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Biological & Medical Sciences PhD Projects, Programs & Scholarships in Sheffield

We have 175 Biological & Medical Sciences PhD Projects, Programs & Scholarships in Sheffield

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Showing 1 to 10 of 175
  Test
  Dr A Holliday, Prof D Stevenson
Applications accepted all year round

Funding Type

PhD Type

Enter project information here2.
  Oral vitamin D spray as a novel treatment for 22q11 deletion syndrome
  Dr A McNeill, Dr C Mazzà
Applications accepted all year round

Funding Type

PhD Type

22q11 deletion syndrome is the most common genetic disorder, affecting about 1/2500 people (as common as cystic fibrosis). It is due to a small missing piece of chromosome 22 on the long arm (q) at position 11.
  Neurological reserve as a pivotal mechanism for psychiatric symptoms in Alzheimer’s disease
  Prof A Venneri, Dr M De Marco
Applications accepted all year round

Funding Type

PhD Type

Patients with Alzheimer’s disease (AD) may experience and show a whole range of clinical symptoms. Of these, psychiatric symptoms such as apathy, depression and anxiety play a major role in that they are highly debilitating for patients and carers.
  The influence of Apolipoprotein E genotypes on pathways of neurotransmission measured in vivo. Implications for dementia research
  Dr M De Marco, Prof A Venneri
Applications accepted all year round

Funding Type

PhD Type

Monoaminergic midbrain nuclei are currently emerging as major players in the definition of the pathological changes of early Alzheimer’s disease (AD) stages.
  Longitudinal study on the relationship of the gut microbiome to disease progression in the UK MND population
  Prof C McDermott, Dr S Boddy
Applications accepted all year round

Funding Type

PhD Type

Motor neurone disease (MND) is a devastating neurodegenerative condition characterised by progressive deterioration of motor functions until death normally results from respiratory failure.
  Investigating the role of adenosine deaminase in motor neuron disease
  Dr S P Allen
Applications accepted all year round

Funding Type

PhD Type

In a recent study published in Brain (https://doi.org/10.1093/brain/awy353) and highlighted in a number of media articles (www.sheffield.ac.uk/news/nr/disrupted-pathway-motor-neurone-disease-1.830534) we have identified a novel disruption in an energy generating pathway in astrocytes (neuronal support cells) derived from motor neurone disease (MND) patients.
  What is the impact of atypical neurogenesis on brain activity, cognition and behaviour?
  Dr A McNeill, Dr M Freeth
Applications accepted all year round

Funding Type

PhD Type

Neurogenesis is the process by which stem cells form brain cells. This process is disrupted by genetic mutations causing childhood neurological disorders which cause symptoms such as learning disability, behaviour problems and epilepsy.
  TRIB3 at the interface of metabolism and inflammation in adipose tissue
  Dr H Wilson, Prof E Kiss-Toth
Applications accepted all year round

Funding Type

PhD Type

Obesity drives chronic inflammation and immune activation. This results in dysregulated metabolism, insulin resistance linked to diabetes, cardiovascular disease and cancer.
  Identifying inhibitors specific to the OPG-kinome: towards novel treatments for Pulmonary Arterial Hypertension (PAH).
  Prof A Lawrie, Dr R Thompson
Applications accepted all year round

Funding Type

PhD Type

Background. Pulmonary arterial hypertension (PAH) is a fatal progressive disease. Median life expectancy in untreated PAH patients is 2.8 years.
  Using the fly kidney to develop new treatments for genetic kidney diseases
  Prof A Ong, Dr N Bulgakova
Applications accepted all year round

Funding Type

PhD Type

Polycystic kidney disease is the most common hereditary cause of kidney failure in man. It comprises a spectrum of diseases of which Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common form in adults and Nephronophthisis (NPHP) the most common form in children.
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