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Structural Biology (sexual) PhD Projects, Programs & Scholarships

We have 33 Structural Biology (sexual) PhD Projects, Programs & Scholarships

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  (BBSRC DTP) Isonitrile synthesizing nonheme iron enzymes: substrate scope and potential
  Research Group: Molecular Systems and Biomaterials
  Dr S De Visser, Dr A Green, Dr S Hay
Application Deadline: 31 January 2020

Funding Type

PhD Type

Cheap and efficient synthesis of drug molecules remains a challenge and often leads to a large amount of by-products. Nature has developed a large range of enzymes for Natural Product Synthesis, but only few of them are able to incorporate an isonitrile group into a substrate.
  (BBSRC DTP CASE) Design of a light-driven biocatalyst
  Prof D Leys, Dr S Hay
Application Deadline: 31 January 2020

Funding Type

PhD Type

Illumination is able to unlock a wide range of photochemical reactions, but light is rarely used by living organisms. In fact, to date only three light dependent enzymes have been described in detail.
  (BBSRC DTP CASE) Exploitation of P450 BM3 variants for production of valuable drug metabolites
  Prof A Munro, Prof D Leys
Application Deadline: 31 January 2020

Funding Type

PhD Type

The US Food and Drug Administration (FDA) have recommended that human drug metabolites (as well as their parent drugs) should be subject to testing for safety/toxicity.
  (BBSRC DTP CASE) Native Mass Spectrometry approaches for Electron and Photon mediated Top Down Sequencing of Biotherapeutics
  Prof P Barran, Prof S Flitsch
Application Deadline: 31 January 2020

Funding Type

PhD Type

Top down mass spectrometry, where the intact protein is introduced into the mass spectrometer and analysed as intact as well as after dissociation, offers several advantages over the more common bottom up approach, where the protein is digested into its constituent peptides before mass spectrometric analysis.
  (BBSRC DTP) A step change in the modelling of enzymatic catalysis
  Prof P Popelier, Dr L Johannissen, Dr S Hay
Application Deadline: 31 January 2020

Funding Type

PhD Type

A deep understanding of enzymatic processes requires an atomic-level description, which is often beyond the reach of experimental techniques but can be achieved through synergy with computational chemistry.
  (BBSRC DTP) A computational model for improving catalytic rate in enzymes
  Dr J Warwicker, Dr S De Visser, Dr S Hay
Application Deadline: 31 January 2020

Funding Type

PhD Type

Directed evolution of enzyme activity is an established methodology, generating biocatalysts that are of benefit for biotechnology, for example in bioenergy production [Turner 2009].
  (BBSRC DTP) Design and Evolution of Enzymes with Non-Canonical Catalytic Mechanisms
  Dr A Green, Prof M Greaney, Dr S Hay
Application Deadline: 31 January 2020

Funding Type

PhD Type

The ability to rationally design an enzyme for any desired transformation would have major impacts across the pharmaceutical and wider chemical sectors, leading to more efficient and sustainable synthetic routes to high value chemicals.
  (BBSRC DTP) Development of anti-cancer agents and biomarkers that target intrinsically disordered regions of transcription factors and protein kinases
  Prof J Waltho, Dr A Almond
Application Deadline: 31 January 2020

Funding Type

PhD Type

The controlled manipulation of transcription factors, protein kinases and protein phosphatases is central to improving our understanding of cellular processes and, importantly, in the development of next-generation therapeutics for a variety of cancers.
  (BBSRC DTP) Discovery and Editing Pathways to New Antibiotics
  Prof J Micklefield, Prof D Leys, Dr A Green
Application Deadline: 31 January 2020

Funding Type

PhD Type

There is an urgent need for new antibiotics. The majority of antibiotics that are used to treat infectious diseases today are small molecules produced by microorganisms, called natural products, or derivatives thereof.
  (BBSRC DTP) Electron Paramagnetic Resonance Pulsed Dipolar Spectroscopy for Structural Biology
  Dr A Bowen, Dr S Hay, Dr M Shanmugam
Application Deadline: 31 January 2020

Funding Type

PhD Type

Electron Paramagnetic Resonance is a rapidly expanding suit of techniques used for the study of complex (bio)molecules that possess spin-active moieties with unaired electrons.
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