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Structural Biology (science communication) PhD Projects, Programs & Scholarships

We have 28 Structural Biology (science communication) PhD Projects, Programs & Scholarships

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  MRC DiMeN Doctoral Training Partnership: Developing protein tools to target DNA damage response and repair in cancer cells
  Dr Q. Wu, Dr D Tomlinson
Application Deadline: 6 January 2020

Funding Type

PhD Type

DNA damage response (DDR) and repair play critical roles in influencing the efficiency and sensitivity of many cancer treatments.
  MRC DiMeN Doctoral Training Partnership: How do non-coding enhancer RNAs confer genetic risk in Amyotrophic Lateral Sclerosis (ALS)?
  Dr Dan Bose, Dr J Cooper-Knock
Application Deadline: 6 January 2020

Funding Type

PhD Type

Project. Amyotrophic Lateral Sclerosis (ALS) is an aggressive neurodegenerative disease with no effective therapy. The established genetic causes of ALS can only explain a small fraction of the observed disease phenotypes.
  MRC DiMeN Doctoral Training Partnership: How do non-coding enhancer RNAs confer genetic risk in Amyotrophic Lateral Sclerosis (ALS)?
  Dr Dan Bose, Dr J Cooper-Knock
Application Deadline: 6 January 2020

Funding Type

PhD Type

Project. Amyotrophic Lateral Sclerosis (ALS) is an aggressive neurodegenerative disease with no effective therapy. The established genetic causes of ALS can only explain a small fraction of the observed disease phenotypes.
  MRC DiMeN Doctoral Training Partnership: Drug discovery to control C. difficile infections by targeting sporulation
  Dr P Salgado, Dr J Hubbard
Application Deadline: 6 January 2020

Funding Type

PhD Type

Interested in a PhD studying antibiotic resistant bacteria and explore new ways to treat drug-resistant infections? In this PhD, you will use a range of biochemistry, biophysical and structural techniques, together with molecular biology, genetics, and microbiology approached to develop new therapeutics targeting C.
  MRC DiMeN Doctoral Training Partnership: How does mitochondrial morphology change in neurons with age and disease?
  Dr A Reeve, Dr C Racca, Dr A Vincent
Application Deadline: 6 January 2020

Funding Type

PhD Type

Mitochondria are fundamental to the function of our neurons, and defects in the function of this important organelle are found in several neurodegenerative disorders, as well as in normal ageing.
  MRC DiMeN Doctoral Training Partnership: Towards specialised treatments for childhood-onset neurological diseases
  Dr C Schneider, Prof R Horvath
Application Deadline: 6 January 2020

Funding Type

PhD Type

Neurodegeneration is a feature of many debilitating, incurable diseases with underlying defects in RNA metabolism (e.g. spinal muscular atrophy, ALS), but the link between RNA biology and neuronal death is poorly understood.
  MRC DiMeN Doctoral Training Partnership: Dissecting the function of long non-coding RNAs during neuronal differentiation and neuronal diseases
  Dr J Aspden, Dr G Hautbergue, Dr J Fontana
Application Deadline: 6 January 2020

Funding Type

PhD Type

Whilst 85% of our genome is transcribed, only 4% is protein-coding. In fact, many non-coding RNAs exist, some of which are similarly processed to mRNAs, termed long non-coding RNAs (lncRNAs).
  MRC DiMeN Doctoral Training Partnership: From atoms to organoids: understanding how abnormal cilia cause a neurodevelopmental disorder
  Dr T Ochi, Prof CA Johnson
Application Deadline: 6 January 2020

Funding Type

PhD Type

Eukaryotic primary cilia are the “antennae” of eukaryotic cells that detect and integrate a wide variety of environmental signals essential for photosensation in the eyes, chemosensation in the nose, and mechanosensation in the kidneys.
  MRC DiMeN Doctoral Training Partnership: Nanoinjection: a novel single molecule technique to study alpha-synuclein amyloid toxicity inside neurons
  Dr E W Hewitt, Dr P Actis, Prof S E Radford
Application Deadline: 6 January 2020

Funding Type

PhD Type

Project Aims. The aim of this project is to use nanoinjection to perform the quantitative delivery of alpha-synuclein fibrils or oligomers into the cytoplasm of neurons and then determine how many of each is required to induce cellular stress and death.
  MRC DiMeN Doctoral Training Partnership: The in situ 3D molecular structure of Alzheimer’s disease-associated pathology by cryo-electron microscopy
  Dr R Frank, Prof S E Radford, Dr E W Hewitt
Application Deadline: 6 January 2020

Funding Type

PhD Type

Synapses are the microprocessors of the mind that encode and store memories. In Alzheimer’s disease (AD), synapses are damaged by the constituents of abnormal beta-amyloid plaques that accumulate in the brain.
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