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University of Oxford, Sir William Dunn School of Pathology PhD Projects, Programmes & Scholarships

We have 16 University of Oxford, Sir William Dunn School of Pathology PhD Projects, Programmes & Scholarships

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Sir William Dunn School of Pathology  University of Oxford

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We have 16 University of Oxford, Sir William Dunn School of Pathology PhD Projects, Programmes & Scholarships

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Viral manipulation of host cell biology for assembly, secretion and immune evasion

This project will investigate mechanisms of assembly, secretion and immune subversion adopted by (+)RNA viruses, with a particular emphasis on Dengue/Zika from the flavivirus and SARS-CoV-2 from the coronavirus families. Read more
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Motor proteins: from structural biology to human disease

Dynein and kinesin are families of motor proteins that use ATP hydrolysis to transport cellular components and signalling molecules along the microtubule cytoskeleton. Read more
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Molecular mechanisms safe-guarding genome stability during mammalian cell division

Faithful cell division ensures the correct segregation of the genetic material over multiple generations. Failure of this process may result in cell death or trigger tumorigenesis. Read more
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Molecular mechanisms of influenza virus replication

Influenza viruses are important human and animal pathogens; they cause widespread clinical and veterinary disease and have a considerable economic impact. Read more
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Mechanisms of protein quality control in health and disease

Accumulation of misfolded proteins and aberrant protein aggregates are hallmarks of a wide range of pathologies such as neurodegenerative diseases and cancer. Read more
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Homologous recombination at human centromeres – friend or foe?

The centromere is a region of chromatin that serves as a platform for the kinetochore machinery assembly, hence is essential for accurate chromosome segregation during cell division. Read more
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Function of R-loops in health and disease

R-loops are unusual RNA/DNA structures, formed in all living organisms where they play crucial roles in regulating gene expression, DNA and histone modifications, generation of antibody diversity, DNA replication and genome stability. Read more
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Discovery and mechanism evaluation of synthetic lethality in cancers of mesenchyme

In order to circumvent evolutionary selection and resistance to environmental context and anti-cancer agents, novel approaches that result in synthetic (synergistic) cell lethality (dependencies) that are specific for the cancer cell are most likely to have translational impact. Read more
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Characterising antibiotic-induced collateral damage in the gut microbiome

Antibiotics help clear an ongoing infection, but they can also cause significant collateral damage. they select for drug-resistant strains and cause dysbiosis to the commensal gut microbiota. Read more

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