Engineered antibodies for improved immunotherapies against breast cancer
Prof M. Crispin, Dr I Tews
3 March 2019
Antibodies have emerged as a major drug class for the treatment of human cancers and inflammatory disorders. Many of the therapeutic antibodies rely on their immune recruitment properties, engaging the host’s immune cells to antagonise tumours or dampen autoimmune responses (e.g.
The role of FcgRIIb in Parkinson’s Disease
Prof J Teeling, Dr P Williamson
10 March 2019
People with Parkinson’s disease (PD) have aggregates of misfolded alpha-synuclein (aSN) in their brains which are believed to play a key role in the disease.
Ultrafast Imaging of Cell-Nanobubble Interactions for Bone Repair
Dr N Evans, Dr D Carugo
1 March 2019
Acoustic bubbles can be loaded with drugs and resonate when excited by ultrasound. This property allows us to research their use in medicine – for example, we think that ultrasound from outside the body can be used to stimulate bubbles to release drugs to the right cells at the right time.
Synthetic Organic Approaches for Covalent Inhibition of Protein-Protein
Dr S Thompson
Applications accepted all year round
We are looking for an enthusiastic and well-organized student with an interest in applying the full range of synthetic organic chemistry methods to design and construct conformationally well-defined molecules (foldamers) that covalently recognise key elements of protein surfaces.