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The University of Manchester Structural Biology PhD Projects, Programs & Scholarships

We have 18 The University of Manchester Structural Biology PhD Projects, Programs & Scholarships

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The University of Manchester

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We have 18 The University of Manchester Structural Biology PhD Projects, Programs & Scholarships

Ion channel clustering in neuronal membranes

The aim of the study is to investigate the organization of ion channels in the membranes of excitable cells by scaffold proteins, and to discover how the properties of the channels are modified by these interactions. Read more

Evolution of antimicrobial resistance

The increasing prevalence of anti-microbial resistance (AMR) is one of the key health challenges of the 21st centuryThe emergence of AMR is inherently an evolutionary problem. Read more

The chemistry and biophysics of phosphoryl transfer enzymes

One of the most remarkable features of the chemistry of living organisms is the evolutionary utilisation of phosphate esters to provide biopolymers that encode genetic information, deliver temporal protein regulation, generate and distribute free energy throughout the cell, and to provide a ubiquitous handle for metabolic intermediates. Read more

A step change in the modelling of enzymatic catalysis

A deep understanding of enzymatic processes requires an atomic-level description, which is often beyond experimental techniques but achievable through synergy with computational chemistry. Read more

Development of Convolutional Neural Networks and Associated Error Estimation Techniques for Vertebral Segmentation in Axial Computed Tomography Image Slices

Osteoporosis is a common skeletal disorder that increases the risk of fractures and causes significant morbidity and mortality. Vertebral fractures (VFs) are often an early manifestation of osteoporosis but are significantly under-diagnosed in clinical practice. Read more

Understanding the interaction and functional mechanism of mitochondrial MIA pathway

Mitochondria are vitally important organelles of living cells, which generate the primary energy for all biological activities. Mitochondrial dysfunction leads to life threatening diseases, such as cancer, diabetes, stroke, and various neurodegenerative diseases (e.g. Read more

Evolution of vertebrate blood vessels

The blood vessels are the core elements of the circulatory system of animals, and their malfunction is related to most human diseases including cancer and heart attacks. Read more

Investigation of aortic remodelling in obesity and role of mitochondrial dysfunction

Obesity is a global healthcare and economic burden with currently more than 650 million adults classified as obese (WHO, 2017). Obesity is a common precursor to type 2 diabetes (T2DM), and both are risk factors for developing cardiovascular disease. Read more

Insights into eye disease: understanding the molecular basis of age-related macular degeneration

Dysregulation of innate immunity has been implicated as playing a key role in the development of age-related macular degeneration (AMD) – a major form of blindness in the industrialised world (see [1-5]). Read more

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