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Bioinformatics PhD Projects, Programs & Scholarships in Sheffield

We have 18 Bioinformatics PhD Projects, Programs & Scholarships in Sheffield

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Showing 1 to 10 of 18
  Longitudinal study on the relationship of the gut microbiome to disease progression in the UK MND population
  Prof C McDermott, Dr S Boddy
Applications accepted all year round

Funding Type

PhD Type

Motor neurone disease (MND) is a devastating neurodegenerative condition characterised by progressive deterioration of motor functions until death normally results from respiratory failure.
  TRIB3 at the interface of metabolism and inflammation in adipose tissue
  Dr H Wilson, Prof E Kiss-Toth
Applications accepted all year round

Funding Type

PhD Type

Obesity drives chronic inflammation and immune activation. This results in dysregulated metabolism, insulin resistance linked to diabetes, cardiovascular disease and cancer.
  Identifying inhibitors specific to the OPG-kinome: towards novel treatments for Pulmonary Arterial Hypertension (PAH).
  Prof A Lawrie, Dr R Thompson
Applications accepted all year round

Funding Type

PhD Type

Background. Pulmonary arterial hypertension (PAH) is a fatal progressive disease. Median life expectancy in untreated PAH patients is 2.8 years.
  Application of data science to inherited genetic variants of apoptosis genes and susceptibility to breast cancer
  Prof A Cox, Dr K Walters
Applications accepted all year round

Funding Type

PhD Type

Background. The identification of the breast and ovarian cancer genes BRCA1 and BRCA2 two decades ago has resulted in both improved patient risk assessment and the use of PARP-inhibitors for treatment.
  Discover doctoral opportunities at the Information School

Funding Type

PhD Type

The Information School. A long established and highly respected department, the Information School is the number one department of its kind in Europe, and second in the world according to the QS World University Rankings by Subject 2019.
  Evolutionary origins of adaptive traits in grasses*
  Dr P A Christin
Applications accepted all year round

Funding Type

PhD Type

During evolution, grasses acquired a variety of functional traits that allowed them to colonize almost all environments around the globe, and rank amongst the most productive crops, weeds, and invasive species.
  PhD in Ecology and Environment: how ecosystems, and the species they contain, respond to environmental change and how to reduce and mitigate adverse impacts
  Dr D Childs
Applications accepted all year round

Funding Type

PhD Type

Environmental change threatens biodiversity, altering ecosystem processes and provision of ecosystem services. These environmental change pressures are accelerating due to growing human populations and accompanying climate change, land use, pollution and invasive species.
  Addressing the functional significance of distinct paths to catalytic sites within the exosome
  Dr P Mitchell
Applications accepted all year round

Funding Type

PhD Type

The exosome RNase complex contains two associated catalytic subunits, one of which has two distinct catalytic sites (Mitchell, 2014).
  Analysis of the exoribonuclease Rex1
  Dr P Mitchell
Applications accepted all year round

Funding Type

PhD Type

Inhibition of one exosome catalytic subunit renders cells dependent upon another RNase called Rex1.
  Biophysics of enzyme-catalyzed phosphoryl transfer
  Prof J P Waltho
Applications accepted all year round

Funding Type

PhD Type

Using a combination of multinuclear NMR spectroscopy, high resolution X-ray crystallography, synthetic chemistry and computational chemistry we have explored the conformational behaviour of enzymes under a very wide range of conditions.
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