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Cancer / Oncology PhD Projects, Programs & Scholarships in Sheffield

We have 29 Cancer / Oncology PhD Projects, Programs & Scholarships in Sheffield

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  MRC DiMeN Doctoral Training Partnership: From Live Cells to Single-molecules: Unravelling the interplay between 3D genomic structure and gene expression
  Dr C Toseland, Dr T Craggs
Application Deadline: 6 January 2020

Funding Type

PhD Type

This studentship is focused on applying state-of-the-art single molecule imaging techniques to study the molecular basis of DNA condensation and its impact upon gene expression.
  MRC DiMeN Doctoral Training Partnership: Activation of Aurora Kinase A by DNA damage – understanding the signalling pathway to improve radiotherapy response
  Dr H Bryant, Prof C Eyers, Prof P Eyers
Application Deadline: 6 January 2020

Funding Type

PhD Type

Radiation is a mainstay of cancer therapy, however radioresistance is a significant challenge in the treatment of locally advanced, recurrent and metastatic cancers.
  How do antibiotics kill bacteria?
  Prof S J Foster
Applications accepted all year round

Funding Type

PhD Type

Despite being a lynchpin of modern healthcare we still do not understand how cell wall active antibiotics such as penicillin and vancomycin kill growing bacteria, although several theories have been proposed.
  The regulation of Staphylococcus aureus cell division
  Prof S J Foster
Applications accepted all year round

Funding Type

PhD Type

Staphylococcus aureus is a major human pathogen causing significant death and disease around the world. The problem is exacerbated by the spread of antibiotic resistant strains.
  The role of protein turnover in bacterial life and death
  Prof S J Foster
Applications accepted all year round

Funding Type

PhD Type

The control of protein levels in bacterial cells is essential for their growth and survival. This is an interplay between protein synthesis and turnover.
  MRC DiMeN Doctoral Training Partnership: DUB-ing chronic inflammation: a drug repurposing approach to target deubiquitinases in inflammatory disease
  Dr H Ismail, Prof S Renshaw, Dr L Guo
Application Deadline: 6 January 2020

Funding Type

PhD Type

Background. Inflammation is an essential defence mechanism adapted by our bodies to eliminate damaged cells, irritants and pathogens.
  MRC DiMeN Doctoral Training Partnership: Understanding the role of DRAM in infection and autophagy-related disease
  Dr J King, Dr P Elks
Application Deadline: 6 January 2020

Funding Type

PhD Type

Intracellular degradation by lysosomes is important in a wide range of diseases. The capture and degradation of cytoplasmic components by autophagy allows tumour cells to survive starvation and neurons to remove the protein aggregates associated with neurodegeneration.
  MRC DiMeN Doctoral Training Partnership: Targeting ageing mitochondrial metabolism with dietary interventions to combat colorectal cancer
  Dr M J P Simons, Dr K Campbell, Dr L Greaves
Application Deadline: 6 January 2020

Funding Type

PhD Type

Background. Colorectal cancer is the second most common cause of death by cancer in the UK. Diet in particular, impacts on colorectal cancer development.
  Mechanistic Study of Molecular Assembly for Drug and Gene Delivery
  Dr X Zhao
Applications accepted all year round

Funding Type

PhD Type

Despite numerous advances over the past several decades, effective drug and gene delivery with high efficiency, low toxicity and cell targeting remains challenging.
  TRIB3 at the interface of metabolism and inflammation in adipose tissue
  Dr H Wilson, Prof E Kiss-Toth
Applications accepted all year round

Funding Type

PhD Type

Obesity drives chronic inflammation and immune activation. This results in dysregulated metabolism, insulin resistance linked to diabetes, cardiovascular disease and cancer.
  Application of data science to inherited genetic variants of apoptosis genes and susceptibility to breast cancer
  Prof A Cox, Dr K Walters
Applications accepted all year round

Funding Type

PhD Type

Background. The identification of the breast and ovarian cancer genes BRCA1 and BRCA2 two decades ago has resulted in both improved patient risk assessment and the use of PARP-inhibitors for treatment.
  Novel bone-targeted therapy for multiple myeloma
  Dr M Lawson, Dr A Chantry
Applications accepted all year round

Funding Type

PhD Type

Myeloma remains an incurable cancer despite improvements in survival outcomes over the last few years, due to the development of better therapies.
  Bacterial-derived magnetosomes as nanocarriers for cancer-killing oncolytic viruses.
  Dr M Muthana, Dr F Howard
Applications accepted all year round

Funding Type

PhD Type

Dysfunctional cellular processes that are the markers of neoplasms provide the ideal environment for viral infection including sustained proliferation and resistance to cell death.
  Evaluation of ex vivo screening methodology
  Dr S Danson, Prof T Helleday
Applications accepted all year round

Funding Type

PhD Type

Cancer affects over 14M individuals worldwide each year and in the UK only 50% of patients have a 10 year survival following cancer diagnosis.
  Exploring the role of OGG1 in fibroblast senescence
  Dr D Lambert, Prof T Helleday
Applications accepted all year round

Funding Type

PhD Type

Fibroblasts are the major cell type of connective tissue. They play a critical role in maintaining the extracellular matrix, the ‘glue’ in which most cells reside, and maintaining normal function of other types of cells such as epithelial and immune cells.
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