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Cancer / Oncology PhD Projects, Programs & Scholarships in Sheffield

We have 12 Cancer / Oncology PhD Projects, Programs & Scholarships in Sheffield

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  Development and testing of small molecule NUDT22 inhibitors for uses in cancer
  Dr T Helleday, Dr P Herr
Application Deadline: 28 February 2019
The INTEGRATA network –“Integrating chemical and biological approaches to target NAD production and signaling in cancer” – aims at providing a group of early stage researchers (ESRs) with a highly interdisciplinary and intersectoral training in drug discovery, focusing specifically on NAD production and on NAD/nucleotide signaling as targets for the development of new cancer therapeutics.
  Extracellular Vesicles: small packages with a big role in bowel cancer metastasis
  Dr N J Peake, Dr L Cole, Prof C Le Maitre
Application Deadline: 31 March 2019
Project details. Background. Patients with metastatic colorectal cancer (CRC) have poor survival rates, reflecting the difficulty in treating advanced disease.
  Investigating the role of the mechanosensor channel Piezo1 in human disease
  Dr K Erdmann
Applications accepted all year round
Piezo proteins are ion channels that are gated by mechanical stimuli like stretch or shear stress. In mammalians there are two Piezo isoforms (Piezo1 and Piezo2) with largely different expression pattern.
  Cell plasticity in development and disease
  Dr K Campbell
Applications accepted all year round
Although 90% of cancer deaths are caused by metastasis, the underlying pathogenic mechanisms are poorly understood.
  Non-coding RNA regulation of stem cells
  Dr S Brown, Dr P Gokhale
Applications accepted all year round
Stem cells have the potential to make any cell type in the Human body and are powerful tools in drug discovery (Xia and Wong, 2012).
  Syndecan-4 regulates cell migration during healing and cancer through caveolar endocytosis
  Dr M Bass
Applications accepted all year round
Cell migration during wound healing or cancer cell invasion involves responses to multiple factors including extracellular matrix and growth factors.
  Unravelling how mechanical forces build breast tissue to help tackle cancer
  Dr N Akhtar, Dr A Fletcher
Application Deadline: 28 February 2019
Project description. Disrupted tissue architecture is a central hallmark of cancer. For example, breast cancer is characterized by an abnormal growth of cells filling the hollow spaces of the tissue.
  Targeting extracellular vesicle-mediated intercellular communication in cancer through the use of 3D tissue engineered models
  Dr S Hunt, Dr H Colley
Application Deadline: 28 February 2019
Extracellular vesicles (EVs) are nanoscale sized, membrane-enclosed particles that are produced by all cells of the body. Cancer cells release more EVs, with an altered cargo, compared to normal cells.
  Using Artifical Intelligence to Predict the Behaviour and Prognosis of Head and Neck Cancers
  Dr S A Khurram, Dr S Atkins
Application Deadline: 28 February 2019
Head and Neck cancers are the 6th most common cancer in the world with an increasing incidence and worsening outcomes. In the UK alone, at least 12,000 new cases are diagnosed each year (32 per day) with over 4000 related deaths per year (11 per day).
  Exploring mechanisms of resistance to anti-angiogenic therapy in breast cancer
  Dr C Kanthou, Prof N Brown
Applications accepted all year round
Vascular endothelial growth factor (VEGF) is a potent angiogenesis inducer and is often overexpressed in cancer. Circulating levels of VEGF as well as tumour microvessel density are of prognostic value in breast cancer.
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