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Structural Biology (action research) PhD Projects, Programs & Scholarships

We have 10 Structural Biology (action research) PhD Projects, Programs & Scholarships

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  Immunity to Influenza and Ebola viruses
  Prof A Townsend
Application Deadline: 24 July 2020

Funding Type

PhD Type

This started with the investigation of T cell recognition of peptides derived from intracellular proteins of Influenza (Townsend et al 1986), that evolved into the development of a live attenuated, single cycle Influenza vaccine, based on these principles (Powell et al, 2012; Baz et al, 2015, Holzer 2018).
  Immunity to Influenza and Ebola viruses
  Prof A Townsend
Application Deadline: 24 July 2020

Funding Type

PhD Type

This started with the investigation of T cell recognition of peptides derived from intracellular proteins of Influenza (Townsend et al 1986), that evolved into the development of a live attenuated, single cycle Influenza vaccine, based on these principles (Powell et al, 2012; Baz et al, 2015, Holzer 2018).
  The mechanism of regulation of protein synthesis via eIF2 molecular complexes
  Dr A Roseman, Prof G D Pavitt
Applications accepted all year round

Funding Type

PhD Type

Control of protein synthesis is critical for normal metabolism, development and responses to stress. One major pathway is called the integrated stress response (ISR) and centres on translational control of the general protein synthesis factor eIF2B via the phosphorylation of eIF2 [1,2].
  Protein Misfolding and the Molecular Basis of Alzheimer’s Disease
  Dr J Viles
Applications accepted all year round

Funding Type

PhD Type

Background. World-wide one in three people over the age of 65 will die with Alzheimer’s Disease (AD). The disease is characterised by deposits of amyloid plaques and fibrils of amyloid-beta peptide (Ab) are their main constituent.
  The role of Efflux in Antibiotic Resistance of Clinically Relevant Pathogens
  Dr J Blair
Applications accepted all year round

Funding Type

PhD Type

Antibiotics underpin all of modern medicine; they are used to treat bacterial infections, and to prevent infections after surgery and in patients with a suppressed immune system such as those undergoing cancer chemotherapy or organ transplantation.
  FoodBioSystems DTP - A receptor-ligand module that triggers cell death in plants: a killer in disguise
  Dr M Bosch, Dr L J McGuffin, Prof G J Stephens
Application Deadline: 6 March 2020

Funding Type

PhD Type

Research Group. FOODBIOSYSTEMS BBSRC DTP. Most of our food is a product of plant reproduction with fertility and seed set critical for crop yield and thus food security.
  Using single molecule spectroscopy to determine the drivers of conformational change in protein kinases
  Dr C Dodson
Applications accepted all year round

Funding Type

PhD Type

Protein kinases are central to many cellular processes (eg cell division and the response to external signals) and are current drug targets in cancer, cardiac and inflammatory disease.
  Characterisation of bacterial effectors delivered by the type VI secretion system
  Dr M Thomas
Applications accepted all year round

Funding Type

PhD Type

Many pathogenic bacteria secrete protein ’effectors’ that benefit the pathogen by allowing it to subvert, damage or kill the host.
  Structural Biology of Wnt Signalling
  Dr K Tripsianes
Application Deadline: 20 February 2020

Funding Type

PhD Type

We apply structural biology methods in order to gain a mechanistic view of CK1ε action in the Wnt signalling pathways. CK1ε represents an attractive therapeutic target but currently two key steps in the CK1ε-mediated Wnt signal transduction are unclear.
  How human teeth form and how that process fails in the inherited condition amelogenesis imperfecta
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Amelogenesis is the process of enamel formation and is essential for the development of functional teeth. Amelogenesis imperfecta (AI) is a failure of that process.
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