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Biotechnology PhD Projects, Programs & Scholarships in Sheffield

We have 33 Biotechnology PhD Projects, Programs & Scholarships in Sheffield

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  Investigating the in vivo targets and mechanism of action of a toxic acetylcholinesterase-derived peptide upregulated in Alzheimer’s disease.
  Dr M Collins
Application Deadline: 6 January 2020

Funding Type

PhD Type

Project description. Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is characterised by the deposition and accumulation of amyloid beta plaques and phosphorylated tau filaments in the brain, the latter correlating with the onset of symptoms.
  BBSRC White Rose DTP iCASE - Exploring the therapeutic potential of BoNT/X
  Dr A Peden
Application Deadline: 6 January 2020

Funding Type

PhD Type

Clostridial neurotoxins are produced by anaerobic bacteria such as Clostridium botulinum. Each toxin molecule has a highly conserved zinc-dependent protease domain that has exquisite specificity for SNARE proteins, a family of molecules required for intracellular trafficking and vesicle fusion.
  Bioplastic from sustainable feedstock – tackling the plastic challenge
  Dr K Tee
Application Deadline: 15 January 2020

Funding Type

PhD Type

Plastic is used in many applications, including packaging, construction material, parts in the automotive, biomedical devices and electronic components.
  How do antibiotics kill bacteria?
  Prof S J Foster
Applications accepted all year round

Funding Type

PhD Type

Despite being a lynchpin of modern healthcare we still do not understand how cell wall active antibiotics such as penicillin and vancomycin kill growing bacteria, although several theories have been proposed.
  The regulation of Staphylococcus aureus cell division
  Prof S J Foster
Applications accepted all year round

Funding Type

PhD Type

Staphylococcus aureus is a major human pathogen causing significant death and disease around the world. The problem is exacerbated by the spread of antibiotic resistant strains.
  The role of protein turnover in bacterial life and death
  Prof S J Foster
Applications accepted all year round

Funding Type

PhD Type

The control of protein levels in bacterial cells is essential for their growth and survival. This is an interplay between protein synthesis and turnover.
  MRC DiMeN Doctoral Training Partnership: Investigating the in vivo targets and mechanism of action of a toxic acetylcholinesterase-derived peptide upregulated in Alzheimer’s disease
  Dr M Collins, Prof S Greenfield
Application Deadline: 6 January 2020

Funding Type

PhD Type

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is characterised by the deposition and accumulation of amyloid beta plaques and phosphorylated tau filaments in the brain, the latter correlating with the onset of symptoms.
  WRDTP ESRC PhD Studentships 2020/21

Funding Type

PhD Type

 . WRDTP ESRC PhD STUDENTSHIPS 2020/21.
  WRDTP ESRC PhD Studentships 2020/21

Funding Type

PhD Type

 . WRDTP ESRC PhD STUDENTSHIPS 2020/21.
  BBSRC White Rose DTP Studentship - Role of cytidine deaminase in (epi)genetic adaptation of the plant immune system.
  Prof J Ton, Dr L Smith, Dr J Stassen
Application Deadline: 6 January 2020

Funding Type

PhD Type

As sessile organisms, plants are masters in adapting to environmental stresses. Recent work from the Ton lab has shown that plants employ epigenetic mechanisms to prime their immune system long-term against potential pests and diseases.
  Plant-microbial interactions: legume-rhizobial cover crops under drought and climate change
  Prof D Cameron, Dr E Harrison, Prof J Gray, Dr C Chater
Application Deadline: 8 January 2020

Funding Type

PhD Type

To develop sustainable agriculture under climate change we need to tackle CO2 emissions and drought stress. Legume-rhizobial cover crops (leys) enhance carbon and nitrogen in soils, reducing vulnerability to drought and water pollution.
  Mechanistic Study of Molecular Assembly for Drug and Gene Delivery
  Dr X Zhao
Applications accepted all year round

Funding Type

PhD Type

Despite numerous advances over the past several decades, effective drug and gene delivery with high efficiency, low toxicity and cell targeting remains challenging.
  Reactive Inkjet Printing of Flexible Devices for Cancer Diagnostics, Environmental Monitoring and Energy Store
  Dr X Zhao
Applications accepted all year round

Funding Type

PhD Type

Flexible devices such as microfluidic paper-based analytical devices (μPADs) have recently received significant attention as a potential platform for low-cost diagnostic assays.
  Reactive Inkjet Printing of Functional Swimmers
  Dr X Zhao
Applications accepted all year round

Funding Type

PhD Type

Production of small-scale devices that can autonomously generate thrust via catalytic reactions within fluidic environments has become an increasingly active field and has led to a focus on potential applications including environmental monitoring and remediation, in vivo drug delivery and repair, and lab on a chip diagnostics.
  Development of Intronless Expression Plasmids for Biomanufacturing of Therapeutic Proteins
  Prof S A Wilson, Dr E Thomson, Dr I Sudbery
Application Deadline: 10 January 2020

Funding Type

PhD Type

Therapeutic proteins such as antibodies are a successful class of biologic drug used to treat a wide range of diseases in areas such as oncology, respiratory, inflammation, autoimmunity and cardiology.
  PhD: Improving Photosynthesis
  Prof A Fleming
Applications accepted all year round

Funding Type

PhD Type

Improving photosynthetic efficiency has been identified as one of the few remaining traits for exploitation if we are to achieve the significant increases in crop yield required to feed the projected 9 billion world population by 2050.
  Nanotribological properties of organic surfaces
  Prof GJ Leggett
Applications accepted all year round

Funding Type

PhD Type

Friction is ubiquitous in all sliding contacts. Much energy is dissipated in sliding contacts, and the minimisation of friction can make a significant contribution to the efficient use of fuels.
  Mechanisms of cell membranes repair in health and disease
  Dr B Ciani
Applications accepted all year round

Funding Type

PhD Type

Compartmentalisation of chemical reactions and packaging of genetic material is fundamental for the healthy state of any biological cell.
  Engineering Cupriavidus Necator H16 to Convert CO2/Waste Stream into Useful Chemicals Using a Synthetic Biology Approach
  Dr TS Wong
Applications accepted all year round

Funding Type

PhD Type

This project falls under the umbrella of carbon capture and utilization (CCU), i.e., to turn a greenhouse gas CO2 into a useful feedstock for chemical syntheses.
  Enzyme Engineering for Industrial Biocatalysis
  Dr TS Wong
Applications accepted all year round

Funding Type

PhD Type

Fossil fuels have long been the primary energy and carbon sources, providing the raw materials needed for the manufacture of a wide range of products that we use daily.
  Production of Industrial Chemicals for Personal Care and Health Care Using Oleaginous Yeast
  Dr TS Wong
Applications accepted all year round

Funding Type

PhD Type

Many ingredients in the personal care and health care products, for example lipids, are derived from petroleum, animal fat or vegetable oil.
  Bactofilins and the bacterial cytoskeleton
  Dr E Hoiczyk
Applications accepted all year round

Funding Type

PhD Type

Newly developed light and electron microscopy methods are revolutionising our understanding of bacterial cells. Once thought to be simple, bacteria have now been recognised at highly organised cells using many elements previously only known from eukaryotes.
  Biogenesis of the Clostridium difficile cell surface
  Dr R Fagan
Applications accepted all year round

Funding Type

PhD Type

Clostridium difficile infection (CDI) is a major cause of morbidity and mortality in our hospitals. Infection normally follows disruption of the gut normal flora by broad-spectrum antibiotic treatment.
  Development of a novel immunotoxin
  Dr L J Partridge
Applications accepted all year round

Funding Type

PhD Type

Immunotoxins represent a form of immunotherapy whereby antibodies are used to target a toxin, usually to cancer or infected host cells.
  Functional analysis of novel genes important in the physiology and pathogenesis of the human pathogen Campylobacter jejuni
  Prof D J Kelly
Applications accepted all year round

Funding Type

PhD Type

Campylobacter jejuni and E. coli are the commonest cause of human bacterial gastroenteritis worldwide. Although pathogenic in humans, C.
  Gliding motility in bacteria
  Dr E Hoiczyk
Applications accepted all year round

Funding Type

PhD Type

Motility is important for bacterial survival and facilitates colonisation and dispersal of bacteria. While swimming and type IV pili-based swarming is relatively well understood, gliding or adventurous motility, a form of surface-associated motility is still enigmatic.
  Investigating Photosynthesis in Nannochloropsis – An Important Algal Genus for Biofuel Production
  Dr D J Gilmour
Applications accepted all year round

Funding Type

PhD Type

One of the key insights from phylogenetic studies of eukaryotic microorganisms is the enormous diversity within the microalgal group with green algae being similar to plants and other groups such as diatoms being very different.
  Investigating Photosynthesis in Nannochloropsis – An Important Algal Genus for Biofuel Production
  Dr D J Gilmour
Applications accepted all year round

Funding Type

PhD Type

One of the key insights from phylogenetic studies of eukaryotic microorganisms is the enormous diversity within the microalgal group with green algae being similar to plants and other groups such as diatoms being very different.
  Optimisation of gene expression routes for heterologous protein expression in CHO cells
  Dr P Mitchell
Applications accepted all year round

Funding Type

PhD Type

CHO cells are commonly used as a vehicle for the production of heterologous proteins in the biopharmaceutical industry. We are currently using gene knock down and knock in approaches to increase the expression level of target recombinant proteins for potential use in industrial scale applications.
  Photoreceptor regulation of plant development
  Dr S Casson
Applications accepted all year round

Funding Type

PhD Type

Plant growth and development is highly dependent on the light environment. Light provides energy to drive photosynthesis but light quality and quantity is also perceived by photoreceptors, which signal to regulate responses enabling plants to adapt to their environment.
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