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Cell Biology / Development PhD Projects, Programs & Scholarships in Sheffield

We have 37 Cell Biology / Development PhD Projects, Programs & Scholarships in Sheffield

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Showing 21 to 30 of 37
  Homeostatic balancing of neuronal excitation and inhibition in vivo
  Dr A Lin
Applications accepted all year round

Funding Type

PhD Type

Neuronal excitation and inhibition are very carefully balanced in the brain, and perturbed excitation/inhibition (E/I) balance has been linked to diseases such as epilepsy, autism and schizophrenia.
  Imaging neurotransmitter release to measure synaptic plasticity underlying associative memory
  Dr A Lin
Applications accepted all year round

Funding Type

PhD Type

How does the brain encode memories? We think learning occurs by changes in the strength of synaptic connections between neurons, but the precise mechanisms by which this synaptic plasticity occurs is often unknown.
  Identifying new drugs to combat the virulence mechanisms underlying multidrug-resistant typhoid.
  Dr D Humphreys
Applications accepted all year round

Funding Type

PhD Type

Multidrug-resistant typhoid. --------------------------------------------. The world is facing an epidemic of multidrug-resistant (MDR) typhoid fever.
  Investigating the role of the mechanosensor channel Piezo1 in human disease
  Dr K Erdmann
Applications accepted all year round

Funding Type

PhD Type

Piezo proteins are ion channels that are gated by mechanical stimuli like stretch or shear stress. In mammalians there are two Piezo isoforms (Piezo1 and Piezo2) with largely different expression pattern.
  Investigating the molecular mechanism of inflammatory bowel disease
  Dr K Erdmann
Applications accepted all year round

Funding Type

PhD Type

Cohn’s disease together with ulcerative colitis (UC) are the two main variations of inflammatory bowel disease (IBD). 2.5-3 million people in Europe are affected by inflammatory bowel disease with a direct healthcare cost of 4.5-6 billion Euro per year.
  Molecular dissection of protein palmitoylation in neurons
  Dr M Collins
Applications accepted all year round

Funding Type

PhD Type

Palmitoylation (S-acylation), the only known reversible lipid modification of proteins, is an important regulator of protein localisation and function.
  Molecular dissection of activity-dependent neuronal signalling pathways using quantitative proteomics
  Dr M Collins
Applications accepted all year round

Funding Type

PhD Type

Recent proteomic investigations have identified several thousand proteins in biochemically purified synapses and have uncovered multiprotein complexes essential for synapse function.
  Cell plasticity in development and disease
  Dr K Campbell
Applications accepted all year round

Funding Type

PhD Type

Although 90% of cancer deaths are caused by metastasis, the underlying pathogenic mechanisms are poorly understood.
  Non-coding RNA regulation of stem cells
  Dr S Brown, Dr P Gokhale
Applications accepted all year round

Funding Type

PhD Type

Stem cells have the potential to make any cell type in the Human body and are powerful tools in drug discovery (Xia and Wong, 2012).
  Engineering the skeletal muscle stem cell niche using microporous tissue engineering constructs
  Dr A G Borycki
Applications accepted all year round

Funding Type

PhD Type

Background. Satellite cells are skeletal muscle stem cells that reside in a specific micro-environment called the niche and are responsible for muscle repair upon injury or diseases.
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