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Structural Biology (heart) PhD Projects, Programmes & Scholarships

We have 19 Structural Biology (heart) PhD Projects, Programmes & Scholarships

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NIHR Leeds BRC: Force sensing mechanisms of haemostasis in heart failure and diabetes

University of Leeds Faculty of Medicine and Health
Since the original identification of the role of PIEZO1 in vascular integrity and endothelial cell biology by our group in Leeds in 2014, there have been many publications on the role of PIEZO1 in endothelial function and its role in processes such as atherosclerosis, hypertension, cell-cell junctions, vascular permeability and leukocyte diapedesis. Read more
 Supervisors: Dr R Ariens, Prof D J Beech, Dr E Levelt
 26 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Epigenetics of early human development: From molecular mechanisms to regenerative medicine

University of Leicester Molecular and Cell Biology
Ever wondered how nature maintains balance of gene expression between sex chromosomes? Well, the 46th chromosome of XX females, the second X, has to be switched off. Read more
 Supervisors: Dr Y Markaki, Dr T Schalch
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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(MRC DTP CASE) Prediction of substrate binding geometry and strength in promiscuous enzymes: computational chemistry applicable to the design of pharmaceuticals and agrochemicals

The University of Manchester Faculty of Biology, Medicine and Health
We are often taught about the power of enzymes to select particular substrates from the biological milieu and of their ability to perform highly selective reactions on those substrates. Read more
 Supervisors: Dr A Leach, Dr S De Visser, Dr C Trujillo
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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(MRC DTP CASE) An Integrative Structural Biology Platform for Drug Discovery

The University of Manchester Faculty of Biology, Medicine and Health
Solute carriers (SLCs) are the second largest class of membrane-embedded proteins with over 400 members organised into 66 families. Read more
 Supervisors: Dr A Politis, Dr CP Pliotas
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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The role of ubiquitin-modifying enzymes in angiogenesis

University of Leeds Faculty of Biological Sciences
The School of Molecular & Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more
 Supervisors: Dr S Ponnambalam, Dr M A Harrison
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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New enzymatic routes for the synthesis of peptide therapeutics

The University of Manchester Department of Chemistry
Peptides are essential in life and are widely used as therapeutic agents, vaccines, biomaterials and in other important applications. Read more
 Supervisor: Prof J Micklefield
 19 April 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Developing novel Electron Paramagnetic Resonance Methods for Pulsed Dipolar Spectroscopy and Quantum Information Processing

The University of Manchester Department of Chemistry
In the last decade significant improvements in the hardware available for Electron Paramagnetic Resonance measurements. Read more
 Supervisors: Dr A Bowen, Prof E McInnes, Prof D Collison, Prof R Winpenny
 Year round applications  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Developing novel light-induced in-situ Electron Paramagnetic Resonance (EPR) methods

The University of Manchester Department of Chemistry
Light-induced in-situ Electron Paramagnetic Resonance (EPR) studies are a growing field in both continuous wave and pulsed EPR. It can be used to monitor photoactivated chemical and biochemical reactions involving radical reagents, projects or intermediates. Read more
 Supervisors: Dr A Bowen, Prof D Collison, Dr A Golovanov
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Targeting the mechanism of small GTPase splice variant RAC1B using ligand design

The University of Manchester Faculty of Biology, Medicine and Health
RAC1 is a small GTPase protein that functions as a key signalling node downstream of various microenvironmental signalling pathways. Read more
 Supervisors: Dr RB Bryce, Dr S Butterworth, Dr T Jowitt, Dr A Ucar
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Sustainable Commodity Chemicals through Enzyme Engineering & Design (SuCCEED) - 4 posts available

The University of Manchester Department of Chemistry
SuCCEED is a BBSRC-funded Prosperity Partnership multi-million project between The University of Manchester and Shell. Commodity chemicals are produced on a global scale and normally derived from finite geological sources. Read more
 Supervisors: Dr N Dixon, Dr J Esteban Serrano, Prof A Green, Prof D Leys, Dr V Spallina, Prof M Turner, Dr J Winterburn
 30 June 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Modelling blood motion in deformable vessels

University of Dundee School of Science and Engineering
This project aims to introduce a novel approach in studying blood flow in deformable vessels by simultaneously considering both the fluid (blood) and the structure (vessel) through analytical and numerical approaches. Read more
 Supervisors: Dr M Hayatdavoodi, Prof P Lin
 30 June 2024  PhD Research Project  Self-Funded PhD Students Only
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Protein self assembly induced by multivalent biological metabolites

The University of Manchester Department of Chemical Engineering
In addition to being an energy source in biological reactions, recent discoveries suggest adenosine triphosphate (ATP) also plays a critical role in maintaining cell stability and preventing deleterious cellular processes through modulating biomacromolecular self assembly. Read more
 Supervisor: Dr R Curtis
 31 December 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Viral-surface interactions studied by vibrational sum-frequency spectroscopy

The University of Manchester Department of Materials
The recent COVID-19 pandemic, and in particular fomite transmission of the virus, led to a lot of interest in how viral particles attached to surfaces, their survival times on different materials and how they transferred to hosts. Read more
 Supervisors: Dr A Thomas, Dr R Lindsay
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the interaction of La related proteins with colliding ribosomes

The University of Manchester Faculty of Biology, Medicine and Health
Translation of mRNA into proteins is a critical cellular biological process for all life. This requires ribosomes to act with an array of translation factors to decode mRNA sequences. Read more
 Supervisors: Prof G D Pavitt, Dr A Roseman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Taking Light Induced Electron Paramagnetic Resonance In Cell for Biological Structural Determination

The University of Manchester Department of Chemistry
Studying the structure of proteins and other biological systems is an important step in understanding their function. Most structural studies are conducted in environments that are far away from native conditions, such as those found inside a cell. Read more
 Supervisors: Dr A Bowen, Dr J Rowbotham, Dr I Riddell, Dr D Heyes
 Year round applications  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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