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Structural Biology (genomic) PhD Projects, Programmes & Scholarships

We have 5 Structural Biology (genomic) PhD Projects, Programmes & Scholarships

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We have 5 Structural Biology (genomic) PhD Projects, Programmes & Scholarships

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3D genome folding and its role in DNA-based processes

The organization of genomic DNA into chromatin fibres and nucleosomes and their regulation by histone modifications is well understood, as is the relevance of these mechanisms for gene regulation. Read more

Does membrane repair fail to alert the immune system to disease?

The cGAMP-synthase cGAS recognises microbial or self-DNA to activate STING and induce the release of pro-inflammatory molecules. But cytoplasmic DNA is also particularly abundant in cancer cells, under the form of genomic structures called ‘micronuclei’. Read more

Evolution of vertebrate blood vessels

The blood vessels are the core elements of the circulatory system of animals, and their malfunction is related to most human diseases including cancer and heart attacks. Read more

Role of APC/C subunit post-translational modifications on the function of the APC/C in mitosis

The APC/C is a large macromolecular E3 ubiquitin ligase, that, through targeting protein substrates for polyubiquitylation and 26S proteasome-mediated degradation coordinates the progression of cells through mitosis (1, 2). Read more

Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas

  Research Group: School of Molecular and Cellular Biology
V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas. Read more
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