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Structural Biology (information studies) PhD Projects, Programs & Scholarships

We have 43 Structural Biology (information studies) PhD Projects, Programs & Scholarships

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Showing 1 to 30 of 43
  Experimental and Theoretical Studies of the Origin of Life on the Earth
  Prof J Šponer, Ms J Sponerova
Application Deadline: 20 February 2020

Funding Type

PhD Type

Formation of the very first oligonucleotide sequences is one of the greatest mysteries surrounding life’s origin on our planet.
  Deciphering protective factors for intervertebral disc degeneration for mechanistic insights and intervention potentials
  Prof D Chan
Applications accepted all year round

Funding Type

PhD Type

Intervertebral disc degeneration (IDD) can lead to a diversity of problems including low back pain and sciatica as two very painful symptomatic outcomes.
  Bioinformatics studies of protein structures, functions and their interactions
  Dr L J McGuffin
Applications accepted all year round

Funding Type

PhD Type

The computational study of protein structures, functions and their interactions is fundamental to our understanding of disease.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round

Funding Type

PhD Type

The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  Multiscale Modeling of Nucleic Acids
  Prof J Šponer, Prof M Otyepka, Dr MK Krepl
Application Deadline: 1 February 2020

Funding Type

PhD Type

Nucleic acids (RNA and DNA) belong to the most important biomacromolecules. Studies of structure and dynamics of nucleic acids represent an important task of modern life sciences.
  Structure/function studies of component proteins of anti-feeding prophage (Afp), a bacteriophage tail-like particle using high-resolution cryo-EM and x-ray crystallography
  Prof A Mitra
Applications accepted all year round

Funding Type

PhD Type

We are seeking a highly motivated candidate to carry out structure/function studies of component proteins of anti-feeding prophage (Afp), a bacteriophage tail-like particle using high-resolution cryo-EM and x-ray crystallography.
  Oxidative protein folding of industrially and pharmaceutically important recombinant proteins
  Dr H Lu, Dr A Day
Applications accepted all year round

Funding Type

PhD Type

Oxidative protein folding is an important process for the function of many proteins, which includes both folding and formation of native disulphide bonds.
  Defining a novel assembly pathway in ssRNA viruses using X-ray footprinting.
  Prof P G Stockley
Applications accepted all year round

Funding Type

PhD Type

Project co-supervised by Prof. Peter Stockley at Leeds and Prof. Reidun Twarock at University of York, as part of the White Rose network "Structural and Mechanistic Biology at the RNA/Ligand Interface".
  Structural and time-resolved studies of phage replication in bacterial biofilm
  Dr P Plevka
Application Deadline: 20 February 2020

Funding Type

PhD Type

When Staphylococcus aureus cells form a biofilm in the human body they become shielded from the immune system and highly resistant to antibiotics.
  Structural studies of the TPLATE complex
  Dr K Tripsianes
Application Deadline: 20 February 2020

Funding Type

PhD Type

The TPLATE complex (TPC) is essential for endocytosis in plants, yet it is evolutionary lost from yeasts and animals, pointing to the fact that endocytosis is mechanistically regulated differently.
  Understanding the mechanism of RNA recognition by La-related proteins
  Prof MR Conte
Applications accepted all year round

Funding Type

PhD Type

A PhD studentship is available to work in the laboratory of Prof. Sasi (Maria R) Conte (https://www.kcl.ac.uk/people/sasi-conte), in the Randall Centre for Cell and Molecular Biophysics, King’s College London (https://www.kcl.ac.uk/lsm/research/divisions/randall).
  Investigation of aortic remodelling in obesity and role of mitochondrial dysfunction
  Dr A Kitmitto, Dr E Cartwright
Applications accepted all year round

Funding Type

PhD Type

Obesity is a global healthcare and economic burden with currently more than 650 million adults classified as obese (WHO, 2017). Obesity is a common precursor to type 2 diabetes (T2DM), and both are risk factors for developing cardiovascular disease.
  Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas
  Research Group: School of Molecular and Cellular Biology
  Dr J Boyes
Application Deadline: 1 April 2020

Funding Type

PhD Type

V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas.
  Metabolomic studies of E. coli adaptation from anaerobic to aerobic growth
  Prof M P Williamson
Applications accepted all year round

Funding Type

PhD Type

Escherichia coli is a commensal organism that lives in the human gut. Occasionally it gives rise to food poisoning incidents, but mainly it is important for digestion and uptake of nutrients.
  Characterization of cyclin-dependent kinases 12 and 11 (CDK12 and CDK11) in gene expression and tumorigenesis
  Dr D Blažek, Prof Z Zdrahal, Dr P Alexiou
Application Deadline: 20 February 2020

Funding Type

PhD Type

Cdk12 is transcriptional cyclin-dependent kinase (Cdk) found mutated in various cancers. In previous studies we found that Cdk12 maintains genome stability via optimal transcription of key homologous recombination repair pathway genes including BRCA1.
  The chemistry and biophysics of phosphoryl transfer enzymes
  Prof J Waltho, Dr A Almond
Applications accepted all year round

Funding Type

PhD Type

One of the most remarkable features of the chemistry of living organisms is the evolutionary utilisation of phosphate esters to provide biopolymers that encode genetic information, deliver temporal protein regulation, generate and distribute free energy throughout the cell, and to provide a ubiquitous handle for metabolic intermediates.
  Exploiting the true joint progenitor cell for articular cartilage repair
  Prof D Chan
Applications accepted all year round

Funding Type

PhD Type

Articular cartilage facilitates the frictionless motion of synovial joints. However, once damaged from trauma or excessive loading in daily use, repair is very poor leading to osteoarthritis (OA), a huge medical and social burden.
  Understanding structure and drug binding in the multidrug pump ABCG2
  Dr I Kerr, Dr R Layfield
Applications accepted all year round

Funding Type

PhD Type

ABCG2 is one of three human ATP binding cassette transporters that are functionally capable of exporting a diverse range of substrates from cells.
  Structure, function and evolution of plant telomere components
  Prof J Fajkus, Prof J Palecek
Application Deadline: 20 February 2020

Funding Type

PhD Type

Telomeres are terminal, but nevertheless integral parts of chromosomes, and as such they are also formed and function as supramolecular nucleoprotein (chromatin) structures.
  Structure-functional study of proteins involved in host cell recognition
  Prof M Wimmerová
Application Deadline: 20 February 2020

Funding Type

PhD Type

Lectins are ubiquitous carbohydrate-binding proteins, which play a key role in various processes including cell-cell communication and host-pathogen interaction, but also serve as a valuable tool for medicine and life sciences research.
  International Ph.D. Programs in the Life Sciences

Funding Type

PhD Type

The Life Science Zurich Graduate School consists of several highly competitive Ph.D. programs. We are run jointly by the ETH Zurich and the University of Zurich.
  Human chromosome segregation principles: Regulation of Astrin-PP1 interaction
  Prof VM Draviam, Prof RW Pickersgill, Dr JM Martin
Application Deadline: 31 January 2020

Funding Type

PhD Type

The School of Biological and Chemical Sciences at Queen Mary is one of the UK’s elite research centres, according to the 2014 Research Excellence Framework (REF).
  (BBSRC DTP) Understanding structure and function of the mechanosensors talin and vinculin
  Dr C Ballestrem, Prof C Baldock, Dr A Roseman
Application Deadline: 31 January 2020

Funding Type

PhD Type

The ability of cells to sense biochemical and mechanical properties of their extracellular matrix (ECM) environment is critical for the development of functional tissue.
  Analysis of pathogen determinants recognized by the hypervariable immune receptor Dscam
  Dr M Soller
Application Deadline: 31 January 2020

Funding Type

PhD Type

Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response.
  Cloning and expression of topoisomerase genes from Trypanosoma brucei (SteverdingD-2U19SF)
  Dr D Steverding
Application Deadline: 31 May 2020

Funding Type

PhD Type

Topoisomerases (TOPs) are essential enzymes that catalysis topological changes in DNA. TOPs are pivotal to cell survival and therefore inhibitors have been developed to target these enzymes both for antimicrobial and anti-cancer chemotherapy.
  Targeting ubiquitin ligases with small molecules to develop new therapeutics (CHANTRYAU20SCIO)
  Dr A Chantry, Dr A M Hemmings
Application Deadline: 30 January 2020

Funding Type

PhD Type

Ubiquitination (the addition of ubiquitin to specific proteins) is a key regulatory mechanism for cellular processes such as protein turnover via the ubiquitin-proteasome system (UPS), trafficking, autophagy, subcellular localisation, transcription and DNA repair.
  Ligament and tendon repair using a specific population of joint progenitor cells
  Prof D Chan
Applications accepted all year round

Funding Type

PhD Type

Ligaments and tendons stabilize the musculoskeletal system, controlling mobility. Anterior cruciate ligament in knee joints restrict the dimension of joint movement, while Achilles tendon transmit forces from calf muscle to bone enabling locomotion of ankle joints.
  Novel microbial source tracking markers for identification of fecal contaminations in inflow rivers of Taihu Lake
  Dr S Raju, Prof A J McCarthy
Applications accepted all year round

Funding Type

PhD Type

The urban water system in China faces various challenges. Fecal pollution is one of the major concerns to watersheds. Taihu Lake serves as important drinking water source for many nearby cities in addition to many other roles including aquaculture, transportation and tourism.
  Developing a clinical tool to quantitatively assess and monitor upper limb and shoulder function in clinical and home settings
  Dr A Shaheen
Applications accepted all year round

Funding Type

PhD Type

Upper limb and shoulder disorders are poorly defined, diagnosed and rehabilitated. Current management of these disorders is focussed on the prescription of physiotherapeutic treatments, yet the efficacy of such treatments is not well established and the prognosis of patients with shoulder disorders is very poor.
  A structural basis for the cross-talk between histones and RNA Polymerase II
  Prof R Stefl, Dr K Kubicek, Prof S Vanacova
Application Deadline: 1 February 2020

Funding Type

PhD Type

Chromatin is a highly flexible architecture in which spatially and temporally coordinated changes between structurally condensed states (transcriptionally repressive), and structurally accessible states (transcriptionally active) regulate gene expression.
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