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We have 205 Structural Biology PhD Projects, Programmes & Scholarships for UK Students
Structural Biology PhD Projects, Programmes & Scholarships for UK Students
We have 205 Structural Biology PhD Projects, Programmes & Scholarships for UK Students
Decoding the mechanism and function of UFMylation in ER Quality Control
Approximately one third of the human proteome depends on the endoplasmic reticulum (ER) for its biosynthesis. Read more
How do Dysregulated Signalling Pathways cause Intellectual Disability?
The goal of our lab is to understand how signal transduction is disrupted to cause intellectual disability, which is a major healthcare challenge world-wide. Read more
Understanding HDAC1 recruitment into diverse multi-protein complexes
The DNA of all eukaryotic organisms is packaged with histone proteins to form chromatin. Chromatin forms a physical barrier to all processes that need access to DNA (e.g., transcription). Read more
Targeting the Mla Pathway: A Strategy to Combat Multidrug-Resistant Gram-Negative Bacteria
The emergence of antibiotic-resistant bacteria poses a serious and growing global threat, emphasizing the urgent need for new targets and strategies to combat infections. Read more
Developing a Surface-tethered Double Membrane Model to Study Bacterial Envelope Biogenesis
Project Overview. The rise of antimicrobial resistance, particularly among Gram-negative bacteria, is a pressing global health concern. Read more
Redefining the molecular mechanism of DNA double-strand break repair in humans
DNA double-strand breaks (DSBs) describe a break across both strands of DNA. This type of DNA damage can be catastrophic for cell survival as if not repaired correctly can lead to deletions, translocation, cell death and cancer. Read more
Investigating AsmA-like Proteins as Key Mediators of Lipid Transport in Gram-negative Bacteria
Project Overview. Antibiotic-resistant bacteria pose a significant and escalating global health challenge, particularly due to the rise of multidrug-resistant Gram-negative bacteria. Read more
Deciphering the Role of MCE-domain containing Proteins in Outer Membrane Lipid Transport in Gram-negative Bacteria
Project Overview. The growing threat of antibiotic-resistant bacteria highlights an urgent need for novel therapeutic strategies. Read more
Mechanism of phage infection in the C. difficile pathogen- towards effective phage therapy
Increasing resistance to antibiotics is one of the greatest challenges facing humanity today. Clostridioides difficile is the primary cause of antibiotic-associated infections in UK hospitals and antibiotic-induced disruption of the gut microbiota is a prerequisite for infection. Read more
Deciphering the mechanism of Plasmodium apicoplast lagging strand replication
We invite applications for a BBSRC funded Yorkshire Biociences Doctoral Training Program (DTP) studentship to study how organellar replication functions in Plasmodium, the pathogen responsible for causing malaria. . Read more
How does non-coding RNA structure regulate gene expression?
Background. Long non-coding RNAs (lncRNAs) play a vital role in human physiology through regulating gene expression, impacting fundamental cellular processes. Read more
Last chance to apply
Cryo-electron tomography of RNA virus replication
We are looking for a PhD student in Medical Science with an interest in molecular and structural virology. The position at the Department of Medical Biochemistry and Biophysics at Umeå University, Sweden, is temporary for four years to start during spring 2025 or as agreed. Read more
Structural studies of DNA double-strand break repair in plants
Our research aims to understand and manipulate plant DNA-repair pathways. This project elucidates the molecular mechanism of non-homologous end joining (NHEJ) for double-strand break (DSB) repair in Arabidopsis. Read more
Reading, writing and molecular switching in the DNA-damage response
The proposed project revolves around a fascinating and unique class of regulatory proteins that seem to function as molecular shape-shifters, able to adopt a number of distinct structural forms each tailored to functionally specific downstream signalling processes. Read more
Regulation of RNA:DNA hybrid metabolism for genome stability
Proper regulation of RNA:DNA hybrids such as misincorporated ribonucleotides and R-loops is important for genome stability and healthy development. Read more