light quality and quantity is also perceived by photoreceptors, which signal to regulate responses enabling plants to adapt to their environment.
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