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We have 12 Pharmaceutical Chemistry PhD Projects, Programmes & Scholarships in Sheffield

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Chemistry

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Sheffield  United Kingdom

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Pharmaceutical Chemistry PhD Projects, Programmes & Scholarships in Sheffield

We have 12 Pharmaceutical Chemistry PhD Projects, Programmes & Scholarships in Sheffield

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Magnetic Nano-particles for the separation and purification of proteins

When proteins are synthesised (using a natural or cell-based method), they are contaminated with hundreds of other proteins, nucleic acids and numerous other small molecules. Read more
 Supervisor: Dr L Twyman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
More details

Magnetic Nano-particles for the separation and purification of proteins

When proteins are synthesised (using a natural or cell-based method), they are contaminated with hundreds of other proteins, nucleic acids and numerous… Read more
 Supervisor: Dr L Twyman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
More details

Synthesis of Peptidomimetics Based on Functionalizable Freidinger Lactams

Despite mediating a plethora of vital biological processes in living organisms, peptides remain a challenging class of drug targets due to their poor cell penetration, proteolytic instability and unfavourable pharmacokinetics. Read more
 Supervisor: Prof JPA Harrity
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
More details

Synthesis of Heteroaromatic Boronic Esters via Annulation Reactions of Ynone Trifluoroborate Salts

About the Project. We have recently shown that ynones armed with the synthetically versatile trifluoroborate functional group can be elaborated to a range of useful heteroaromatic building blocks (Ref 1) and that these offer useful platforms for drug discovery (Ref 2). Read more
 Supervisor: Prof JPA Harrity
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
More details

Synthesis of Artificial blood

Inspired by Nature, we have developed a number of porphyrin containing biomimetic macromolecules. These have included a porphyrin cored polymer capable of reversibly binding oxygen. As such, these molecules have the potential to be applied as a plastic or artificial blood product. Read more
 Supervisor: Dr L Twyman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
More details

New macro-ligands for protein binding, and drug delivery

Proteins bind and recognise each other using large surface areas. This recognition process is vital for a variety of biological applications. Read more
 Supervisor: Dr L Twyman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
More details

Dendrimers for Drug delivery

We have worked with a number of water soluble polymer systems capable of encapsulating and solubilising various hydrophobic drug moieties. Despite the formation of stable complexes, we have demonstrated that encapsulated drug can also be released. Read more
 Supervisor: Dr L Twyman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
More details

Dendrimers for Drug delivery

We have worked with a number of water soluble polymer systems capable of encapsulating and solubilising various hydrophobic drug moieties. Read more
 Supervisor: Dr L Twyman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
More details

Synthesis of Artificial blood

Inspired by Nature, we have developed a number of porphyrin containing biomimetic macromolecules. These have included a porphyrin cored polymer capable of reversibly binding oxygen. Read more
 Supervisor: Dr L Twyman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
More details

New macro-ligands for protein binding, and drug delivery.

Proteins bind and recognise each other using large surface areas. This recognition process is vital for a variety of biological applications. Read more
 Supervisor: Dr L Twyman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
More details

Synthesis of Peptidomimetics Based on Functionalizable Freidinger Lactams

Despite mediating a plethora of vital biological processes in living organisms, peptides remain a challenging class of drug targets due to their poor cell penetration, proteolytic instability and unfavourable pharmacokinetics. Read more
 Supervisor: Prof JPA Harrity
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
More details

Synthesis of Heteroaromatic Boronic Esters via Annulation Reactions of Ynone Trifluoroborate Salts

We have recently shown that ynones armed with the synthetically versatile trifluoroborate functional group can be elaborated to a range of useful heteroaromatic building blocks (Ref 1) and that these offer useful platforms for drug discovery (Ref 2). Read more
 Supervisor: Prof JPA Harrity
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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