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Bioinformatics PhD Projects, Programs & Scholarships in Sheffield

We have 39 Bioinformatics PhD Projects, Programs & Scholarships in Sheffield

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  BBSRC White Rose CASE studentship - Novel approaches for the identification of allosteric inhibitors of high value therapeutic targets
  Prof J P Waltho
Application Deadline: 6 January 2020

Funding Type

PhD Type

This study will develop a novel approach to identify allosteric inhibitor sites on a wide variety of high-value therapeutic targets, including protein kinases, protein phosphatases and small G-proteins.
  MRC DiMeN Doctoral Training Partnership: How do non-coding enhancer RNAs confer genetic risk in Amyotrophic Lateral Sclerosis (ALS)?
  Dr Dan Bose, Dr J Cooper-Knock
Application Deadline: 6 January 2020

Funding Type

PhD Type

Project. Amyotrophic Lateral Sclerosis (ALS) is an aggressive neurodegenerative disease with no effective therapy. The established genetic causes of ALS can only explain a small fraction of the observed disease phenotypes.
  MRC DiMeN Doctoral Training Partnership: How does the human innate immune system kill the Streptococcus pneumoniae bacterium during infection?
  Dr A Fenton, Dr L Prince
Application Deadline: 6 January 2020

Funding Type

PhD Type

Background. The bacterium Streptococcus pneumoniae is a highly successful human pathogen and a leading cause of pneumonia, a disease responsible for millions of deaths every year.
  MRC DiMeN Doctoral Training Partnership: Development of an automated analysis pipeline to study bacterial cell wall structure and resistance to beta-lactam antibiotics
  Dr S Mesnage, Dr M Collins
Application Deadline: 6 January 2020

Funding Type

PhD Type

The most widely used antibiotics ever discovered (beta-lactams) are targeting the enzymes that polymerize peptidoglycan (PG), the essential component of the bacterial cell wall.
  MRC DiMeN Doctoral Training Partnership: How to kill a difficult superbug: understanding the evolution of antimicrobial resistance in Clostridioides difficile
  Dr R Fagan, Prof M Brockhurst
Application Deadline: 6 January 2020

Funding Type

PhD Type

Increasing resistance to antibiotics is one of the greatest health challenges facing humanity today. Clostridioides difficile is the primary cause of antibiotic-associated infections in UK hospitals and antibiotic-induced disruption of the gut microbiota is a prerequisite for infection.
  MRC DiMeN Doctoral Training Partnership: Activation of Aurora Kinase A by DNA damage – understanding the signalling pathway to improve radiotherapy response
  Dr H Bryant, Prof C Eyers, Prof P Eyers
Application Deadline: 6 January 2020

Funding Type

PhD Type

Radiation is a mainstay of cancer therapy, however radioresistance is a significant challenge in the treatment of locally advanced, recurrent and metastatic cancers.
  MRC DiMeN Doctoral Training Partnership: How to kill a difficult superbug: understanding the evolution of antimicrobial resistance in Clostridioides difficile
  Dr R Fagan, Prof M Brockhurst
Application Deadline: 6 January 2020

Funding Type

PhD Type

Increasing resistance to antibiotics is one of the greatest health challenges facing humanity today. Clostridioides difficile is the primary cause of antibiotic-associated infections in UK hospitals and antibiotic-induced disruption of the gut microbiota is a prerequisite for infection.
  MRC DiMeN Doctoral Training Partnership: Killing the unkillable. Developing bacterial capture compounds to identify new targets against antimicrobial resistant Staphylococcus aureus
  Dr R Corrigan, Dr D Williams
Application Deadline: 6 January 2020

Funding Type

PhD Type

The “superbug”, Methicillin resistant Staphylococcus aureus (MRSA) is a major threat to global health. Once inside a host, bacteria, like S.
  MRC DiMeN Doctoral Training Partnership: Building integrated machine learning and genomic approaches to quantitate bone quality and fracture risk
  Prof M Wilkinson, Prof A Frangi, Prof E Zeggini
Application Deadline: 6 January 2020

Funding Type

PhD Type

Is this project for you?. This PhD Project would suit a student inspired by the prospect of participating in a truly multidisciplinary team.
  MRC DiMeN Doctoral Training Partnership: DUB-ing chronic inflammation: a drug repurposing approach to target deubiquitinases in inflammatory disease
  Dr H Ismail, Prof S Renshaw, Dr L Guo
Application Deadline: 6 January 2020

Funding Type

PhD Type

Background. Inflammation is an essential defence mechanism adapted by our bodies to eliminate damaged cells, irritants and pathogens.
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