Back pain is a major cause of morbidity worldwide and the incidence and severity of back pain increases with age. Approximately 40% of all back pain cases are caused by disease in the joints in the spine, known as the intervertebral discs.
Cohn’s disease together with ulcerative colitis (UC) are the two main variations of inflammatory bowel disease (IBD). 2.5-3 million people in Europe are affected by inflammatory bowel disease with a direct healthcare cost of 4.5-6 billion Euro per year.
Plasma cells are the antibody secreting cells of the immune system thus are vital for fighting infection. However, dysregulation of plasma cell function is linked to a broad range of disease from Lupus to multiple myeloma.