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Genetics PhD Projects, Programs & Scholarships in Sheffield

We have 9 Genetics PhD Projects, Programs & Scholarships in Sheffield

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Showing 1 to 9 of 9
  Elucidating the molecular function of SNAP29 a gene mutated in CEDNIK syndrome
  Dr A Peden
Applications accepted all year round
CEDNIK (cerebral dysgenesis, neuropathy, ichthyosis and keratoderma) syndrome is a rare fatal disease caused by the loss of SNAP29.
  Homeostatic balancing of neuronal excitation and inhibition in vivo
  Dr A Lin
Applications accepted all year round
Neuronal excitation and inhibition are very carefully balanced in the brain, and perturbed excitation/inhibition (E/I) balance has been linked to diseases such as epilepsy, autism and schizophrenia.
  Imaging neurotransmitter release to measure synaptic plasticity underlying associative memory
  Dr A Lin
Applications accepted all year round
How does the brain encode memories? We think learning occurs by changes in the strength of synaptic connections between neurons, but the precise mechanisms by which this synaptic plasticity occurs is often unknown.
  Deciphering Roles of SUMOylation in mini-Human Brains in Health and Disease
  Dr C Guo, Dr S Brown
Applications accepted all year round
Neurodegenerative disorders and cerebral ischemia are incurable conditions, imposing tough medical challenges and a substantial economic burden on health services.
  Investigating the molecular mechanism of inflammatory bowel disease
  Dr K Erdmann
Applications accepted all year round
Cohn’s disease together with ulcerative colitis (UC) are the two main variations of inflammatory bowel disease (IBD). 2.5-3 million people in Europe are affected by inflammatory bowel disease with a direct healthcare cost of 4.5-6 billion Euro per year.
  Non-coding RNA regulation of stem cells
  Dr S Brown, Dr P Gokhale
Applications accepted all year round
Stem cells have the potential to make any cell type in the Human body and are powerful tools in drug discovery (Xia and Wong, 2012).
  Unravelling how mechanical forces build breast tissue to help tackle cancer
  Dr N Akhtar, Dr A Fletcher
Application Deadline: 28 February 2019
Project description. Disrupted tissue architecture is a central hallmark of cancer. For example, breast cancer is characterized by an abnormal growth of cells filling the hollow spaces of the tissue.
  Diet and mTor signaling in ageing-related neurodegenerative disease
  Dr M J P Simons, Dr S Sweeney
Applications accepted all year round
Reducing food intake robustly increases lifespan in model organisms. When this data is extrapolated to humans, the predicted gain in healthy lifespan beats curing all stroke, diabetes, cancer and cardiac disease.
  Characterisation of bacterial effectors delivered by the type VI secretion system
  Dr M Thomas
Applications accepted all year round
Many bacterial virulence determinants are secreted proteins referred to as ’effectors’ that benefit the pathogen by allowing it to subvert, damage or kill the host.
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