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Structural Biology (transcription) PhD Projects, Programs & Scholarships

We have 10 Structural Biology (transcription) PhD Projects, Programs & Scholarships

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  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round

Funding Type

PhD Type

The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  PhD Studentship in Biosciences Institute – Understanding the role of transcription in organisation of bacterial chromosome
  Prof N Zenkin
Application Deadline: 5 February 2020

Funding Type

PhD Type

Number of awards. 1. Start date and duration. 28 September 2020. An early start date is possible. The funding covers a three year PhD.
  (BBSRC DTP) Development of anti-cancer agents and biomarkers that target intrinsically disordered regions of transcription factors and protein kinases
  Prof J Waltho, Dr A Almond
Application Deadline: 31 January 2020

Funding Type

PhD Type

The controlled manipulation of transcription factors, protein kinases and protein phosphatases is central to improving our understanding of cellular processes and, importantly, in the development of next-generation therapeutics for a variety of cancers.
  Characterization of cyclin-dependent kinases 12 and 11 (CDK12 and CDK11) in gene expression and tumorigenesis
  Dr D Blažek, Prof Z Zdrahal, Dr P Alexiou
Application Deadline: 20 February 2020

Funding Type

PhD Type

Cdk12 is transcriptional cyclin-dependent kinase (Cdk) found mutated in various cancers. In previous studies we found that Cdk12 maintains genome stability via optimal transcription of key homologous recombination repair pathway genes including BRCA1.
  A structural basis for the cross-talk between histones and RNA Polymerase II
  Prof R Stefl, Dr K Kubicek, Prof S Vanacova
Application Deadline: 1 February 2020

Funding Type

PhD Type

Chromatin is a highly flexible architecture in which spatially and temporally coordinated changes between structurally condensed states (transcriptionally repressive), and structurally accessible states (transcriptionally active) regulate gene expression.
  Cracking the CTD code
  Prof R Stefl, Dr K Kubicek, Dr P Plevka
Application Deadline: 20 February 2020

Funding Type

PhD Type

The concept of the CTD code that specifies the position of RNAPII in the transcriptional cycle and thus recruits specific processing factors, was suggested almost a decade ago.
  Structure, dynamics and interactions of Microtubule Associated Protein 2c and bacterial RNA polymerase subunits and sigma factors
  Prof L Zidek, Dr J Hritz
Application Deadline: 20 February 2020

Funding Type

PhD Type

Microtubule associated protein 2c (MAP2c) is a key factor regulating microtubule dynamics in developing brain neurons, and an example of an intrinsically disordered proteins with an important physiological function and detectable structure-function relationship.
  (BBSRC DTP) Complexity of heart development arising from evolution of signalling systems
  Dr K Hentges, Dr D Talavera, Prof S Lovell
Application Deadline: 31 January 2020

Funding Type

PhD Type

Protein families grow or shrink in size during evolution due to gene duplication and gene loss events. These events provide opportunities for protein function specialisation or innovation.
  (BBSRC DTP) Functional and structural analysis of RBBP5: a histone tail modifier essential for development, disease and healthy ageing
  Dr G Poulin, Prof A Sharrocks, Dr A J Whitmarsh
Application Deadline: 31 January 2020

Funding Type

PhD Type

The genome is the blueprint of any living system. However, it is the regulation of gene expression that enables life. For transcription to take place, the molecular machinery involved has to access genomic DNA.
  Targeting ubiquitin ligases with small molecules to develop new therapeutics (CHANTRYAU20SCIO)
  Dr A Chantry, Dr A M Hemmings
Application Deadline: 30 January 2020

Funding Type

PhD Type

Ubiquitination (the addition of ubiquitin to specific proteins) is a key regulatory mechanism for cellular processes such as protein turnover via the ubiquitin-proteasome system (UPS), trafficking, autophagy, subcellular localisation, transcription and DNA repair.
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