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Cancer / Oncology PhD Projects, Programs & Scholarships in Sheffield

We have 31 Cancer / Oncology PhD Projects, Programs & Scholarships in Sheffield

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  Characterisation of the role of the adhesion protein tensin 3 in breast cancer progression
  Dr E Rainero
Applications accepted all year round

Funding Type

PhD Type

Breast cancer arises from the transformation of mammary epithelial cells. In the healthy tissue, these grow as a single monolayer of cells delimiting an internal hollow lumen 2.
  Investigating the role of the protease ADAMTS5 in ovarian cancer
  Dr E Rainero
Applications accepted all year round

Funding Type

PhD Type

Ovarian cancer is the most lethal gynaecological malignancy. Mostly because of late stage diagnosis, the 5-year survival rate is.
  MRC DiMeN Doctoral Training Partnership: From Live Cells to Single-molecules: Unravelling the interplay between 3D genomic structure and gene expression
  Dr C Toseland, Dr T Craggs
Application Deadline: 6 January 2020

Funding Type

PhD Type

This studentship is focused on applying state-of-the-art single molecule imaging techniques to study the molecular basis of DNA condensation and its impact upon gene expression.
  MRC DiMeN Doctoral Training Partnership: Activation of Aurora Kinase A by DNA damage – understanding the signalling pathway to improve radiotherapy response
  Dr H Bryant, Prof C Eyers, Prof P Eyers
Application Deadline: 6 January 2020

Funding Type

PhD Type

Radiation is a mainstay of cancer therapy, however radioresistance is a significant challenge in the treatment of locally advanced, recurrent and metastatic cancers.
  How do antibiotics kill bacteria?
  Prof S J Foster
Applications accepted all year round

Funding Type

PhD Type

Despite being a lynchpin of modern healthcare we still do not understand how cell wall active antibiotics such as penicillin and vancomycin kill growing bacteria, although several theories have been proposed.
  The regulation of Staphylococcus aureus cell division
  Prof S J Foster
Applications accepted all year round

Funding Type

PhD Type

Staphylococcus aureus is a major human pathogen causing significant death and disease around the world. The problem is exacerbated by the spread of antibiotic resistant strains.
  The role of protein turnover in bacterial life and death
  Prof S J Foster
Applications accepted all year round

Funding Type

PhD Type

The control of protein levels in bacterial cells is essential for their growth and survival. This is an interplay between protein synthesis and turnover.
  MRC DiMeN Doctoral Training Partnership: DUB-ing chronic inflammation: a drug repurposing approach to target deubiquitinases in inflammatory disease
  Dr H Ismail, Prof S Renshaw, Dr L Guo
Application Deadline: 6 January 2020

Funding Type

PhD Type

Background. Inflammation is an essential defence mechanism adapted by our bodies to eliminate damaged cells, irritants and pathogens.
  MRC DiMeN Doctoral Training Partnership: Understanding the role of DRAM in infection and autophagy-related disease
  Dr J King, Dr P Elks
Application Deadline: 6 January 2020

Funding Type

PhD Type

Intracellular degradation by lysosomes is important in a wide range of diseases. The capture and degradation of cytoplasmic components by autophagy allows tumour cells to survive starvation and neurons to remove the protein aggregates associated with neurodegeneration.
  MRC DiMeN Doctoral Training Partnership: Targeting ageing mitochondrial metabolism with dietary interventions to combat colorectal cancer
  Dr M J P Simons, Dr K Campbell, Dr L Greaves
Application Deadline: 6 January 2020

Funding Type

PhD Type

Background. Colorectal cancer is the second most common cause of death by cancer in the UK. Diet in particular, impacts on colorectal cancer development.
  Mechanistic Study of Molecular Assembly for Drug and Gene Delivery
  Dr X Zhao
Applications accepted all year round

Funding Type

PhD Type

Despite numerous advances over the past several decades, effective drug and gene delivery with high efficiency, low toxicity and cell targeting remains challenging.
  TRIB3 at the interface of metabolism and inflammation in adipose tissue
  Dr H Wilson, Prof E Kiss-Toth
Applications accepted all year round

Funding Type

PhD Type

Obesity drives chronic inflammation and immune activation. This results in dysregulated metabolism, insulin resistance linked to diabetes, cardiovascular disease and cancer.
  Application of data science to inherited genetic variants of apoptosis genes and susceptibility to breast cancer
  Prof A Cox, Dr K Walters
Applications accepted all year round

Funding Type

PhD Type

Background. The identification of the breast and ovarian cancer genes BRCA1 and BRCA2 two decades ago has resulted in both improved patient risk assessment and the use of PARP-inhibitors for treatment.
  Novel bone-targeted therapy for multiple myeloma
  Dr M Lawson, Dr A Chantry
Applications accepted all year round

Funding Type

PhD Type

Myeloma remains an incurable cancer despite improvements in survival outcomes over the last few years, due to the development of better therapies.
  Bacterial-derived magnetosomes as nanocarriers for cancer-killing oncolytic viruses.
  Dr M Muthana, Dr F Howard
Applications accepted all year round

Funding Type

PhD Type

Dysfunctional cellular processes that are the markers of neoplasms provide the ideal environment for viral infection including sustained proliferation and resistance to cell death.
  Evaluation of ex vivo screening methodology
  Dr S Danson, Prof T Helleday
Applications accepted all year round

Funding Type

PhD Type

Cancer affects over 14M individuals worldwide each year and in the UK only 50% of patients have a 10 year survival following cancer diagnosis.
  Exploring the role of OGG1 in fibroblast senescence
  Dr D Lambert, Prof T Helleday
Applications accepted all year round

Funding Type

PhD Type

Fibroblasts are the major cell type of connective tissue. They play a critical role in maintaining the extracellular matrix, the ‘glue’ in which most cells reside, and maintaining normal function of other types of cells such as epithelial and immune cells.
  Characterisation of in vitro models of human salivary glands and their use in functional studies
  Dr L Bingle, Prof C Bingle
Applications accepted all year round

Funding Type

PhD Type

Saliva is produced by three pairs of major salivary glands and multiple minor glands in the lips, associated with the tongue and also with the palate.
  The oral microbiome, ROS and the development of oral cancer: a role in Fanconi anemia?
  Prof K Hunter, Dr S Collis
Applications accepted all year round

Funding Type

PhD Type

Many patients with Fanconi Anemia (FA) develop cancers of the mouth, esophagus or anogential region. A number of reasons have been suggested, but the millions of bacteria that are naturally resident in these body sites might be a significant contributory factor.
  Modelling the epigenome in oral dysplasia and early invasive carcinoma
  Prof K Hunter, Dr H Colley
Applications accepted all year round

Funding Type

PhD Type

The key molecular events which lead to the development of premalignant oral lesions and their progression to oral cancer are still poorly understood.
  The Role of Fusion Genes Tumourigenesis
  Dr L Bingle, Prof C Bingle
Applications accepted all year round

Funding Type

PhD Type

Salivary gland tumours are uncommon but have a varied and complex pattern of histopathological features.
  Does fatty acid uptake by oral cancer cells drive metastasis?
  Dr C Murdoch, Dr H Colley
Applications accepted all year round

Funding Type

PhD Type

The cell surface receptor CD36 belongs to a large scavenger receptor family that primarily bind lipid-containing molecules. Until recently their expression was thought to be restricted to macrophages and endothelial cells but recent data suggest that epithelial cancer cells may also express this receptor.
  Patient experience of the Mesothelioma Stratified Therapy Trial (MiST): a qualitative study
  Prof A Tod, Dr B Taylor
Applications accepted all year round

Funding Type

PhD Type

This PhD provides a unique opportunity for a student to conduct a qualitative patient experience health services research study within a complex stratified clinical trial for people with malignant mesothelioma (MM), the Mesothelioma Stratified Therapy Trial (MiST).
  Factors influencing successful implementation of advanced nursing practice roles in oncology: a qualitative inquiry.
  Prof A Tod, Dr R King
Applications accepted all year round

Funding Type

PhD Type

This PhD provides a unique opportunity for a student to conduct an in-depth qualitative study exploring factors influencing the successful implementation of Advanced Nursing Practice (ANP) roles in an oncology setting.
  Evaluation of natural and novel tumour-selective cannabinoids in melanoma progression and metastases
  Dr A Idris, Dr S Danson
Application Deadline: 31 January 2020

Funding Type

PhD Type

The majority of deaths from melanoma following conventional therapies are a result of metastases.
  Mechanisms of cell membranes repair in health and disease
  Dr B Ciani
Applications accepted all year round

Funding Type

PhD Type

Compartmentalisation of chemical reactions and packaging of genetic material is fundamental for the healthy state of any biological cell.
  HDAC inhibitors: a potential therapy for breast cancer?
  Dr C Staton, Dr B Corfe
Applications accepted all year round

Funding Type

PhD Type

Radiation resistance, due to hypoxia, remains a major cause of mortality in the treatment of breast cancer.
  High-throughput mechanobiology
  Dr C Toseland
Applications accepted all year round

Funding Type

PhD Type

Cancer research has traditionally focused upon extra- or intra-cellular biochemical signals, and their relation to cancer development and metastasis.
  Actin regulation of nuclear mechanics during DNA repair
  Dr C Toseland
Applications accepted all year round

Funding Type

PhD Type

In eukaryotic cells, the nucleus houses the genomic material and transcription machinery that allows the cell to develop and perform its role.
  Treating cancer by targeting the mechanical properties of cells
  Dr A Gad
Applications accepted all year round

Funding Type

PhD Type

Cancer development is marked by massive increase of matrix fibres around tumor cells, which changes the mechanical properties of the tissue and is used to diagnose tumours by manual palpation.
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