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Structural Biology (human) PhD Projects, Programs & Scholarships

We have 54 Structural Biology (human) PhD Projects, Programs & Scholarships

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Showing 1 to 15 of 54
  Understanding and predicting disease-associated mutations in dynamic and disordered regions of proteins
  Dr J Marsh
Application Deadline: 31 January 2020

Funding Type

PhD Type

Applications are invited from outstanding candidates to join the MRC Human Genetics Unit (HGU), part of the Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh.
  Exploiting the true joint progenitor cell for articular cartilage repair
  Prof D Chan
Applications accepted all year round

Funding Type

PhD Type

Articular cartilage facilitates the frictionless motion of synovial joints. However, once damaged from trauma or excessive loading in daily use, repair is very poor leading to osteoarthritis (OA), a huge medical and social burden.
  Mass spectrometry analysis of human tissue to characterise cleavage events resulting in amyloid deposition associated with aortic aneurysm and dissection
  Dr J Madine, Prof C E Eyers
Applications accepted all year round

Funding Type

PhD Type

The most common form of localised amyloid occurs in the aorta (aortic medial amyloid; AMA) and is estimated to occur in 97% of Caucasian people over 50.
  Our Mission: to Educate, Nurture and Discover for the benefit of Human Health

Funding Type

PhD Type

Our ultimate purpose is to work in service of patients. RCSI was founded by Royal Charter on 11th February 1784, to set and support professional standards for surgical training and practice in Ireland.
  Human chromosome segregation principles: Regulation of Astrin-PP1 interaction
  Prof VM Draviam, Prof RW Pickersgill, Dr JM Martin
Application Deadline: 31 January 2020

Funding Type

PhD Type

The School of Biological and Chemical Sciences at Queen Mary is one of the UK’s elite research centres, according to the 2014 Research Excellence Framework (REF).
  How human teeth form and how that process fails in the inherited condition amelogenesis imperfecta
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Amelogenesis is the process of enamel formation and is essential for the development of functional teeth. Amelogenesis imperfecta (AI) is a failure of that process.
  Structure and activity of carbohydrate-active enzymes associated with human disease
  Dr L Willems, Prof G Davies
Application Deadline: 1 February 2020

Funding Type

PhD Type

Proteins on the surface of mammalian cells are often modified with diverse, complex carbohydrate structures. These carbohydrates, named glycans, play key roles in a range of cellular processes including cell-cell and host-pathogen interactions.
  Structure and activity of carbohydrate-active enzymes associated with human disease
  Dr L Willems, Prof G Davies
Application Deadline: 1 February 2020

Funding Type

PhD Type

Proteins on the surface of mammalian cells are often modified with diverse, complex carbohydrate structures. These carbohydrates, named glycans, play key roles in a range of cellular processes including cell-cell and host-pathogen interactions.
  (BBSRC DTP CASE) Exploitation of P450 BM3 variants for production of valuable drug metabolites
  Prof A Munro, Prof D Leys
Application Deadline: 31 January 2020

Funding Type

PhD Type

The US Food and Drug Administration (FDA) have recommended that human drug metabolites (as well as their parent drugs) should be subject to testing for safety/toxicity.
  Deciphering protective factors for intervertebral disc degeneration for mechanistic insights and intervention potentials
  Prof D Chan
Applications accepted all year round

Funding Type

PhD Type

Intervertebral disc degeneration (IDD) can lead to a diversity of problems including low back pain and sciatica as two very painful symptomatic outcomes.
  Dissecting the tubulin diversity: understanding how tubulin isotypes regulate microtubule networks
  Dr J Ti
Applications accepted all year round

Funding Type

PhD Type

α/β-tubulin heterodimers form dynamic polymers, microtubules, that are central to cellular processes, such as cell division, cell migration, and organelle transportation.
  Insights into eye disease: understanding the molecular basis of age-related macular degeneration
  Prof T Day, Dr S Clark
Applications accepted all year round

Funding Type

PhD Type

Dysregulation of innate immunity has been implicated as playing a key role in the development of age-related macular degeneration (AMD) – a major form of blindness in the industrialised world (see [1-5]).
  Ligament and tendon repair using a specific population of joint progenitor cells
  Prof D Chan
Applications accepted all year round

Funding Type

PhD Type

Ligaments and tendons stabilize the musculoskeletal system, controlling mobility. Anterior cruciate ligament in knee joints restrict the dimension of joint movement, while Achilles tendon transmit forces from calf muscle to bone enabling locomotion of ankle joints.
  RVC PhD: Gene therapy for cartilage regeneration in osteoarthritis
  Dr S Roberts, Prof A Pitsillides, Dr J Dudhia
Application Deadline: 9 February 2020

Funding Type

PhD Type

Osteoarthritis (OA) is the most common form of arthritis in humans. By 2050 it is estimated that 40 million people worldwide will be severely disabled by this disease.
  Deep Learning / Bioinformatics Approach for Protein-Protein Interaction Prediction
  Dr JC Nebel
Applications accepted all year round

Funding Type

PhD Type

Since most molecular processes rely on protein–protein interactions PPIs), knowledge of those interactions is extremely valuable for biomedical research and drug design.
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