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Cell Biology / Development PhD Projects, Programs & Scholarships in Sheffield

We have 39 Cell Biology / Development PhD Projects, Programs & Scholarships in Sheffield

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Showing 1 to 15 of 39
  Differential Regulation of mRNA isoform Expression in Metastatic Cancer
  Dr W English, Dr M Dunning
Applications accepted all year round

Funding Type

PhD Type

Metastasis is the principle cause of mortality in patients with cancer. An increased understanding of the molecular drivers that lead to primary, localised cancer becoming metastatic disease could provide new opportunities for therapy.
  The role of Sonic hedgehog in embryonic cell proliferation
  Prof M Placzek, Dr M Towers
Applications accepted all year round

Funding Type

PhD Type

This project aims to investigate how Sonic hedgehog (Shh) signalling controls embryonic cell proliferation.
  Addressing the functional significance of distinct paths to catalytic sites within the exosome
  Dr P Mitchell
Applications accepted all year round

Funding Type

PhD Type

The exosome RNase complex contains two associated catalytic subunits, one of which has two distinct catalytic sites (Mitchell, 2014).
  Analysis of the exoribonuclease Rex1
  Dr P Mitchell
Applications accepted all year round

Funding Type

PhD Type

Inhibition of one exosome catalytic subunit renders cells dependent upon another RNase called Rex1.
  Dissecting the mechanisms of antibiotic resistance in Clostridium difficile
  Dr R Fagan
Applications accepted all year round

Funding Type

PhD Type

Antibiotic resistance in pathogenic bacteria is one of the greatest health challenges facing humanity today.
  Optimisation of gene expression routes for heterologous protein expression in CHO cells
  Dr P Mitchell
Applications accepted all year round

Funding Type

PhD Type

CHO cells are commonly used as a vehicle for the production of heterologous proteins in the biopharmaceutical industry. We are currently using gene knock down and knock in approaches to increase the expression level of target recombinant proteins for potential use in industrial scale applications.
  Interleukin-36 and Its Receptor
  Dr M Nicklin
Applications accepted all year round

Funding Type

PhD Type

I am exploring how the pro-inflammatory cytokine interleukin-36 can become activated and the structural features of the receptor and the cytokine that allow activation to be recognised in vivo.
  Can neutrophil microvesicles influence the phenotype of monocytes - linking systemic inflammation with heart disease
  Dr V Ridger, Prof E Kiss-Toth
Applications accepted all year round

Funding Type

PhD Type

Cardiovascular disease (CVD) remains the leading cause of death worldwide. Atherosclerosis, the build up of fibro-fatty plaques in the wall of arteries, is the underlying cause of the heart attack and stroke.
  Role of primary cilia in skeletal muscle stem cells and muscle regeneration.
  Dr A G Borycki
Applications accepted all year round

Funding Type

PhD Type

Primary cilia are ancient organelles present at the surface of many cell types in vertebrates. In recent years, they have been shown to play essential roles in relaying sensory and signalling information from the environment to the cell.
  Regulation of cell cycle progression in skeletal muscle stem cells
  Dr A G Borycki
Applications accepted all year round

Funding Type

PhD Type

The ability of skeletal muscles to regenerate in response to injury, exercise, growth or disease depends on a population of adult skeletal muscle stem cells called satellite cells.
  Structural and functional characterisation of a novel cyanobacterial nanocompartment
  Dr E Hoiczyk
Applications accepted all year round

Funding Type

PhD Type

Increasing efficiency is an important driving force behind cellular organization and often achieved through compartmentalization.
  Investigating the mechanobiological mechanisms of cancer
  Dr K Erdmann
Applications accepted all year round

Funding Type

PhD Type

Cancer is the second-leading cause for death globally and there is a high demand for novel approaches to understand and treat cancer.
  Watching cancer metastasise live and investigating the underlying mechanisms
  Dr K Campbell, Dr M J P Simons
Applications accepted all year round

Funding Type

PhD Type

Cancer metastasis accounts for around 90% of cancer deaths. While the survival rate has been improved over the years through early diagnosis, limited progress has been made in the targeting of metastasis.
  Analysis of the role of Hypoxia Inducibe Factor pathway in radioprotection
  Dr F Van Eeden
Applications accepted all year round

Funding Type

PhD Type

Hypoxia inducible factor (HIF) is highly important in human health and disease, as is testified by the 2019 Nobel prize for Medicine or Physiology.
  Novel therapeutic approaches for the treatment of Duchenne muscular dystrophy.
  Prof S Winder
Applications accepted all year round

Funding Type

PhD Type

Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene leading to loss of the cytoskeletal protein dystrophin.
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