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Cell Biology / Development PhD Projects, Programs & Scholarships in Sheffield

We have 37 Cell Biology / Development PhD Projects, Programs & Scholarships in Sheffield

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  Understanding and targeting dysregulated calcium signaling in neurodegeneration
  Dr K de Vos, Dr E Seward
Application Deadline: 2 August 2019

Funding Type

PhD Type

Applications are being invited for a 3.5-year Basic Neuroscience PhD Studentship, starting in October 2019.
  modelling skeletal dysplasias in zebrafish.
  Dr H Roehl, Dr M Balasubramanian
Applications accepted all year round

Funding Type

PhD Type

Whole genome sequencing studies have led to a vast amount of new candidate genes for human diseases.
  PhD in evolutionary biology - examining the evolution of interactions between species
  Prof R Freckleton
Applications accepted all year round

Funding Type

PhD Type

Evolutionary biology is underpinned by models for the evolution of species and their traits. The growing body of phylogenetic information, as well as increases in computational power allows us to develop and test novel models and theories of evolution.
  High-throughput mechanobiology
  Dr C Toseland
Applications accepted all year round

Funding Type

PhD Type

Cancer research has traditionally focused upon extra- or intra-cellular biochemical signals, and their relation to cancer development and metastasis.
  Actin regulation of nuclear mechanics during DNA repair
  Dr C Toseland
Applications accepted all year round

Funding Type

PhD Type

In eukaryotic cells, the nucleus houses the genomic material and transcription machinery that allows the cell to develop and perform its role.
  Identification of the molecular pathways that guide zebrafish regeneration.
  Dr H Roehl
Applications accepted all year round

Funding Type

PhD Type

The study of regenerative biology aims to elucidate the innate ability of organisms to replace tissues or organs after they have been removed or damaged.
  Treating cancer by targeting the mechanical properties of cells
  Dr A Gad
Applications accepted all year round

Funding Type

PhD Type

Cancer development is marked by massive increase of matrix fibres around tumor cells, which changes the mechanical properties of the tissue and is used to diagnose tumours by manual palpation.
  Role of Hedgehog signalling in skeletal muscle regeneration
  Dr A G Borycki
Applications accepted all year round

Funding Type

PhD Type

The ability of skeletal muscle to regenerate in response to injury, exercise, growth or disease depends on a population of stem cells called satellite cells.
  Mechanisms of microtubule organization by cell-cell adhesion in epithelial cells.
  Dr N Bulgakova
Applications accepted all year round

Funding Type

PhD Type

The correct organization of the microtubule cytoskeleton is critical for the survival and normal function of cells in a multicellular organism.
  Addressing the functional significance of distinct paths to catalytic sites within the exosome
  Dr P Mitchell
Applications accepted all year round

Funding Type

PhD Type

The exosome RNase complex contains two associated catalytic subunits, one of which has two distinct catalytic sites (Mitchell, 2014).
  Analysis of the exoribonuclease Rex1
  Dr P Mitchell
Applications accepted all year round

Funding Type

PhD Type

Inhibition of one exosome catalytic subunit renders cells dependent upon another RNase called Rex1.
  Dissecting the mechanisms of antibiotic resistance in Clostridium difficile
  Dr R Fagan
Applications accepted all year round

Funding Type

PhD Type

Antibiotic resistance in pathogenic bacteria is one of the greatest health challenges facing humanity today.
  Optimisation of gene expression routes for heterologous protein expression in CHO cells
  Dr P Mitchell
Applications accepted all year round

Funding Type

PhD Type

CHO cells are commonly used as a vehicle for the production of heterologous proteins in the biopharmaceutical industry. We are currently using gene knock down and knock in approaches to increase the expression level of target recombinant proteins for potential use in industrial scale applications.
  Self-association of the Alzheimer’s peptide Aβ on membrane surfaces
  Prof M P Williamson
Applications accepted all year round

Funding Type

PhD Type

Alzheimer’s disease is a neurodegenerative disease that is particularly common amongst the elderly. It accounts for about 65% of all cases of dementia, and affects about 6% of people over 65, rising to 50% of people over 85.
  Tetraspanin structure and function
  Dr L J Partridge
Applications accepted all year round

Funding Type

PhD Type

The tetraspanins are a diverse, conserved family of eukaryotic membrane proteins. Their principal feature is the ability to form dynamic multi-molecular assemblies in cell membranes known as tetraspanin enriched microdomains (TEM).
  Reactive Inkjet Printing of Tissue Culture Scaffolds
  Dr X Zhao
Applications accepted all year round

Funding Type

PhD Type

3D scaffolds with excellent biocompatibility, biodegradability, sophisticated 3D structures and appropriate mechanical properties are particularly desired as in vitro models in biomedical research and are highly attractive in clinical applications (e.g.
  Novel therapeutic approaches for the treatment of Duchenne muscular dystrophy
  Prof S Winder
Applications accepted all year round

Funding Type

PhD Type

Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene leading to loss of the cytoskeletal protein dystrophin.
  Defining the dynamics of lineage segregations during human neuromesodermal axial progenitor differentiation
  Dr A Tsakiridis, Dr A Fletcher
Applications accepted all year round

Funding Type

PhD Type

Embryonic axis elongation is the process that gives rise to all cell types making up the body trunk.
  Developing a therapy for hearing loss using human pluripotent stem cells
  Prof M Rivolta
Applications accepted all year round

Funding Type

PhD Type

The vast majority of cases of deafness are produced by the irreversible loss of the sensory hair cells and their associated neurons.
  Elucidating the molecular function of SNAP29 a gene mutated in CEDNIK syndrome
  Dr A Peden
Applications accepted all year round

Funding Type

PhD Type

CEDNIK (cerebral dysgenesis, neuropathy, ichthyosis and keratoderma) syndrome is a rare fatal disease caused by the loss of SNAP29.
  Homeostatic balancing of neuronal excitation and inhibition in vivo
  Dr A Lin
Applications accepted all year round

Funding Type

PhD Type

Neuronal excitation and inhibition are very carefully balanced in the brain, and perturbed excitation/inhibition (E/I) balance has been linked to diseases such as epilepsy, autism and schizophrenia.
  Imaging neurotransmitter release to measure synaptic plasticity underlying associative memory
  Dr A Lin
Applications accepted all year round

Funding Type

PhD Type

How does the brain encode memories? We think learning occurs by changes in the strength of synaptic connections between neurons, but the precise mechanisms by which this synaptic plasticity occurs is often unknown.
  Identifying new drugs to combat the virulence mechanisms underlying multidrug-resistant typhoid.
  Dr D Humphreys
Applications accepted all year round

Funding Type

PhD Type

Multidrug-resistant typhoid. --------------------------------------------. The world is facing an epidemic of multidrug-resistant (MDR) typhoid fever.
  Investigating the role of the mechanosensor channel Piezo1 in human disease
  Dr K Erdmann
Applications accepted all year round

Funding Type

PhD Type

Piezo proteins are ion channels that are gated by mechanical stimuli like stretch or shear stress. In mammalians there are two Piezo isoforms (Piezo1 and Piezo2) with largely different expression pattern.
  Investigating the molecular mechanism of inflammatory bowel disease
  Dr K Erdmann
Applications accepted all year round

Funding Type

PhD Type

Cohn’s disease together with ulcerative colitis (UC) are the two main variations of inflammatory bowel disease (IBD). 2.5-3 million people in Europe are affected by inflammatory bowel disease with a direct healthcare cost of 4.5-6 billion Euro per year.
  Molecular dissection of protein palmitoylation in neurons
  Dr M Collins
Applications accepted all year round

Funding Type

PhD Type

Palmitoylation (S-acylation), the only known reversible lipid modification of proteins, is an important regulator of protein localisation and function.
  Molecular dissection of activity-dependent neuronal signalling pathways using quantitative proteomics
  Dr M Collins
Applications accepted all year round

Funding Type

PhD Type

Recent proteomic investigations have identified several thousand proteins in biochemically purified synapses and have uncovered multiprotein complexes essential for synapse function.
  Cell plasticity in development and disease
  Dr K Campbell
Applications accepted all year round

Funding Type

PhD Type

Although 90% of cancer deaths are caused by metastasis, the underlying pathogenic mechanisms are poorly understood.
  Non-coding RNA regulation of stem cells
  Dr S Brown, Dr P Gokhale
Applications accepted all year round

Funding Type

PhD Type

Stem cells have the potential to make any cell type in the Human body and are powerful tools in drug discovery (Xia and Wong, 2012).
  Engineering the skeletal muscle stem cell niche using microporous tissue engineering constructs
  Dr A G Borycki
Applications accepted all year round

Funding Type

PhD Type

Background. Satellite cells are skeletal muscle stem cells that reside in a specific micro-environment called the niche and are responsible for muscle repair upon injury or diseases.
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