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Immunology PhD Projects, Programs & Scholarships in Sheffield

We have 19 Immunology PhD Projects, Programs & Scholarships in Sheffield

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Showing 1 to 15 of 19
  Investigating the control and function of macrophage subtypes using Drosophila melanogaster
  Dr I Evans
Applications accepted all year round

Funding Type

PhD Type

The phagocytic white blood cells known as macrophages are a highly heterogeneous population of cells. This heterogeneity stems from their differentiation from monocytes, the presence of tissue resident cells and their ability to polarise to a wide range of activation states.
  Identifying novel regulators of haematopoiesis using flies
  Dr I Evans, Dr S Brown
Applications accepted all year round

Funding Type

PhD Type

Control of blood cell proliferation, survival and activation is critical to the health of an organism. Defects in this control can lead to a wide range of diseases or pathological conditions including cancer, immunodeficiencies or autoimmunity.
  Meals for macrophages – investigating how macrophages engulf and process dying cells in vivo
  Dr I Evans, Dr P Elks, Dr S Johnston
Applications accepted all year round

Funding Type

PhD Type

A critical role for phagocytic cells such as macrophages is the engulfment and subsequent degradation of dying cells and debris. Failure to clear targets such as apoptotic cells can lead to damaging autoimmune conditions and immune cell dysfunction (Morioka et al., 2019; Roddie et al., 2019).
  Analysis of the exoribonuclease Rex1
  Dr P Mitchell
Applications accepted all year round

Funding Type

PhD Type

Inhibition of one exosome catalytic subunit renders cells dependent upon another RNase called Rex1.
  Investigating the molecular basis of this adhesion and the development of tetraspanin-based reagents for preventing bacterial infections
  Dr L J Partridge
Applications accepted all year round

Funding Type

PhD Type

The tetraspanins are a diverse, conserved family of eukaryotic membrane proteins. Their principal feature is the ability to form dynamic multi-molecular assemblies in cell membranes known as tetraspanin enriched microdomains (TEM).
  Tetraspanin structure and function
  Dr L J Partridge
Applications accepted all year round

Funding Type

PhD Type

The tetraspanins are a diverse, conserved family of eukaryotic membrane proteins. Their principal feature is the ability to form dynamic multi-molecular assemblies in cell membranes known as tetraspanin enriched microdomains (TEM).
  Interleukin-36 and Its Receptor
  Dr M Nicklin
Applications accepted all year round

Funding Type

PhD Type

I am exploring how the pro-inflammatory cytokine interleukin-36 can become activated and the structural features of the receptor and the cytokine that allow activation to be recognised in vivo.
  Can neutrophil microvesicles influence the phenotype of monocytes - linking systemic inflammation with heart disease
  Dr V Ridger, Prof E Kiss-Toth
Applications accepted all year round

Funding Type

PhD Type

Cardiovascular disease (CVD) remains the leading cause of death worldwide. Atherosclerosis, the build up of fibro-fatty plaques in the wall of arteries, is the underlying cause of the heart attack and stroke.
  Endothelial senescence and healthy ageing
  Prof S Francis, Prof I Bellantuono
Applications accepted all year round

Funding Type

PhD Type

Endothelial senescence is a key biological mechanism in the development of coronary artery disease and ageing.
  Structural and functional characterisation of a novel cyanobacterial nanocompartment
  Dr E Hoiczyk
Applications accepted all year round

Funding Type

PhD Type

Increasing efficiency is an important driving force behind cellular organization and often achieved through compartmentalization.
  Targeting pathogen subversion of cellular ageing to combat antimicrobial-resistant typhoid fever
  Dr D Humphreys, Dr T Darton
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial-resistant typhoid fever is fuelled by chronic Salmonella carriage. The world faces epidemics of untreatable typhoid fever caused by antimicrobial-resistant strains of Salmonella Typhi (~27 million cases/year).
  Understanding the role of DRAM in infection and autophagy-related disease
  Dr J King, Dr P Elks
Applications accepted all year round

Funding Type

PhD Type

Intracellular degradation by lysosomes is important in a wide range of diseases. The capture and degradation of cytoplasmic components by autophagy allows tumour cells to survive starvation and neurons to remove the protein aggregates associated with neurodegeneration.
  Combined targeting of PD-L1 and NFκB pathways to reverse T-cell exhaustion and restore anti-tumour immunity in breast cancer.
  Dr A Idris
Application Deadline: 1 July 2020

Funding Type

PhD Type

The majority of deaths from breast cancer following conventional therapies are a result of metastases. Programmed death 1 ligand (PD-L1), a negative regulator of the immune system, is highly expressed in triple negative breast tumours and cell lines, and its expression is associated with suppressed anti-tumour immunity.
  Targeting perivascular macrophages to enhance the efficacy of immunotherapy in prostate cancer
  Prof CE Lewis, Dr M Muthana
Applications accepted all year round

Funding Type

PhD Type

Immunotherapies like checkpoint inhibitors do not work well in most prostate cancer patients, with only a small group showing durable responses.
  Project title: Elucidating the mechanisms of pathology in neurodevelopmental white matter diseases
  Dr N Hamilton
Applications accepted all year round

Funding Type

PhD Type

Our research interest is to dissect the mechanism of auto-inflammatory neurological disorders using zebrafish as an animal model.
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