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Structural Biology (recombinant) PhD Projects, Programs & Scholarships

We have 20 Structural Biology (recombinant) PhD Projects, Programs & Scholarships

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  Oxidative protein folding of industrially and pharmaceutically important recombinant proteins
  Dr H Lu, Dr A Day
Applications accepted all year round

Funding Type

PhD Type

Oxidative protein folding is an important process for the function of many proteins, which includes both folding and formation of native disulphide bonds.
  Developing a virus-like particle (VLP) Polio vaccine
  Dr G Mulley
Applications accepted all year round

Funding Type

PhD Type

Rationale. Poliovirus is a non-enveloped RNA virus, spread via the faecal-oral route, that causes the infectious disease Poliomyelitis (Polio).
  From Fragment-screening to Fragment-growing - new strategies for drug discovery
  Dr E Pohl, Dr C Cano
Application Deadline: 6 March 2020

Funding Type

PhD Type

Type-2 diabetes represents a major health problem in particular in industrialised countries and although many cases may be preventable by lifestyle changes, numbers are steadily rising.
  From Fragment-screening to Fragment-growing - new strategies for drug discovery - EPSRC Centre for Doctoral Training (CDT) in Molecular Sciences for Medicine (MoSMed)
  Dr E Pohl
Application Deadline: 6 March 2020

Funding Type

PhD Type

Type-2 diabetes, also known as adult-onset diabetes is the most common form of this disease affecting between 150 and 400 million people worldwide.
  Unravelling the mysteries of retinoid signalling
  Dr E Pohl, Prof J Endicott
Application Deadline: 6 March 2020

Funding Type

PhD Type

Retinoids, such as all-trans-retinoic acid (ATRA), are a class of endogenous molecules derived from Vitamin A. These compounds control a wide range of cellular processes in chordates, including differentiation, proliferation and apoptosis, by binding one or more of related transcriptional receptors in the cell nucleus.
  Developing Drug Discovery Assays for Primary Human Immune Cells by High-Throughput MALDI-TOF Mass Spectrometry
  Prof M Trost, Dr M Dueñas
Application Deadline: 6 March 2020

Funding Type

PhD Type

MALDI-TOF mass spectrometry (MS) is a powerful MS method that has emerged as an exciting technology high-throughput drug discovery workflows.
  Structure/function studies of component proteins of anti-feeding prophage (Afp), a bacteriophage tail-like particle using high-resolution cryo-EM and x-ray crystallography
  Prof A Mitra
Applications accepted all year round

Funding Type

PhD Type

We are seeking a highly motivated candidate to carry out structure/function studies of component proteins of anti-feeding prophage (Afp), a bacteriophage tail-like particle using high-resolution cryo-EM and x-ray crystallography.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round

Funding Type

PhD Type

The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  MRC DTP 4 Year PhD Programme: Structural and developmental mechanics in polarized membrane trafficking
  Dr D H Murray, Dr J Januschke
Application Deadline: 13 March 2020

Funding Type

PhD Type

This project is offered as part of the University of Dundee 4-year MRC DTP Programme “Quantitative and Interdisciplinary approaches to biomedical science”.
  Cloning and expression of topoisomerase genes from Trypanosoma brucei (SteverdingD-2U19SF)
  Dr D Steverding
Application Deadline: 31 May 2020

Funding Type

PhD Type

Topoisomerases (TOPs) are essential enzymes that catalysis topological changes in DNA. TOPs are pivotal to cell survival and therefore inhibitors have been developed to target these enzymes both for antimicrobial and anti-cancer chemotherapy.
  Dissecting the tubulin diversity: understanding how tubulin isotypes regulate microtubule networks
  Dr J Ti
Applications accepted all year round

Funding Type

PhD Type

α/β-tubulin heterodimers form dynamic polymers, microtubules, that are central to cellular processes, such as cell division, cell migration, and organelle transportation.
  Evolutionary insights for engineering improved globin oxygen carriers
  Dr M Berenbrink, Dr J Madine
Applications accepted all year round

Funding Type

PhD Type

Around 2 million red blood cell units at a cost of 120.00 GBP per unit are transfused annually in England alone (http://www.nhsbt.nhs.uk/what-we-do/blood-transfusion/).
  Regulating biosynthesis of the pigments of life
  Dr A Hitchcock, Dr P Jackson, Prof C N Hunter
Application Deadline: 31 March 2020

Funding Type

PhD Type

Tetrapyrroles are often referred to as the pigments of life as they are required for a number of vital cellular processes, including respiration (haems), photosynthesis (chlorophylls), amino acid biosynthesis (vitamin B12), sulphur and nitrogen assimilation (sirohaem) and methanogenesis (cofactor F430).
  The molecular basis of a genetic susceptibility gene in Alzheimer’s disease: the case of cystatin C
  Dr R Staniforth
Applications accepted all year round

Funding Type

PhD Type

Degenerative diseases associated with ageing occur sporadically and are associated with the misfolding and aggregation of a number of proteins in vivo.
  Dissecting the role of MCE proteins in Cyanobacteria
  Dr V Darbari, Prof C Mullineaux
Applications accepted all year round

Funding Type

PhD Type

The School of Biological and Chemical Sciences at Queen Mary is one of the UK’s elite research centres, according to the 2014 Research Excellence Framework (REF).
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