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Cancer / Oncology PhD Projects, Programs & Scholarships in Sheffield

We have 43 Cancer / Oncology PhD Projects, Programs & Scholarships in Sheffield

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Showing 11 to 20 of 43
  Targeting perivascular macrophages to enhance the efficacy of immunotherapy in prostate cancer
  Prof CE Lewis, Dr M Muthana
Applications accepted all year round

Funding Type

PhD Type

Immunotherapies like checkpoint inhibitors do not work well in most prostate cancer patients, with only a small group showing durable responses.
  Synthesise of new macromolecules for application in photodynamic therapy.
  Dr L Twyman
Applications accepted all year round

Funding Type

PhD Type

Photodynamic therapy (PDT) is an effective and licensed treatment for a number of conditions, including various cancers and certain skin and eye conditions.
  ’Follow my leader’: in vitro studies of oral cancer cell motility
  Dr S Whawell, Dr H Colley
Applications accepted all year round

Funding Type

PhD Type

Oral cancer cell invasion is a crucial step in the progression of the disease and is mediated by interactions with the extra cellular matrix and factors released by the tumour cells as well as cells that occupy the tumour microenvironment (stroma).
  The EV-glycome: the coming of age of a novel biomarker?
  Dr D Lambert, Dr G Stafford
Application Deadline: 29 January 2020

Funding Type

PhD Type

Cellular senescence is the permanent loss of a cell’s ability to divide. Although no longer dividing, senescent cells remain metabolically active and develop a secretory, inflammatory phenotype termed the SASP.
  Exploring the function of the cGAS-STING pathway in oral tissues: links to ageing, response to infection and oncogenesis
  Prof K Hunter, Dr D Lambert
Application Deadline: 29 January 2020

Funding Type

PhD Type

Background. The ability of cells to detect cytoplasmic DNA is an important part of the innate immune response. DNA can be present in the cytoplasm of cells if infected (viral or bacterial) and the cGAS-STING pathway is a key mechanism for the detection of and response to this DNA.
  Adrenomedullin-2 receptor antagonists in T-cell lymphoma
  Dr G Richards, Prof T Skerry
Applications accepted all year round

Funding Type

PhD Type

Cancer cells rely upon communication between themselves and to the host tissues to survive and grow. One hormone involved in cancer signalling is adrenomedullin (AM), which also has important physiological roles in the control of blood pressure.
  Targeting IL-1B to improve outcome for patients with breast cancer bone metastases.
  Dr P Ottewell
Application Deadline: 30 July 2020

Funding Type

PhD Type

Background. Breast cancer metastasis to bone is currently incurable. Treatment consists of combining anti-tumour therapies with bone strengthening agents such as zoledronic acid (ZA).
  The role of VISTA expression by tumour macrophages in limiting the efficacy of chemotherapy and checkpoint inhibitors
  Prof CE Lewis, Dr M Muthana
Applications accepted all year round

Funding Type

PhD Type

Women with triple negative breast cancer (TNBC) have limited treatment options and often rely heavily on chemotherapy. Unfortunately, many fail to show a complete response to this and suffer recurrence at the primary or distant sites within 1-3 years.
  Ex vivo drug screening using human tissue to personalise cancer therapy and replace murine avatars for high-grade brain tumours
  Prof T Helleday, Dr S Collis
Application Deadline: 31 January 2020

Funding Type

PhD Type

Supervisor(s). Principle Investigator; Prof Thomas Helleday, Co-investigators Dr. Spencer Collis, Dr. Juha Rantala, Mr. Ola Rominyi and Dr.
  Targeting novel regulators of nucleotide metabolism to treat cancer
  Dr A Green
Applications accepted all year round

Funding Type

PhD Type

1 in 2 people will be diagnosed with cancer in their lifetime. Despite modern medical advancements, cancer is the leading cause of death in the western world.
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