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We have 124 Structural Biology PhD Projects, Programmes & Scholarships

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Structural Biology PhD Projects, Programmes & Scholarships

We have 124 Structural Biology PhD Projects, Programmes & Scholarships

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(MRC DTP CASE) Development of new in vitro infection models to tackle antimicrobial resistance

The University of Manchester Faculty of Biology, Medicine and Health
Antimicrobial resistance (AMR) is one of the most serious global public health threats in this century. Read more
 Supervisors: Dr S Gago, Dr M Bertuzzi, Dr J Bella
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Advancing Liquid Atmospheric Pressure (LAP) MALDI Mass Spectrometry

University of Reading School of Chemistry & Food
MALDI. mass spectrometry has been a cornerstone of modern biological mass. spectrometry, enabling the soft ionization, analysis and characterisation of. Read more
 Supervisor: Prof R K Cramer
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Understanding control of genome folding by cohesin

University of Leicester Molecular and Cell Biology
Our basic goal is to understand how chromatin structure influences gene regulation. Chromatin is generally repressive in nature but its structure is manipulated by cells in a regulated way to determine which genes are potentially transcriptionally active and which genes remain repressed in a given cell type. Read more
 Supervisors: Prof D Panne, Dr T Schalch
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Revealing Reactivity in Cancer-Associated Heme Proteins: Novel Time-Resolved Structural Approaches

University of Leicester Molecular and Cell Biology
Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme involved in the degradation of tryptophan to kynurenine. Cancer cells upregulate IDO1 to escape normal immune responses and, in many cases, a high expression of IDO1 is connected to poor prognosis. Read more
 Supervisors: Dr HK Kwon, Dr P A Ash
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Chemical energy conversion in biology studied using advanced spectroscopic and structural tools

University of Leicester Department of Chemistry
Redox properties of metal-containing active sites are critically important to many biocatalytic processes. one third of all proteins contain a redox-active metal, and ca 22% of submissions to the Protein Data Bank contain a transition metal. Read more
 Supervisors: Dr PA Ash, Dr H Kwon
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Natural products in bacterial physiology and chemical interaction

University of Leicester Department of Genetics and Genome Biology
Microbial natural products have diverse chemical structures and bioactivities, which range from cell-cell signalling, nutrient acquisition, antifungal and antibacterial activity to stress resistance (1). Read more
 Supervisors: Dr C Jenul, Prof D Jones
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Obtaining insights into how a signalling hub protein Ras activates multiple effectors

University of Leicester Molecular and Cell Biology
The RAS family of small GTPases act as signalling hubs regulating cell proliferation and differentiation. They are highly conserved from yeast to humans, highlighting their fundamental biological roles. Read more
 Supervisors: Dr K Tanaka , Dr R Mahen
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Unlocking the Secrets of Genome Regulation through cryo-EM

University of Leicester Molecular and Cell Biology
Are you an ambitious spirit, ready to make breakthrough discoveries at the frontier of epigenetics? Dive deep into the fascinating world of eukaryotic genomes with us! . Read more
 Supervisors: Dr T Schalch, Dr AC Chaplin
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Molecular level understanding of Mycobacterium tuberculosis

University of Leicester Department of Respiratory Sciences
Mycobacterium tuberculosis has evolved to survive and replicate inside macrophages. The project will investigate the molecular mechanisms underpinning adaptation to this specialised intracellular niche. Read more
 Supervisors: Dr H O'Hare, Dr N Garton
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Epigenetics of early human development: From molecular mechanisms to regenerative medicine

University of Leicester Molecular and Cell Biology
Ever wondered how nature maintains balance of gene expression between sex chromosomes? Well, the 46th chromosome of XX females, the second X, has to be switched off. Read more
 Supervisors: Dr Y Markaki, Dr T Schalch
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Understanding centrosome function in the human airway

University of Leicester Molecular and Cell Biology
Breathing sustains our life and is also important for our quality of life. Inside the lung, billions of hair-like structures called cilia beat a million times a day to promote a process called mucociliary clearance. Read more
 Supervisors: Dr R Mahen, Prof EH Hollox
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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(MRC DTP CASE) Prediction of substrate binding geometry and strength in promiscuous enzymes: computational chemistry applicable to the design of pharmaceuticals and agrochemicals

The University of Manchester Faculty of Biology, Medicine and Health
We are often taught about the power of enzymes to select particular substrates from the biological milieu and of their ability to perform highly selective reactions on those substrates. Read more
 Supervisors: Dr A Leach, Dr S De Visser, Dr C Trujillo
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Structural-guided PROTAC targeting of BMX to modulate apoptotic sensitivity in disease

University of Leicester Molecular and Cell Biology
What determines at the molecular level whether a cell lives or dies? Regulation of the cellular life–death switch is essential in healthy cells for normal foetal development and for the clearance of damaged cells. Read more
 Supervisors: Dr JF Fox, Dr JH Hodgkinson
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Molecular Glues as Novel Tools for Tackling Big Challenges in Human Health

University of Leicester Department of Chemistry
Background. The need for new medicines is greater than ever because of an ageing population and the complex clinical challenges brought about by drug resistance and/or side effects. Read more
 Supervisors: Dr RD Doveston, Prof S Macip
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Molecular characterization of Sam68-driven cytoskeletal reorganization

University of Leicester Molecular and Cell Biology
The cytoskeleton is a complex network of various fibres (microtubules, actin, …) that is essential for cells to maintain their shape and internal organization and for their migration. Read more
 Supervisors: Dr C Dominguez, Prof A Fry
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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(MRC DTP CASE) An Integrative Structural Biology Platform for Drug Discovery

The University of Manchester Faculty of Biology, Medicine and Health
Solute carriers (SLCs) are the second largest class of membrane-embedded proteins with over 400 members organised into 66 families. Read more
 Supervisors: Dr A Politis, Dr CP Pliotas
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Alpha-synuclein amyloid in Parkinson's disease: using Nanoinjection as a tool to study alpha-synuclein amyloid toxicity inside neurons

University of Leeds Faculty of Biological Sciences
Intraneuronal inclusions known as Lewy bodies are a hallmark of Parkinson’s disease. Amyloid fibrils formed by the misfolding of alpha-synuclein are the principal component of Lewy Bodies. Read more
 Supervisors: Dr E W Hewitt, Prof S E Radford, Dr P Actis
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Control and inhibition of virus replication

University of Leeds Faculty of Biological Sciences
The Tuplin laboratory utilises a range of cutting-edge approaches to investigate how arboviruses - specifically Chikungunya, Dengue and Zika viruses - control replication and translation of their genomes through interactions between RNA structures, host cell proteins and non-coding RNA, and the potential of such RNA elements/interactions as novel therapeutic targets. Read more
 Supervisor: Dr A.K Tuplin
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Delivery and misdelivery of outer membrane proteins to the BAM complex using cryoEM

University of Leeds Faculty of Biological Sciences
The BAM complex folds membrane proteins into the outer membrane of Gram-negative bacteria, proteins whose functions are essential for bacterial viability, pathogenicity and virulence. Read more
 Supervisors: Prof N A Ranson, Prof S E Radford
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Design and Folding of beta barrel membrane proteins

University of Leeds Faculty of Biological Sciences
The cell walls of Gram negative bacteria are packed with b-barrel outer membrane proteins (OMPs) whose function are essential for bacterial growth and virulence. Read more
 Supervisors: Prof S E Radford, Prof D B Brockwell
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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How does myosin 10 contribute to filopodia formation and stability?

University of Leeds Faculty of Biological Sciences
How do cells make filopodia? Filopodia are thin protrusions that act as pathfinders in cell migration, helping cells to sense where to go, and pulling cells through the extracellular matrix, especially important in driving cancer cell metastasis. Read more
 Supervisors: Prof M Peckham, Dr D Tomlinson
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Using cryo-electron microscopy to study large protein complexes that mediate the female post-mating response

University of Leeds Faculty of Biological Sciences
In many animals, male seminal fluid alters female physiology and post-mating behaviour to ensure paternity of the offspring. However, how seminal fluid components elicit these post-mating responses is poorly understood. Read more
 Supervisors: Dr J.J.B. Cockburn, Prof R E Isaac
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Engineering Developable Biopharmaceuticals

University of Leeds Faculty of Biological Sciences
The School of Molecular and Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more
 Supervisors: Prof D B Brockwell, Prof S E Radford
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Uncovering the viral and cellular components that dictate the neurological outcome of tick-borne encephalitis virus infection

University of Leeds Faculty of Biological Sciences
The School of Molecular and Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more
 Supervisor: Dr NG Goonawardane
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Structural and mechanistic studies of fibroblast growth factor receptor signalling

University of Leeds Faculty of Biological Sciences
The School of Molecular and Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more
 Supervisors: Prof A.L. Breeze, Prof F. Sobott
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Machine Learning and Molecular Modelling in Mass Spectrometry

University of Leeds Faculty of Biological Sciences
This PhD project will harness the power of computational modelling and machine learning (A.I.) to analyse data obtained by mass spectrometry experiments and predict structural characteristics of biomolecules and their interactions. Read more
 Supervisors: Prof F. Sobott, Dr A Kalli, Dr H Wang
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Seeing inside the brain of Alzheimer’s disease by cryoET

University of Leeds Faculty of Biological Sciences
The aim of this PhD project is to determine the in situ 3D molecular structures associated with AD to understand disease mechanisms and molecular pathways that can lead to the rational design of a mechanism-based therapy. Read more
 Supervisor: Dr R Frank
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The role of ubiquitin-modifying enzymes in angiogenesis

University of Leeds Faculty of Biological Sciences
The School of Molecular & Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more
 Supervisors: Dr S Ponnambalam, Dr M A Harrison
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Untangling the role of beta-1,3 glucan polymers in intercellular communication

University of Leeds Faculty of Biological Sciences
Apply to join the Benitez-Alfonso team in their quest to dissect the mechanisms underpinning the function of beta-1,3 glucan polymers in plant growth and development. . Read more
 Supervisor: Dr Y Benitez-Alfonso
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Uncovering the links between the environmental sensor, AHR, and the development of breast cancer

University of Leeds Faculty of Biological Sciences
The School of Molecular and Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more
 Supervisors: Dr C Gorrini, Dr A Zhuravleva
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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