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We have 133 Structural Biology PhD Projects, Programmes & Scholarships for Self-funded Students
Structural Biology PhD Projects, Programmes & Scholarships for Self-funded Students
We have 133 Structural Biology PhD Projects, Programmes & Scholarships for Self-funded Students
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White Rose BBSRC DTP studentship: CryoEM and structural mapping of gene-regulatory non-coding RNAs
The project background. RNA molecules can fold into intricate, highly dynamic, secondary and tertiary structures that are essential for their biological function. Read more
A Novel K+ Channel Target (KCNK13/THIK1) for Neurodegenerative Disorders: Understanding its mechanism of inhibition by small molecule drugs and biological therapeutics
Commercial partner: . Cerevance. The student will be involved in an exciting multidisciplinary project aimed at determining the structural and molecular mechanisms of a range of novel inhibitors of the THIK1 K2P K+ channel. Read more
Chromatin remodelling complexes in human brain development
Chromatin regulators are a group of proteins that control the way the rest of the genome is opened up and “read” by the cellular machinery, with fundamental roles in development and disease. Read more
PHD POSITION IN THE FIELD OF IN VITRO SINGLE-MOLECULE BIOPHYSICS TO INVESTIGATE THE REGULATION OF SARS-COV-2 REPLICATION AND TRANSCRIPTION
The Dulin lab offers one fully funded PhD position for 4 years to start as soon as possible in the field of in vitro single-molecule biophysics to investigate the regulation of SARS-CoV-2 replication and transcription. Read more
Targeting Ras palmitoylation for the treatment of cancer
Lay summary. Proteins can be thought of as molecular machines that carry out work within cells. Protein activity can be regulated through the reversible attachment of certain chemical groups to specific amino acids within proteins. Read more
Structural and Mechanistic Chemical Biology of Degraders Mode of Actions
Pioneering discoveries from the Ciulli Laboratory have contributed to the establishment of a new modality of chemical intervention into biological systems. Read more
Regulation and mechanics in polarity
Membranes and their protein organization are a frontier in our understanding of cell biology. We focus on polarized trafficking as a model to uncover fundamental mechanisms in the organization of structures at membranes. Read more
MSc by Research: How are SUMO substrates selected for modification ?
SUMO has diverse roles in cellular physiology that in most cases are mediated by its ability to interact non-covalently with hydrophobic patches of low sequence complexity known as SUMO Interaction Motifs (SIMs). Read more
MSc by Research: Feel the tension – how does S-acylation of OSCA ion channels regulate responses to environmental change in plants?
Plants, being sessile organisms, must sense and respond to environmental change, such as temperature or drought, without being able to move. Read more
MSc by Research: Deciphering the ubiquitin codes that regulate protein degradation
Ubiquitin signalling, which involves the posttranslational modification (PTM) of proteins with ubiquitin, regulates almost every aspect of eukaryotic biology. Read more
MSc by Research: Bringing proteins together with functional small molecules
Recent advances from the Ciulli Lab and others have contributed to the establishment of a game-changing new modality of chemical intervention into biological system – one that moves beyond the state-of-the-art. Read more
MSc by Research: ADP-ribosylation in dementia and motor neuron disease
ADP-ribosylation is a fundamental posttranslational modification where ADP-ribose is linked on to target proteins by ADP-ribose transferases and removed by the ADP-ribose hydrolases. Read more
Modelling blood motion in deformable vessels
This project aims to introduce a novel approach in studying blood flow in deformable vessels by simultaneously considering both the fluid (blood) and the structure (vessel) through analytical and numerical approaches. Read more
Bifunctional small molecules beyond PROTACs: Proximity-inducing new downstream chemistries to rewire cell signalling
Proteolysis targeting chimeras (PROTACs) are a popular class of bifunctional molecules that simultaneously engage a target protein on one end and an E3 ubiquitin ligase on the other end, forming a ternary complex that facilitates the rapid ubiquitylation and subsequent degradation of the target protein. Read more
PhD position (f/m/d) in Single Molecule Biophysics
The research group of Dr. Katja Zieske invites applications for a. PhD position (f/m/d) in Single Molecule Biophysics. for the project. Read more