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Structural Biology (information systems) PhD Projects, Programs & Scholarships

We have 28 Structural Biology (information systems) PhD Projects, Programs & Scholarships

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  EPSRC Centre for Doctoral Training in Sustainable Approaches to Biomedical Science: Responsible and Reproducible Research - SABS

Funding Type

PhD Type

Good degree in the Physical or Life Sciences? Interested in biological or medical research? We offer fully-funded PhD places across the Oxford Doctoral Training Centre programmes.
  Harnessing Reactive Phosphorylating Agents for Peptide Bioconjugations
  Dr D Hodgson, Prof I Hickson, Prof M Noble
Application Deadline: 6 March 2020

Funding Type

PhD Type

Protein-protein interactions (PPIs) are central to signalling processes associated with many diseases. Disruption of PPI-mediated pathways offers new therapeutic targets, with great potential for selective, potent inhibition because they can mimic native protein structures.
  20 Funded PhD Positions in the IMPRS-CellDevoSys - Integrating Biology, Physics, Chemistry & Computer Science

Funding Type

PhD Type

A 4-year PhD Program involving 3 renowned international institutes. the Max Planck Institute of Molecular Cell Biology and Genetics, the Center for Systems Biology Dresden, and the Max Planck Institute for the Physics of Complex Systems.
  20 Funded PhD Positions in the IMPRS-CellDevoSys - Integrating Biology, Physics, Chemistry & Computer Science

Funding Type

PhD Type

A 4-year PhD Program involving 3 renowned international institutes. the Max Planck Institute of Molecular Cell Biology and Genetics, the Center for Systems Biology Dresden, and the Max Planck Institute for the Physics of Complex Systems.
  From Fragment-screening to Fragment-growing - new strategies for drug discovery
  Dr E Pohl, Dr C Cano
Application Deadline: 6 March 2020

Funding Type

PhD Type

Type-2 diabetes represents a major health problem in particular in industrialised countries and although many cases may be preventable by lifestyle changes, numbers are steadily rising.
  Oxidative protein folding of industrially and pharmaceutically important recombinant proteins
  Dr H Lu, Dr A Day
Applications accepted all year round

Funding Type

PhD Type

Oxidative protein folding is an important process for the function of many proteins, which includes both folding and formation of native disulphide bonds.
  Proteomic approach to understand mitochondrial quality control under normal and stress conditions
  Dr H Lu, Prof S Hubbard
Applications accepted all year round

Funding Type

PhD Type

Defects in protein quality control lead to the accumulation of misfolded and damaged proteins, which play an important role in many diseases (e.g.
  Observing Nucleic Acid Aptamer Binding with Ultrafast 2D-IR Spectroscopy
  Prof N Hunt
Applications accepted all year round

Funding Type

PhD Type

The project will be a collaboration with Prof Glenn Burley (University of Strathclyde). Background. The strong and specific binding of small molecules and proteins to DNA has relevance across many areas, from fundamental biophysics, through chemical biology to nanotechnology.
  PhD Student Positions at International Max Planck Research School for Molecular Life Sciences, Munich

Funding Type

PhD Type

The International Max Planck Research School for Molecular Life Sciences. From Biological Structures to Neural Circuits (IMPRS-LS) currently has an open call for fully funded PhD student positions.
  PhD Student Positions at International Max Planck Research School for Molecular Life Sciences, Munich

Funding Type

PhD Type

The International Max Planck Research School for Molecular Life Sciences. From Biological Structures to Neural Circuits (IMPRS-LS) currently has an open call for fully funded PhD student positions.
  Developing Drug Discovery Assays for Primary Human Immune Cells by High-Throughput MALDI-TOF Mass Spectrometry
  Prof M Trost, Dr M Dueñas
Application Deadline: 6 March 2020

Funding Type

PhD Type

MALDI-TOF mass spectrometry (MS) is a powerful MS method that has emerged as an exciting technology high-throughput drug discovery workflows.
  Time-resolved analysis by cryo-electron microscopy of regulators of ubiquitin signalling
  Dr R Enchev
Application Deadline: 17 March 2020

Funding Type

PhD Type

This 4-year PhD studentship is offered in Dr Rado Enchev’s Group based at the Francis Crick Institute (the Crick).
  A bioinformatics approach to understanding protein solubility tags
  Dr J Warwicker, Dr R Curtis
Applications accepted all year round

Funding Type

PhD Type

The crowded environment of a cell cytoplasm reveals that proteins and other biological molecules co-exist at high macromolecular concentrations.
  Exploiting druggability host spots in protein phosphatase targets
  Dr L Tabernero, Prof D Procter, Dr S Butterworth
Applications accepted all year round

Funding Type

PhD Type

In the past years the use of virtual screening or computer-based screening of compound libraries against selected targets has expanded exponentially the boundaries of drug discovery.
  Understanding Movement and Mechanism in Molecuar Machines (MACMILLANF2U20SF)
  Dr F MacMillan
Application Deadline: 31 May 2020

Funding Type

PhD Type

We study the architecture and functional dynamics of membrane proteins, especially many medically relevant membrane transport systems.
  Unravelling the mysteries of retinoid signalling
  Dr E Pohl, Prof J Endicott
Application Deadline: 6 March 2020

Funding Type

PhD Type

Retinoids, such as all-trans-retinoic acid (ATRA), are a class of endogenous molecules derived from Vitamin A. These compounds control a wide range of cellular processes in chordates, including differentiation, proliferation and apoptosis, by binding one or more of related transcriptional receptors in the cell nucleus.
  Developing H/D-exchange mass spectrometry for native membrane protein structural biology
  Dr E Reading
Application Deadline: 12 April 2020

Funding Type

PhD Type

Supervisors. Dr. Eamonn Reading (Primary supervisor – KCL), Mr. Malcolm Anderson (Industrial supervisor - Waters Corporation), Prof.
  Dynamic Structural Biology Studentship (stipend £2,000 above the standard UKRI rate)
  Prof E Raven, Dr A Orville, Prof P Moody
Application Deadline: 15 March 2020

Funding Type

PhD Type

Applications are invited for a studentship in dynamic structural biology starting in October 2020 to be jointly supervised by Dr Allen M.
  Identification of the Trypanosoma brucei transferrin receptor-recognition site of transferrin (SteverdingDU19SF)
  Dr D Steverding
Application Deadline: 31 May 2020

Funding Type

PhD Type

The transferrin receptor of the protozoan parasite Trypanosoma brucei (TbTfR) is a heterodimeric protein complex encoded by two expression site associated genes, ESAG6 and ESAG7, which shows no homology to the homodimeric human transferrin receptor (hTfR).
  Synthetic Virology: Development of gene delivery vectors/synthetic vaccines
  Research Group: Astbury Centre for Structural Molecular Biology
  Prof P G Stockley
Applications accepted all year round

Funding Type

PhD Type

There is worldwide interest in exploiting our modern understanding of genomics to target gene expression therapeutically via a variety of mechanisms, such as transgene insertion and CRISPR-Cas gene editing.
  Direct characterisation of TRPC channel dynamics triggered by drug-like modulators using high-speed atomic force microscopy
  Research Group: Molecular and Nanoscale Phsyics
  Dr G Heath
Applications accepted all year round

Funding Type

PhD Type

The rapid expansion in the structural understanding of membrane proteins through recent progress in electron microscopy and X-ray crystallography is leading to an ever greater need for techniques which provide high temporal resolution dynamics.
  Evolutionary insights for engineering improved globin oxygen carriers
  Dr M Berenbrink, Dr J Madine
Applications accepted all year round

Funding Type

PhD Type

Around 2 million red blood cell units at a cost of 120.00 GBP per unit are transfused annually in England alone (http://www.nhsbt.nhs.uk/what-we-do/blood-transfusion/).
  Molecular basis of cellular organisation
  Dr M Dodding
Applications accepted all year round

Funding Type

PhD Type

Research in our lab aims to understand the molecular mechanisms and signaling pathways that control the distribution and dynamics of subcellular components, focusing on structure, function, molecular mechanism and regulation of the key biomolecular machines regulate cellular organization including cytoskeletal motor proteins.
  The bacterial protein translocation machinery: a target for new strategies against antimicrobial resistance
  Prof I Collinson
Applications accepted all year round

Funding Type

PhD Type

Bacterial resistance to antibiotics is a major problem affecting millions of people across the world. This severely affects treatment of bacterial infections as strains are emerging that are totally resistant to all clinically used antibiotics.
  Structural biology of the intrinsically disordered protein SH2B1
  Prof M P Williamson
Applications accepted all year round

Funding Type

PhD Type

Signalling between the outside of the cell and the inside uses a complicated network of interacting systems. One common signalling mechanism uses receptor tyrosine kinases.
  Ligand-induced selective signalling of peptide GPCRs and their potential role in the regulation of mRNA methylation
  Prof Z Lu, Dr J Meng, Dr R Rong
Applications accepted all year round

Funding Type

PhD Type

G protein-coupled receptors (GPCRs) modulate the majority of physiological and pathological processes and constitute the largest family of cell surface receptors and drug targets.
  Novel microbial source tracking markers for identification of fecal contaminations in inflow rivers of Taihu Lake
  Dr S Raju, Prof A J McCarthy
Applications accepted all year round

Funding Type

PhD Type

The urban water system in China faces various challenges. Fecal pollution is one of the major concerns to watersheds. Taihu Lake serves as important drinking water source for many nearby cities in addition to many other roles including aquaculture, transportation and tourism.
  Developing a clinical tool to quantitatively assess and monitor upper limb and shoulder function in clinical and home settings
  Dr A Shaheen
Applications accepted all year round

Funding Type

PhD Type

Upper limb and shoulder disorders are poorly defined, diagnosed and rehabilitated. Current management of these disorders is focussed on the prescription of physiotherapeutic treatments, yet the efficacy of such treatments is not well established and the prognosis of patients with shoulder disorders is very poor.
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