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Structural Biology (structural biology) PhD Projects, Programs & Scholarships

We have 69 Structural Biology (structural biology) PhD Projects, Programs & Scholarships

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  Human chromosome segregation principles: Regulation of Astrin-PP1 interaction
  Prof VM Draviam, Prof RW Pickersgill, Dr JM Martin
Application Deadline: 26 April 2020

Funding Type

PhD Type

The School of Biological and Chemical Sciences at Queen Mary is one of the UK’s elite research centres, according to the 2014 Research Excellence Framework (REF).
  Understanding the mechanism of RNA recognition by La-related proteins
  Prof MR Conte
Applications accepted all year round

Funding Type

PhD Type

A PhD studentship is available to work in the laboratory of Prof. Sasi (Maria R) Conte (https://www.kcl.ac.uk/people/sasi-conte), in the Randall Centre for Cell and Molecular Biophysics, King’s College London (https://www.kcl.ac.uk/lsm/research/divisions/randall).
  Enzyme mechanism through advanced techniques
  Dr P C E Moody
Application Deadline: 3 May 2020

Funding Type

PhD Type

This studentship is for up to 4 years and supported by a Royal Society Wolfson Fellowship. “Traditional” protein X-ray crystallography has contributed enormously to our understanding of enzyme mechanisms.
  EPSRC Centre for Doctoral Training in Molecular Sciences for Medicine - 4 year PhD Studentships

Funding Type

PhD Type

 . The CDT in Molecular Sciences for Medicine (MoSMed) is a joint venture between Newcastle and Durham Universities. It will train the next generation of researchers at the interface of molecular and medical sciences, business skills, innovation and entrepreneurship.
  EPSRC Centre for Doctoral Training in Molecular Sciences for Medicine - 4 year PhD Studentships

Funding Type

PhD Type

 . The CDT in Molecular Sciences for Medicine (MoSMed) is a joint venture between Newcastle and Durham Universities. It will train the next generation of researchers at the interface of molecular and medical sciences, business skills, innovation and entrepreneurship.
  Ion channel clustering in neuronal membranes
  Dr S M Prince, Prof R Ford
Applications accepted all year round

Funding Type

PhD Type

The aim of the study is to investigate the organization of ion channels in the membranes of excitable cells by scaffold proteins, and to discover how the properties of the channels are modified by these interactions.
  The mechanism of gating and transport of pentameric Magnesium ion channels
  Dr S M Prince, Prof R Ford
Applications accepted all year round

Funding Type

PhD Type

Magnesium ions are a co-factor in many important biological processes particularly because of the requirement for Mg2+ in the hydrolysis of Adenosine tri-phosphate, the ubiquitous cellular energy source.
  Development of Novel Crystallization Methods for Integral Membrane Proteins
  Dr G Patchornik
Applications accepted all year round

Funding Type

PhD Type

Our research is focused on one of the major barriers in Structural biology. growing high quality three dimensional (3D) crystals of integral membrane proteins for structural analysis.
  PhD positions at the International Max Planck Research School in Chemical and Molecular Biology

Funding Type

PhD Type

Dortmund, Germany. Application Deadline. April 13th 2020. The International Max Planck Research School in Chemical and Molecular Biology (IMPRS-CMB) is looking for talented and motivated PhD candidates of all nationalities to carry out novel projects in the following research areas.
  Bioengineering of bacterial CO2-concentrating system for improved photosynthesis
  Prof LN Liu, Dr D Canniffe
Applications accepted all year round

Funding Type

PhD Type

The single-cell photosynthetic bacteria, cyanobacteria, account for over 25% of global carbon fixation, thanks for their powerful CO2-concentrating machinery.
  Control and inhibition of virus replication
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr A.K Tuplin
Applications accepted all year round

Funding Type

PhD Type


The Tuplin laboratory utilises a range of cutting-edge approaches to investigate how arboviruses - specificaly Chikungunya, Dengue and Zika viruses - control replication and translation of their genomes through interactions between RNA structures, host cell proteins and non-coding RNA, and the potential of such RNA elements/interactions as novel therapeutic targets.
  Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas
  Research Group: School of Molecular and Cellular Biology
  Dr J Boyes
Application Deadline: 1 April 2020

Funding Type

PhD Type

V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas.
  Structural and functional studies of outer membrane assembly in Gram-negative bacteria and mitochondria - DongMED_Oct2020
  Prof C Dong, Dr P Crichton
Application Deadline: 17 April 2020

Funding Type

PhD Type

The outer membrane plays essential roles in Gram-negative bacteria and mitochondria. Dysfunction of outer membrane proteins occur in several human diseases, such as diabetes, Parkinson and other neurodegenerative disease.
  Fostering development of ‘smart’, responsive therapeutics against cancer-related microRNAs.
  Dr E Bichenkova, Prof D Clarke, Dr H Aojula
Applications accepted all year round

Funding Type

PhD Type

Short functional non-coding microRNAs are implicated in many types of cancer, and thus can be used as biological targets for development of more selective and powerful anticancer therapies.
  Mitochondrial protein folding and diseases
  Prof L-Y Lian, Dr D Criddle
Applications accepted all year round

Funding Type

PhD Type

Many diseases, including cancer and neurological disease, stem from mitochondrial dysfunctions often triggered by sudden elevation of agents such as calcium and reactive oxygen species.
  Development of chemical biology tools to study mammalian O-mannosylation pathways
  Dr L Willems, Prof G Davies
Applications accepted all year round

Funding Type

PhD Type

The field of chemical biology aims to design and synthesize chemical tools (such as inhibitors, substrate mimics, or enzyme probes) to answer fundamental questions in biology.
  PhD position - Structural basis of melanogenesis enzymes
  Dr M Soler-Lopez
Applications accepted all year round

Funding Type

PhD Type

Ref. InnovaXN_17_ESRF. Categorisation. Places of work. - Grenoble, Rhône-Alpes, France. Contract type. Contract, start on 2020-09-07.
  Molecular mechanisms of herpesviral infection
  Dr A Golovanov
Applications accepted all year round

Funding Type

PhD Type

Herpes viruses are known to cause a wide range of human diseases, ranging from simple cold sores to cancer, Kaposi Sarcoma. Kaposi Sarcoma, for example, is a type of cancer which affects immunocompromised patients and is endemic in Africa, where it is linked with the spread of HIV infection and AIDS.
  Exploiting druggability host spots in protein phosphatase targets
  Dr L Tabernero, Prof D Procter, Dr S Butterworth
Applications accepted all year round

Funding Type

PhD Type

In the past years the use of virtual screening or computer-based screening of compound libraries against selected targets has expanded exponentially the boundaries of drug discovery.
  PhD Student - Functional Analysis of UHRF1 (f/m/d)
  Dr T Bartke
Applications accepted all year round

Funding Type

PhD Type

As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus, allergies and lung diseases.
  IMPRS "From Molecules To Organisms”

Funding Type

PhD Type

Our PhD program in the life sciences places special emphasis on interdisciplinary interactions. We want to train the next generation of scientists to study complex biological processes that cannot be adequately understood within the limits of a single discipline.
  The chemistry and biophysics of phosphoryl transfer enzymes
  Prof J Waltho, Dr A Almond
Applications accepted all year round

Funding Type

PhD Type

One of the most remarkable features of the chemistry of living organisms is the evolutionary utilisation of phosphate esters to provide biopolymers that encode genetic information, deliver temporal protein regulation, generate and distribute free energy throughout the cell, and to provide a ubiquitous handle for metabolic intermediates.
  The role of Efflux in Antibiotic Resistance of Clinically Relevant Pathogens
  Dr J Blair
Applications accepted all year round

Funding Type

PhD Type

Antibiotics underpin all of modern medicine; they are used to treat bacterial infections, and to prevent infections after surgery and in patients with a suppressed immune system such as those undergoing cancer chemotherapy or organ transplantation.
  IMPRS "From Molecules To Organisms”

Funding Type

PhD Type

Our PhD program in the life sciences places special emphasis on interdisciplinary interactions. We want to train the next generation of scientists to study complex biological processes that cannot be adequately understood within the limits of a single discipline.
  The chemical glycobiology of carbohydrate metabolism
  Prof R Field, Prof S Flitsch
Applications accepted all year round

Funding Type

PhD Type

Carbohydrates are widespread in nature and fulfil many important biological functions. However, the biology of carbohydrates is much less well explored than that of nucleic acids and proteins.
  Structure/function studies of component proteins of anti-feeding prophage (Afp), a bacteriophage tail-like particle using high-resolution cryo-EM and x-ray crystallography
  Prof A Mitra
Applications accepted all year round

Funding Type

PhD Type

We are seeking a highly motivated candidate to carry out structure/function studies of component proteins of anti-feeding prophage (Afp), a bacteriophage tail-like particle using high-resolution cryo-EM and x-ray crystallography.
  Regulating biosynthesis of the pigments of life
  Dr A Hitchcock, Dr P Jackson, Prof C N Hunter
Application Deadline: 31 March 2020

Funding Type

PhD Type

Tetrapyrroles are often referred to as the pigments of life as they are required for a number of vital cellular processes, including respiration (haems), photosynthesis (chlorophylls), amino acid biosynthesis (vitamin B12), sulphur and nitrogen assimilation (sirohaem) and methanogenesis (cofactor F430).
  Targeting intrinsic mechanisms of antibiotic resistance in bacterial pathogens
  Prof P Roach
Application Deadline: 15 May 2020

Funding Type

PhD Type

Supervisor. Prof. Peter Roach. Project description. Antimicrobial Resistance (AMR) is one of the most serious health threats globally and it is predicted that AMR bacteria will kill >10 million people by 2050.
  MRC DTP iCASE PhD Project: Developing novel biophysical and cellular assays to study small-molecule mediated protein ubiquitination and degradation
  Prof A Ciulli, Prof R Hay
Application Deadline: 31 March 2020

Funding Type

PhD Type

Bifunctional degrader molecules also known as Proteolysis Targeting Chimeras (PROTACs) and the mechanistically related monovalent degraders (for example auxin, lenalidomide and indisulam) work by co-opting an E3 ubiquitin ligase to act upon a neo-substrate protein.
  Four Year PhDs in Cancer, Immunology and Biomedicine

Funding Type

PhD Type

The Faculty of Medicine at the University of Southampton has a strong reputation in research, enterprise and education, with an emphasis on translating new discoveries from basic science into clinical innovation.
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