Structural Biology (complex) PhD Projects, Programmes & Scholarships

Delivery and misdelivery of outer membrane proteins to the BAM complex using cryoEM

University of Leeds Faculty of Biological Sciences

The BAM complex folds membrane proteins into the outer membrane of Gram-negative bacteria, proteins whose functions are essential for bacterial viability, pathogenicity and virulence. Read more

Supervisors: Prof N A Ranson, Prof S E Radford

Year round applications PhD Research Project Self-Funded PhD Students Only

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Development of LA1011 for high affinity binding to Hsp90 for use towards healthy ageing in patients showing Alzheimer’s symptoms

University of Sussex School of Life Sciences

Research Group: Biochemistry

With 50 million global cases of Alzheimer’s disease (AD) and care costs of 1 trillion UK pounds (expected to triple by 2050), there is a pressing need to slow disease progression, sustain productive lives and reduce costs. Read more

Supervisor: Dr C Prodromou

5 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Structure and function of enzyme complexes involved in post-transcriptional gene regulation

University of Nottingham School of Pharmacy

Many proteins in human cells function as part of high molecular weight multi-subunit assemblies. The structure and function of such large molecular machines is often difficult to characterise due to their complexity, low abundance and structural dynamics. Read more

Supervisor: Dr G S Winkler

Year round applications PhD Research Project Self-Funded PhD Students Only

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Structural and functional characterisation of MALT1 ubiquitination to aid in the development of novel anti-cancer therapies

University of Leicester Molecular and Cell Biology

Nuclear factor-kappa B (NF-kB) is a family of transcription factors that play a crucial role in regulating various cellular processes; primarily related to immune responses, inflammation, and cell survival. Read more

Supervisor: Dr G Hall

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding control of genome folding by cohesin

University of Leicester Molecular and Cell Biology

Our basic goal is to understand how chromatin structure influences gene regulation. Chromatin is generally repressive in nature but its structure is manipulated by cells in a regulated way to determine which genes are potentially transcriptionally active and which genes remain repressed in a given cell type. Read more

Supervisors: Prof D Panne, Dr T Schalch

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Structural insights into genome control by cohesin

University of Leicester Molecular and Cell Biology

Our basic goal is to understand how chromatin structure influences gene regulation. Chromatin is generally repressive in nature but its structure is manipulated by cells in a regulated way to determine which genes are potentially transcriptionally active and which genes remain repressed in a given cell type. Read more

Supervisor: Prof D Panne

Year round applications PhD Research Project Self-Funded PhD Students Only

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Novel glycoprotease discovery and characterisation for enhanced detergent performance

Newcastle University BiSCoP CTP

In this exciting joint academia-industry project the student will exploit metagenomes and the huge untapped capacity of the human gut microbiota to breakdown glycoconjugates to discover novel protease enzymes that can potentially increase the performance and environmental sustainability of leading P&G automatic dishwashing brands. Read more

Supervisors: Dr E Lowe, Dr D Bolam, Dr AL Morales Garcia, Mrs K Bell-Rusiewicz

2 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Machine learning algorithms for ab initio-based paramagnetic NMR analysis

University of Bath Department of Chemistry

The University of Bath is inviting applications for the following PhD project under the supervision of Dr Elizaveta Suturina in the Department of Chemistry. Read more

Supervisor: Dr E A Suturina

28 April 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas

University of Leeds Faculty of Biological Sciences

V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas. Read more

Supervisor: Dr J Boyes

Year round applications PhD Research Project Self-Funded PhD Students Only

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Targeting Ras palmitoylation for the treatment of cancer

University of Dundee School of Medicine

Lay summary. Proteins can be thought of as molecular machines that carry out work within cells. Protein activity can be regulated through the reversible attachment of certain chemical groups to specific amino acids within proteins. Read more

Supervisor: Dr N Fraser

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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Modelling blood motion in deformable vessels

University of Dundee School of Science and Engineering

This project aims to introduce a novel approach in studying blood flow in deformable vessels by simultaneously considering both the fluid (blood) and the structure (vessel) through analytical and numerical approaches. Read more

Supervisors: Dr M Hayatdavoodi, Prof P Lin

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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Discovery of novel antibiotics through synthesis of lab-based (biochem/microbio) and computational microbiology (molecular dynamics/deep generative learning/AI)

University of Portsmouth School of Pharmacy and Biomedical Sciences

As stated by the World Health Organisation (WHO), antimicrobial resistance (AMR) is one of the greatest public health threats facing humanity. Read more

Supervisor: Dr R Draheim

Year round applications PhD Research Project Self-Funded PhD Students Only

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Better together: constructing tuneable fluorescent protein sensors for cellular imaging of protein-protein interactions

Cardiff University Cardiff School of Biosciences

Project Description. Protein-protein interactions (PPIs) commonly occur in biology with ~650,000 contributing to processes critical to human life. Read more

Supervisors: Prof D Jones, Dr PD Watson, Dr G Menzies, Dr R Clarkson

Year round applications PhD Research Project Self-Funded PhD Students Only

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Chromatin remodelling complexes in human brain development

King’s College London Faculty of Life Sciences & Medicine

Chromatin regulators are a group of proteins that control the way the rest of the genome is opened up and “read” by the cellular machinery, with fundamental roles in development and disease. Read more

Supervisors: Dr CD Dias, Dr JA Atherton

Year round applications PhD Research Project Self-Funded PhD Students Only

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Taking Light Induced Electron Paramagnetic Resonance In Cell for Biological Structural Determination

The University of Manchester Department of Chemistry

Studying the structure of proteins and other biological systems is an important step in understanding their function. Most structural studies are conducted in environments that are far away from native conditions, such as those found inside a cell. Read more

Supervisors: Dr A Bowen, Dr J Rowbotham, Dr I Riddell, Dr D Heyes

Year round applications PhD Research Project Competition Funded PhD Project (Students Worldwide)

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We have 39 Structural Biology (complex) PhD Projects, Programmes & Scholarships

Structural Biology (complex) PhD Projects, Programmes & Scholarships

We have 39 Structural Biology (complex) PhD Projects, Programmes & Scholarships

Delivery and misdelivery of outer membrane proteins to the BAM complex using cryoEM

Development of LA1011 for high affinity binding to Hsp90 for use towards healthy ageing in patients showing Alzheimer’s symptoms

Structure and function of enzyme complexes involved in post-transcriptional gene regulation

Structural and functional characterisation of MALT1 ubiquitination to aid in the development of novel anti-cancer therapies

Understanding control of genome folding by cohesin

Structural insights into genome control by cohesin

Novel glycoprotease discovery and characterisation for enhanced detergent performance

Machine learning algorithms for ab initio-based paramagnetic NMR analysis

Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas

Targeting Ras palmitoylation for the treatment of cancer

Modelling blood motion in deformable vessels

Discovery of novel antibiotics through synthesis of lab-based (biochem/microbio) and computational microbiology (molecular dynamics/deep generative learning/AI)

Better together: constructing tuneable fluorescent protein sensors for cellular imaging of protein-protein interactions

Chromatin remodelling complexes in human brain development

Taking Light Induced Electron Paramagnetic Resonance In Cell for Biological Structural Determination

We have 39 Structural Biology (complex) PhD Projects, Programmes & Scholarships

Structural Biology (complex) PhD Projects, Programmes & Scholarships

We have 39 Structural Biology (complex) PhD Projects, Programmes & Scholarships

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