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Structural Biology (human) PhD Projects, Programs & Scholarships

We have 49 Structural Biology (human) PhD Projects, Programs & Scholarships

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  Platform Technology to Enhance the Growth of Human Tissues In Vitro for Use in Biomedical Research and the Assessment of New Molecular Entities
  Prof S A Przyborski, Prof T von Zglinicki
Application Deadline: 29 May 2020

Funding Type

PhD Type

Many molecules fail when tested in humans as activity data do not always extrapolate into man. Accordingly, there is demand to develop new biomedical in-vitro assays to test compounds in human tissues earlier in product development.
  Exploiting the true joint progenitor cell for articular cartilage repair
  Prof D Chan
Applications accepted all year round

Funding Type

PhD Type

Articular cartilage facilitates the frictionless motion of synovial joints. However, once damaged from trauma or excessive loading in daily use, repair is very poor leading to osteoarthritis (OA), a huge medical and social burden.
  Single-molecule analysis of structure and function of human transcription complexes using DNA origami nano-robots
  Research Group: Structural Biology and Molecular Enzymology
  Dr A Revyakin, Prof D Panne
Application Deadline: 6 June 2020

Funding Type

PhD Type

DNA origami is a rapidly evolving area of nanotechnology in which self-assembly properties of the DNA double helix are harnessed to build three-dimensional structures on the dimensional scale of ~50 nm.
  Mass spectrometry analysis of human tissue to characterise cleavage events resulting in amyloid deposition associated with aortic aneurysm and dissection
  Dr J Madine, Prof C E Eyers
Applications accepted all year round

Funding Type

PhD Type

The most common form of localised amyloid occurs in the aorta (aortic medial amyloid; AMA) and is estimated to occur in 97% of Caucasian people over 50.
  Our Mission: to Educate, Nurture and Discover for the benefit of Human Health

Funding Type

PhD Type

Our ultimate purpose is to work in service of patients. RCSI was founded by Royal Charter on 11th February 1784, to set and support professional standards for surgical training and practice in Ireland.
  How human teeth form and how that process fails in the inherited condition amelogenesis imperfecta
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Amelogenesis is the process of enamel formation and is essential for the development of functional teeth. Amelogenesis imperfecta (AI) is a failure of that process.
  Deciphering protective factors for intervertebral disc degeneration for mechanistic insights and intervention potentials
  Prof D Chan
Applications accepted all year round

Funding Type

PhD Type

Intervertebral disc degeneration (IDD) can lead to a diversity of problems including low back pain and sciatica as two very painful symptomatic outcomes.
  Dissecting the tubulin diversity: understanding how tubulin isotypes regulate microtubule networks
  Dr J Ti
Applications accepted all year round

Funding Type

PhD Type

α/β-tubulin heterodimers form dynamic polymers, microtubules, that are central to cellular processes, such as cell division, cell migration, and organelle transportation.
  Insights into eye disease: understanding the molecular basis of age-related macular degeneration
  Prof T Day, Dr S Clark
Applications accepted all year round

Funding Type

PhD Type

Dysregulation of innate immunity has been implicated as playing a key role in the development of age-related macular degeneration (AMD) – a major form of blindness in the industrialised world (see [1-5]).
  Ligament and tendon repair using a specific population of joint progenitor cells
  Prof D Chan
Applications accepted all year round

Funding Type

PhD Type

Ligaments and tendons stabilize the musculoskeletal system, controlling mobility. Anterior cruciate ligament in knee joints restrict the dimension of joint movement, while Achilles tendon transmit forces from calf muscle to bone enabling locomotion of ankle joints.
  Deep Learning / Bioinformatics Approach for Protein-Protein Interaction Prediction
  Dr JC Nebel
Applications accepted all year round

Funding Type

PhD Type

Since most molecular processes rely on protein–protein interactions PPIs), knowledge of those interactions is extremely valuable for biomedical research and drug design.
  Novel Bioinformatics and Artificial Intelligence approaches for microbiome analysis (Ref: ET20/HLS/APP/BASHTON)
  Dr M Bashton
Application Deadline: 1 July 2020

Funding Type

PhD Type

The microbiome, the collective genomic entity of all microbiota - bacteria, archaea, fungi, protozoa, and viruses of an environment holds an immense amount of information, a considerable amount of improvement with respect to data analysis and real-time interpretation is still needed to bring research out of the lab and into everyday usage in our home environment and health system.
  Molecular mechanisms of herpesviral infection
  Dr A Golovanov
Applications accepted all year round

Funding Type

PhD Type

Herpes viruses are known to cause a wide range of human diseases, ranging from simple cold sores to cancer, Kaposi Sarcoma. Kaposi Sarcoma, for example, is a type of cancer which affects immunocompromised patients and is endemic in Africa, where it is linked with the spread of HIV infection and AIDS.
  Methionine adenosyltransferases in disease and regulation of gene expression
  Dr S Antonyuk, Prof S Hasnain
Applications accepted all year round

Funding Type

PhD Type

Transmethylation, the transfer of a methyl group from one molecule to another, is a fundamental chemical reaction that plays a central role in important biological processes such as gene expression, cell growth and apoptosis.
  Immunity to Influenza and Ebola viruses
  Prof A Townsend
Application Deadline: 24 July 2020

Funding Type

PhD Type

This started with the investigation of T cell recognition of peptides derived from intracellular proteins of Influenza (Townsend et al 1986), that evolved into the development of a live attenuated, single cycle Influenza vaccine, based on these principles (Powell et al, 2012; Baz et al, 2015, Holzer 2018).
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