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Structural Biology PhD Projects, Programs & Scholarships

We have 119 Structural Biology PhD Projects, Programs & Scholarships

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We have 119 Structural Biology PhD Projects, Programs & Scholarships

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Deciphering the in vivo RNA structure code in regulating protein translation in plants (DING_J22DTP2)

Codon optimisation is a common method in synthetic biology to achieve high levels of protein expression. It relies on the creation of so-called “silent” or synonymous mutations within a coding sequence, such that the DNA/RNA sequence is altered but the resulting amino acid sequence remains unchanged. Read more

Location location location - how genome position affects gene expression (WEBBER_Q22DTP)

Bacterial genomes have evolved over billions of year to allow efficient expression of the right genes at the right times. It has become clear that the same gene, placed in different locations around a bacterial chromosome can display very different levels of expression. Read more

*Eastbio*: Serum albumin glycation and its impact on Zn2+-dependent haemostasis and insulin dynamics

Zinc is an essential micronutrient in mammals, vital to virtually all physiological pathways and processes. High nanomolar concentrations of free zinc ions (Zn2+) are cytotoxic; therefore, extracellular zinc is usually well-buffered. Read more

EASTBIO CASE Molecular engineering of the ubiquitin-proteasome system: A new approach to pathogen resistance in plants

  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
Barley (Hordeum vulgare) is the fourth most important crop worldwide and second in the UK. Diseases, including those caused by the brown rust pathogen, Puccinia hordei, cause barley yield losses of up to 40%. Read more

EASTBIO The role of host membrane protein interactions in herpesvirus nuclear egress and SARS-CoV-2 double membrane vesicle formation

  Research Group: Institute of Cell Biology
    Viruses have many critical interactions with host cell membranes that mostly take advantage of host cell proteins. The Schirmer and Graham labs have 2 lines of investigation involving virus interactions with host cell membrane proteins that could be individually or jointly carried further in this PhD project. . Read more

EASTBIO Bone biomineralisation

This project will investigate the fundamental mechanisms which regulate bone mineralisation through extracellular vesicles. A deeper understanding of this process will expose new therapeutic targets for the treatment of bone disorders. Read more

EASTBIO Expanding the chemistry of non-heme enzymes

Chemical synthesis is widely viewed as being unsustainable. Whilst this is an oversimplification, in many cases chemical production still relies on petrochemicals, rare metals and high energy consumption to make the products we need for modern life. Read more

EASTBIO New chemical tools to understand and exploit tubulin diversity

Microtubules are long polymers important for cell division, intracellular transport and polarity. Many isotypes of microtubules co-exist in human cells and levels of expression vary with the cell type. Read more

EASTBIO Molecular and regulatory insights into getting out of mitosis

  Research Group: Institute of Cell Biology
The fidelity of chromosome segregation is essential to ensure genome stability. Failure to exit mitosis and complete cell division results in tetraploidy and extra centrosomes which is a path to tumour development and drug resistance. Read more

EASTBIO An integrated approach to deciphering the role of proline in intrinsically disordered protein regions

Proteins often have a well-defined structure that is key to it performing their function. Intrinsically disordered regions (IDRs) have no defined 3D structure and are found in many proteins, yet their purpose is poorly understood. Read more

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