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We have 106 Structural Biology PhD Projects, Programmes & Scholarships
Structural Biology PhD Projects, Programmes & Scholarships
We have 106 Structural Biology PhD Projects, Programmes & Scholarships
MSc by Research: Feel the tension – how does S-acylation of OSCA ion channels regulate responses to environmental change in plants?
Plants, being sessile organisms, must sense and respond to environmental change, such as temperature or drought, without being able to move. Read more
MSc by Research: ADP-ribosylation in dementia and motor neuron disease
ADP-ribosylation is a fundamental posttranslational modification where ADP-ribose is linked on to target proteins by ADP-ribose transferases and removed by the ADP-ribose hydrolases. Read more
MSc by Research: Deciphering the ubiquitin codes that regulate protein degradation
Ubiquitin signalling, which involves the posttranslational modification (PTM) of proteins with ubiquitin, regulates almost every aspect of eukaryotic biology. Read more
MSc by Research: How are SUMO substrates selected for modification ?
SUMO has diverse roles in cellular physiology that in most cases are mediated by its ability to interact non-covalently with hydrophobic patches of low sequence complexity known as SUMO Interaction Motifs (SIMs). Read more
MSc by Research: Regulation and mechanics in polarized trafficking
Membranes and their protein organization are a frontier in our understanding of cell biology. We focus on polarized trafficking as a model to uncover fundamental mechanisms in the organization of structures at membranes. Read more
MSc by Research: Glueing proteins together with small molecules
Recent advances from the Ciulli Lab and others have contributed to the establishment of a game-changing new modality of chemical intervention into biological system – one that moves beyond the state-of-the-art. Read more
Structural and functional analysis of the protein complexes which regulate cell fate decisions to identify novel cancer therapies
Whether a cell dies or not has profound consequences on health and disease. In healthy tissue, cells that acquire high levels of genetic damage are safely removed via a process of programmed cell death. Read more
Epigenetics of early human development: From molecular mechanisms to regenerative medicine
The 46th chromosome in XX female mammals, the second X, has to be switched off. That way females equalize gene dosage of X-linked genes with XY males. Read more
Join Our Quest to Unravel the Secrets of Eukaryotic Genomes!
We're on the lookout for passionate PhD students who are eager to delve deep into the mysteries of our DNA. Our quest? To understand the subtle changes that determine how our genes function, both in sickness and in health. Read more
mRNA epigenetics: Charaterization of a novel layer of gene regulation for essential brain functions
For over 40 years we know about modified nucleotides in mRNA, but the functions for these essential modifications are largely elusive. Read more
Chemical modification of proteins via metal-mediated processes
Chemically modified proteins can be used to understand, treat, and diagnose disease. However, relatively few chemical reactions can be used to modify proteins, severely limiting the diversity and applications of new technologies. Read more
Analysis of pathogen determinants recognized by the hypervariable immune receptor Dscam
Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response. Read more
Structural investigation of oncogenic splicing factors
More than 90% of human genes can and do express multiple proteins. This is achieved by a process called alternative RNA splicing, which is an essential step in gene expression in mammals. Read more
Obtaining an integrated understanding of oncogenic RAS signalling
The RAS family of small GTPases act as signalling hubs regulating cell proliferation and differentiation. The physiological importance of RAS signalling is evident as about 25% of all human cancers harbour mutations in ras genes, where kras is most frequently mutated (about 18%) (COSMIC, v94). Read more
Design and engineering of peptides and proteins to create artificial metalloenzymes
The Rhys lab is an exciting new lab looking to recruit new students to design and engineer peptides and proteins for new applications (rhyslab.com). Read more